Non-flavonoids Targeting Cancer Stem Cells: A Promising Therapeutic Avenue for Cancer Treatment

2021 ◽  
pp. 289-334
Author(s):  
Faizan Uddin ◽  
Mehboob Hoque
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment ◽  
Therapeutic Avenue

scholarly journals Graphene oxide selectively targets cancer stem cells, across multiple tumor types: Implications for non-toxic cancer treatment, via “differentiation-based nano-therapy”

Oncotarget ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 3553-3562 ◽  
Author(s):  
Marco Fiorillo ◽  
Andrea F. Verre ◽  
Maria Iliut ◽  
Maria Peiris-Pagés ◽  
Bela Ozsvari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Graphene Oxide ◽  
Cancer Stem Cells ◽  
Cancer Treatment ◽  
Multiple Tumor ◽  
Tumor Types

scholarly journals Cancer stem cells and therapeutic targets: an emerging field for cancer treatment

2012 ◽  
Vol 3 (2) ◽  
pp. 113-120 ◽  
Author(s):  
Arokia Priyanka Vaz ◽  
Moorthy P. Ponnusamy ◽  
Surinder K. Batra
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment ◽  
Therapeutic Targets

Role of miRNA and cancer stem cells in chemoresistance and pancreatic cancer treatment

2012 ◽  
Vol 9 (12) ◽  
pp. 1443-1447 ◽  
Author(s):  
Michael Danquah ◽  
Saurabh Singh ◽  
Stephen W Behrman ◽  
Ram I Mahato
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment

scholarly journals Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Jeffrey Koury ◽  
Li Zhong ◽  
Jijun Hao
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment ◽  
Signaling Pathways ◽  
Small Subset ◽  
Self Renewal ◽  
Multiple Tumor ◽  
Notch Pathways ◽  
Tumor Types ◽  
Heterogeneous Tumor

The Wnt, Hedgehog, and Notch pathways are inherent signaling pathways in normal embryogenesis, development, and hemostasis. However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. The CSCs are accountable for tumor initiation, growth, and recurrence. In this review, we focus on roles of Wnt, Hedgehog, and Notch pathways in CSCs’ stemness and functions and summarize therapeutic studies targeting these pathways to eliminate CSCs and improve overall cancer treatment outcomes.

scholarly journals Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Chen-Hsi Hsieh ◽  
K. S. Clifford Chao ◽  
Hui-Fen Liao ◽  
Yu-Jen Chen
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment ◽  
Treatment Resistance ◽  
Notch Signaling Pathway ◽  
Chemotherapeutic Agents ◽  
Water Soluble ◽  
Self Renewal ◽  
Active Efflux ◽  
Effective Strategies

Cancer stem cells (CSCs) existing in human cancers have been demonstrated to be a major cause of cancer treatment resistance, invasion, metastasis, and relapse. Self-renewal pathways, Wnt/β-catenin, Sonic hedgehog (Shh), and the Notch signaling pathway play critical roles in developing CSCs and lead to angiogenesis, migration, invasion, and metastasis. Multidrug resistance (MDR) is an unfavorable factor causing the failure of treatments against cancer cells. The most important and thoroughly studied mechanism involved in MDR is the active efflux of chemotherapeutic agents through membrane drug transporters. There is growing evidence that Norcantharidin (NCTD), a water-soluble synthetic small molecule derivative of naturally occurring cantharidin from the medicinal insect blister beetle (Mylabris phalerataPallas), is capable of chemoprevention and tumor inhibition. We summarize investigations into the modulation of self-renewal pathways and MDR in CSCs by NCTD. This review may aid in further investigation of using NCTD to develop more effective strategies for cancer treatment to reduce resistance and recurrence.

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