Potential of Curcumin Nanoparticles in Tuberculosis Management

2021 ◽  
pp. 225-249
Author(s):  
Bhabani Shankar Das ◽  
Ashirbad Sarangi ◽  
Debapriya Bhattacharya
2020 ◽  
Vol 10 (5) ◽  
pp. 577-590
Author(s):  
Jai B. Sharma ◽  
Shailendra Bhatt ◽  
Asmita Sharma ◽  
Manish Kumar

Background: The potential use of nanocarriers is being explored rapidly for the targeted delivery of anticancer agents. Curcumin is a natural polyphenolic compound obtained from rhizomes of turmeric, belongs to family Zingiberaceae. It possesses chemopreventive and chemotherapeutic activity with low toxicity in almost all types of cancer. The low solubility and bioavailability of curcumin make it unable to use for the clinical purpose. The necessity of an effective strategy to overcome the limitations of curcumin is responsible for the development of its nanocarriers. Objective: This study is aimed to review the role of curcumin nanocarriers for the treatment of cancer with special emphasis on cellular uptake and in vitro cytotoxicity studies. In addition to this, the effect of various ligand conjugated curcumin nanoparticles on different types of cancer was also studied. Methods: A systematic review was conducted by extensively surfing the PubMed, science direct and other portals to get the latest update on recent development in nanocarriers of curcumin. Results: The current data from recent studies showed that nanocarriers of curcumin resulted in the targeted delivery, higher efficacy, enhanced bioavailability and lower toxicity. The curcumin nanoparticles showed significant inhibitory effects on cancer cells as compared to free curcumin. Conclusion: It can be concluded that bioavailability of curcumin and its cytotoxic effect to cancer cells can be enhanced by the development of curcumin based nanocarriers and it was found to be a potential drug delivery technique for the treatment of cancer.


2021 ◽  
Author(s):  
Nagasai C. Adusumilli ◽  
Breanne Mordorski ◽  
Joshua Nosanchuk ◽  
Joel M. Friedman ◽  
Adam J. Friedman

2015 ◽  
Vol 94 ◽  
pp. 436-449 ◽  
Author(s):  
Shing Fung Chow ◽  
Ka Yee Wan ◽  
Kwok Kin Cheng ◽  
Ka Wai Wong ◽  
Changquan Calvin Sun ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4998
Author(s):  
Hitesh Chopra ◽  
Protity Shuvra Dey ◽  
Debashrita Das ◽  
Tanima Bhattacharya ◽  
Muddaser Shah ◽  
...  

Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in various treatments of various disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics and wound healing applications. Several techniques had been exploited as reported by researchers for increasing the therapeutic potential and its pharmacological activity. Here, the dictum is the new room for the development of physicochemical, as well as biological, studies for the efficacy in target specificity. Here, we discussed nanoformulation techniques, which lend support to upgrade the characters to the curcumin such as enhancing bioavailability, increasing solubility, modifying metabolisms, and target specificity, prolonged circulation, enhanced permeation. Our manuscript tried to seek the attention of the researcher by framing some solutions of some existing troubleshoots of this bioactive component for enhanced applications and making the formulations feasible at an industrial production scale. This manuscript focuses on recent inventions as well, which can further be implemented at the community level.


2021 ◽  
Vol 51 (2) ◽  
pp. 239-256
Author(s):  
AMANY F. ATIA ◽  
NOHA A. ABOKHALIL ◽  
DINA M. SWEED ◽  
INAS M. MOAZ ◽  
NOHA M. ABOU HUSSIEN

2016 ◽  
Vol 45 (1) ◽  
pp. 98-107 ◽  
Author(s):  
Mo’ath Ahmad Adahoun ◽  
Mohammed-Ali Hassan Al-Akhras ◽  
Mohamad Suhaimi Jaafar ◽  
Mohamed Bououdina

2020 ◽  
Vol 2 (8) ◽  
Author(s):  
Theresa F. Rambaran

AbstractPolyphenols are believed to possess numerous health benefits and can be grouped as phenolic acids, flavonoids or non-flavonoids. Research involving the synthesis of nanopolyphenols has attracted interest in the areas of functional food, nutraceutical and pharmaceutical development. This is in an effort to overcome current challenges which limit the application of polyphenols such as their rapid elimination, low water-solubility, instability at low pH, and their particle size. In the synthesis of nanopolyphenols, the type of nanocarrier used, the nanoencapsulation technique employed and the type of polymers that constitute the drug delivery system are crucial. For this review, all mentioned factors which can influence the therapeutic efficacy of nanopolyphenols were assessed. Their efficacy as anti-diabetic agents was also evaluated in 33 publications. Among these were phenolic acid (1), flavonoids (13), non-flavonoids (17) and polyphenol-rich extracts (2). The most researched polyphenols were quercetin and curcumin. Nanoparticles were the main nanocarrier and the size of the nanopolyphenols ranged from 15 to 333 nm with encapsulation efficiency and drug loading capacities of 56–97.7% and 4.2–53.2%, respectively. The quantity of nanomaterial administered orally ranged from 1 to 300 mg/kg/day with study durations of 1–70 days. Most studies compared the effect of the nanopolyphenol to its free-form and, in all but three cases, significantly greater effects of the former were reported. Assessment of the polyphenol to understand its properties and the subsequent synthesis of its nanoencapsulated form using suitable nanocarriers, polymers and encapsulation techniques can result in effective therapeutic agents for the treatment of diabetes.


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