Stem Cells Therapy for Multiple Sclerosis

2020 ◽  
pp. 99-115
Author(s):  
Nassim Abi Chahine ◽  
Paul Lu
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Stem Cells Therapy

Biochemical Evaluation to Mesenchymal Stem Cells Therapy of Renal Tubulointerstitial Injury

2011 ◽  
Vol 3 (10) ◽  
pp. 1-5
Author(s):  
Zahran F Zahran F ◽  
◽  
El-Ghareb M El-Ghareb M ◽  
Nashwa Barakat ◽  
El-Naggar I El-Naggar I
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tubulointerstitial Injury ◽  
Stem Cells Therapy ◽  
Biochemical Evaluation

scholarly journals Correction to: Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Neil H. Riordan ◽  
Isabela Morales ◽  
Giselle Fernández ◽  
Nicole Allen ◽  
Neal E. Fearnot ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Tissue

An amendment to this paper has been published and can be accessed via the original article.

The potential use of mesenchymal stem cells for the treatment of multiple sclerosis

Life Sciences ◽  
2019 ◽  
Vol 235 ◽  
pp. 116830 ◽  
Author(s):  
Sahar Rostami Mansoor ◽  
Ebrahim Zabihi ◽  
Maryam Ghasemi-Kasman
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Potential Use

scholarly journals DOP059 Combined anticytokine and local mesenchymal stem cells therapy promotes longer healing of simple fistulas in patients with Crohn’s disease

2018 ◽  
Vol 12 (supplement_1) ◽  
pp. S071-S072
Author(s):  
N Belyakov ◽  
O Knyazev ◽  
N Fadeeva ◽  
N Orlova ◽  
A Konoplyannikov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Stem Cells Therapy

Therapeutic Effects of Physical Exercise and the Mesenchymal Stem Cell Secretome by Modulating Neuroinflammatory Response in Multiple Sclerosis

2021 ◽  
Vol 16 ◽  
Author(s):  
Lina María González ◽  
Laura Natalia Ospina ◽  
Laura Elena Sperling ◽  
Orlando Chaparro ◽  
Jaison Daniel Cucarián
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Physical Exercise ◽  
Disease Progression ◽  
Neuronal Damage ◽  
Experimental Studies ◽  
Chronic Inflammatory Disease ◽  
Therapeutic Effects ◽  
Local Inflammatory Response ◽  
Neuroinflammatory Response

Multiple sclerosis (MS) is a neurodegenerative, demyelinating, and chronic inflammatory disease characterized by central nervous system (CNS) lesions that lead to high levels of disability and severe physical and cognitive disturbances. Conventional therapies are not enough to control the neuroinflammatory process in MS and are not able to inhibit ongoing damage to the CNS. Thus, the secretome of mesenchymal stem cells (MSC-S) has been postulated as a potential therapy that could mitigate symptoms and disease progression. We considered that its combination with physical exercise (EX) could induce superior effects and increase the MSC-S effectiveness in this condition. Recent studies have revealed that both EX and MSC-S share similar mechanisms of action that mitigate auto-reactive T cell infiltration, regulate the local inflammatory response, modulate the proinflammatory profile of glial cells, and reduce neuronal damage. Clinical and experimental studies have reported that these treatments in an isolated way also improve myelination, regeneration, promote the release of neurotrophic factors, and increase the recruitment of endogenous stem cells. Together, these effects reduce disease progression and improve patient functionality. Despite these results, the combination of these methods has not yet been studied in MS. In this review, we focus on molecular elements and cellular responses induced by these treatments in a separate way, showing their beneficial effects in the control of symptoms and disease progression in MS, as well as indicating their contribution in clinical fields. In addition, we propose the combined use of EX and MSC-S as a strategy to boost their reparative and immunomodulatory effects in this condition, combining their benefits on synaptogenesis, neurogenesis, remyelination, and neuroinflammatory response. The findings here reported are based on the scientific evidence and our professional experience that will bring significant progress to regenerative medicine to deal with this condition.

Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion of mesenchymal stem cells in multiple sclerosis patients

Cytokine ◽  
2021 ◽  
Vol 148 ◽  
pp. 155706
Author(s):  
Gholamhossein Hassanshahi ◽  
Mohammad Amin Roohi ◽  
Seyed-Alireza Esmaeili ◽  
Hossein Pourghadamyari ◽  
Reza Nosratabadi
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Chemokine Receptor ◽  
Multiple Sclerosis Patients
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