Design Principles for Ionic Liquids in Drug Delivery Systems

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

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Fluorinated Ionic Liquids as Task-Specific Materials: An Overview of Current Research

10.5772/intechopen.96336 ◽

2021 ◽

Author(s):

Nicole S.M. Vieira ◽

Margarida L. Ferreira ◽

Paulo J. Castro ◽

João M.M. Araújo ◽

Ana B. Pereiro

Keyword(s):

Drug Delivery ◽

Thermal Stability ◽

Surface Tension ◽

Ionic Liquids ◽

Surface Activity ◽

Vapour Pressure ◽

Drug Delivery Systems ◽

Delivery Systems ◽

High Thermal Stability ◽

Gas Solubility

This chapter is focused on the massive potential and increasing interest on Fluorinated Ionic Liquids (FILs) as task-specific materials. FILs are a specific family of ionic liquids, with fluorine tags equal or longer than four carbon atoms, that share and improve the properties of both traditional ionic liquids and perfluoro surfactants. These compounds have unique properties such as three nanosegregated domains, a great surfactant power, chemical/biological inertness, easy recovery and recyclability, low surface tension, extreme surface activity, high gas solubility, negligible vapour pressure, null flammability, and high thermal stability. These properties allied to the countless possible combinations between cations and anions allow the design and development of FILs with remarkable properties to be used in specific applications. In this review, we highlight not only the unique thermophysical, surfactant and toxicological properties of these fluorinated compounds, but also their application as task-specific materials in many fields of interest, including biomedical applications, as artificial gas carries and drug delivery systems, as well as solvents for separations in engineering processes.

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Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Drug Discovery Today ◽

10.1016/j.drudis.2019.02.001 ◽

2019 ◽

Vol 24 (8) ◽

pp. 1446-1457 ◽

Cited By ~ 22

Author(s):

Astrid Subrizi ◽

Eva M. del Amo ◽

Viktor Korzhikov-Vlakh ◽

Tatiana Tennikova ◽

Marika Ruponen ◽

...

Keyword(s):

Drug Delivery ◽

Release Rate ◽

Material Properties ◽

Drug Delivery Systems ◽

Design Principles ◽

Delivery Systems ◽

Ocular Drug Delivery

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Current Advances of Transdermal Drug Delivery Systems Using Ionic Liquids

MEMBRANE ◽

10.5360/membrane.46.300 ◽

2021 ◽

Vol 46 (5) ◽

pp. 300-305

Author(s):

Yoshiro Tahara ◽

Masahiro Goto

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Transdermal Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Transdermal Drug Delivery Systems

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Advances Brought by Ionic Liquids in the Development of Polymer-Based Drug Delivery Systems

10.1007/978-981-16-4365-1_7 ◽

2021 ◽

pp. 113-135

Author(s):

Sónia N. Pedro ◽

Carmen S. R. Freire ◽

Armando J. D. Silvestre ◽

Mara G. Freire

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Drug Delivery Systems ◽

Delivery Systems

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Ionic liquids as a potential tool for drug delivery systems

MedChemComm ◽

10.1039/c6md00358c ◽

2016 ◽

Vol 7 (10) ◽

pp. 1881-1897 ◽

Cited By ~ 109

Author(s):

Noorul Adawiyah ◽

Muhammad Moniruzzaman ◽

Siti Hawatulaila ◽

Masahiro Goto

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Molecules ◽

Pharmaceutical Industries ◽

Low Solubility ◽

Potential Tool

The pharmaceutical industries face a series of challenges in the delivery of many newly developed drug molecules because of their low solubility, bioavailability, stability and polymorphic conversion.

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Ionic liquids as ingredients in topical drug delivery systems

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2012.10.035 ◽

2013 ◽

Vol 441 (1-2) ◽

pp. 620-627 ◽

Cited By ~ 94

Author(s):

Dorota Dobler ◽

Thomas Schmidts ◽

Ines Klingenhöfer ◽

Frank Runkel

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Topical Drug Delivery

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Ionic Liquids in Drug Delivery

Encyclopedia ◽

10.3390/encyclopedia1020027 ◽

2021 ◽

Vol 1 (2) ◽

pp. 324-339

Author(s):

Sónia N. Pedro ◽

Carmen S. R. Freire ◽

Armando J. D. Silvestre ◽

Mara G. Freire

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Drug Delivery Systems ◽

Organic Cation ◽

Delivery Systems ◽

Ionic Character ◽

Atmospheric Conditions ◽

Routes Of Administration ◽

Pharmaceutical Ingredients ◽

Novel Drug

Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.

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