3D Printing and Bioprinting of Biomaterials and Bioceramic Scaffolds: Clinical Outcomes and Implications in Bone Tissue Engineering and Maxillofacial Reconstructive Surgery

2022 ◽  
pp. 15-33
Author(s):  
Muhja Salah ◽  
Farhad B. Naini ◽  
Lobat Tayebi
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Clinical Outcomes ◽  
Reconstructive Surgery

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

scholarly journals 3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1962 ◽  
Author(s):  
Abdullah M. Cakmak ◽  
Semra Unal ◽  
Ali Sahin ◽  
Faik N. Oktar ◽  
Mustafa Sengor ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bacterial Cellulose ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Bone Tissue Regeneration ◽  
Engineering Applications ◽  
Bioactive Materials ◽  
Degradation Rates

Three-dimensional (3D) printing application is a promising method for bone tissue engineering. For enhanced bone tissue regeneration, it is essential to have printable composite materials with appealing properties such as construct porous, mechanical strength, thermal properties, controlled degradation rates, and the presence of bioactive materials. In this study, polycaprolactone (PCL), gelatin (GEL), bacterial cellulose (BC), and different hydroxyapatite (HA) concentrations were used to fabricate a novel PCL/GEL/BC/HA composite scaffold using 3D printing method for bone tissue engineering applications. Pore structure, mechanical, thermal, and chemical analyses were evaluated. 3D scaffolds with an ideal pore size (~300 µm) for use in bone tissue engineering were generated. The addition of both bacterial cellulose (BC) and hydroxyapatite (HA) into PCL/GEL scaffold increased cell proliferation and attachment. PCL/GEL/BC/HA composite scaffolds provide a potential for bone tissue engineering applications.

Highly filled poly( l ‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

2020 ◽  
Vol 138 (2) ◽  
pp. 49662
Author(s):  
Gleb Dubinenko ◽  
Aleksey Zinoviev ◽  
Evgeny Bolbasov ◽  
Anna Kozelskaya ◽  
Evgeniy Shesterikov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Composite

3D printing of ceramic-based scaffolds for bone tissue engineering: an overview

2018 ◽  
Vol 6 (27) ◽  
pp. 4397-4412 ◽  
Author(s):  
Xiaoyu Du ◽  
Shengyang Fu ◽  
Yufang Zhu
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue

In this review, we systematically highlight the advances in 3D printing of ceramic-based scaffolds for bone tissue engineering.

scholarly journals 3D printing applications in bone tissue engineering

2020 ◽  
Vol 11 ◽  
pp. S118-S124 ◽  
Author(s):  
Abid Haleem ◽  
Mohd Javaid ◽  
Rizwan Hasan Khan ◽  
Rajiv Suman
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue

Zirconia toughened hydroxyapatite biocomposite formed by a DLP 3D printing process for potential bone tissue engineering

2019 ◽  
Vol 105 ◽  
pp. 110054 ◽  
Author(s):  
Jiancheng Zhang ◽  
Da Huang ◽  
Shuifeng Liu ◽  
Xianming Dong ◽  
Yiheng Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Printing Process

3D printing of PCL/nano-hydroxyapatite scaffolds derived from biogenic sources for bone tissue engineering

2021 ◽  
pp. e00318
Author(s):  
Francesca Cestari ◽  
Mauro Petretta ◽  
Yuejiao Yang ◽  
Antonella Motta ◽  
Brunella Grigolo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue

Via precise interface engineering towards bioinspired composites with improved 3D printing processability and mechanical properties

2017 ◽  
Vol 5 (25) ◽  
pp. 5037-5047 ◽  
Author(s):  
Felix Hanßke ◽  
Onur Bas ◽  
Cédryck Vaquette ◽  
Gernot Hochleitner ◽  
Jürgen Groll ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hybrid Materials ◽  
Elastic Moduli ◽  
Interface Engineering ◽  
Organic Hybrid ◽  
Biodegradable Composite

Precise interface engineering in inorganic–organic hybrid materials enhances both the elastic moduli and toughness of a biodegradable composite, which is of relevance for load-bearing applications in bone tissue engineering.

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