Gastric Cancer: Epigenetic Mechanisms: Aberrant DNA Methylation and Dysregulation of MicroRNA

2016 ◽  
pp. 257-267 ◽  
Author(s):  
Cheol Min Shin
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Epigenetic Mechanisms ◽  
Aberrant Dna Methylation

Risk Prediction of Gastric Cancer by Analysis of Aberrant DNA Methylation in Non-Neoplastic Gastric Epithelium

Digestion ◽  
2007 ◽  
Vol 75 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Tomomitsu Tahara ◽  
Tomiyasu Arisawa ◽  
Tomoyuki Shibata ◽  
Fang Yu Wang ◽  
Masakatsu Nakamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Risk Prediction ◽  
Gastric Epithelium ◽  
Aberrant Dna Methylation

scholarly journals Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer

2014 ◽  
Vol 13 (2) ◽  
pp. 4140-4145 ◽  
Author(s):  
J. Jin ◽  
L. Xie ◽  
C.H. Xie ◽  
Y.F. Zhou
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Aberrant Dna Methylation

scholarly journals Interleukin-1β increases the risk of gastric cancer through induction of aberrant DNA methylation in a mouse model

2016 ◽  
Vol 11 (4) ◽  
pp. 2919-2924 ◽  
Author(s):  
FUNG-YU HUANG ◽  
ANNIE ON-ON CHAN ◽  
ASIF RASHID ◽  
DANNY KA-HO WONG ◽  
WAI-KAY SETO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Mouse Model ◽  
Interleukin 1Β ◽  
Aberrant Dna Methylation

scholarly journals A Revolution in Dentistry: Epigenetics

2019 ◽  
Vol 07 (01) ◽  
pp. 001-005
Author(s):  
Namita Sepolia ◽  
Deepti Jindal ◽  
Sandhya Kaushwaha ◽  
Varun Jindal ◽  
Monika Negi
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Dna Methyltransferase ◽  
Cellular Proliferation ◽  
Cpg Islands ◽  
Odontogenic Tumors ◽  
Epigenetic Mechanisms ◽  
Epigenetic Changes ◽  
Daughter Cells ◽  
Aberrant Dna Methylation

AbstractEpigenetics is the study of potentially heritable changes in gene expression that does not involve changes in underlying DNA sequence. Epigenetic mechanisms play a crucial role in cellular proliferation, migration, and differentiation in both normal and neoplastic development. Epigenetic changes may be inherited and can occur during embryonal development or after birth. Once the change in DNA methylation takes place, following cell division the altered pattern is transferred into daughter cells by the action DNA methyltransferase enzyme, which recognizes hemi-methylated sites and methylates newly synthesized DNA formed during replication. Recently, it has been suggested that aberrant DNA methylation of cytosine-phosphate-guanine (CpG) islands is a common event in odontogenic tumors. Expression of DNA methyltransferase 1,3A,3B has been noted in various odontogenic tumors. Thus, this review aims to study the various epigenetic pathways that are altered in odontogenic tumors.

scholarly journals Long-term Changes In Aberrant DNA Methylation And Gastritis After Helicobacter Pylori Eradication Focused On Metachronous Gastric Cancer

2021 ◽  
Author(s):  
Ikko Tanaka ◽  
Shoko Ono ◽  
Yoshiyuki Watanabe ◽  
Hiroyuki Yamamoto ◽  
Ritsuko Oikawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Methylation Level ◽  
Aberrant Methylation ◽  
Long Term Changes ◽  
Metachronous Gastric Cancer ◽  
Aberrant Dna Methylation ◽  
H Pylori

Abstract BackgroundA persistently high methylation level in gastric mucosa after Helicobacter pylori (H. pylori) eradication is presumed to be a risk for metachronous gastric cancer (MGC); however, long-term changes in aberrant DNA methylation and histological gastritis have been unclear. Our aim was to examine changes in DNA methylation and histological gastritis according to the occurrence of MGC.MethodsSubjects were classified into 3 groups: 25 patients in whom metachronous gastric cancers occurred after the initial endoscopic resection (ER) for early gastric cancer and H. pylori eradication (MGC group), 17 patients in whom MGC did not occur for more than 5 years after initial ER and H. pylori eradication (non-MGC group) and 29 patients without a history of gastric cancer who succeeded in eradication more than 5 years ago (HP group). Aberrance of DNA methylation in 3 genes (miR-124a-3, EMX1, NKX6-1) and histological score of atrophy and intestinal metaplasia (IM) were evaluated using biopsy samples before and more than a mean of 5 years after H. pylori eradication.ResultsThe methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication. In the MGC group, H. pylori eradication did not improve aberrant methylation, and the Z-score significantly increased. There were significant positive correlations between methylation levels in miR-124a-3 and EMX1 and histological findings after eradication.ConclusionsA persistently high methylation level after H. pylori eradication reflected precancerous mucosal conditions and led to long-term MGC.

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