In Silico Approaches for Unearthing Bacterial Quorum-Sensing Inhibitors Against Pathogenic Bacteria

2019 ◽  
pp. 67-83
Author(s):  
Shrikant Pawar ◽  
Pallaval Veera Bramhachari ◽  
Chandrajit Lahiri
Keyword(s):  
Quorum Sensing ◽  
In Silico ◽  
Pathogenic Bacteria ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacterial Quorum Sensing During Infection

2020 ◽  
Vol 74 (1) ◽  
pp. 201-219 ◽  
Author(s):  
Sheyda Azimi ◽  
Alexander D. Klementiev ◽  
Marvin Whiteley ◽  
Stephen P. Diggle
Keyword(s):  
Quorum Sensing ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Human Infection ◽  
Future Research ◽  
Virulence Determinants ◽  
Plant Laboratory ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacteria are highly interactive and possess an extraordinary repertoire of intercellular communication and social behaviors, including quorum sensing (QS). QS has been studied in detail at the molecular level, so mechanistic details are well understood in many species and are often involved in virulence. The use of different animal host models has demonstrated QS-dependent control of virulence determinants and virulence in several human pathogenic bacteria. QS also controls virulence in several plant pathogenic species. Despite the role QS plays in virulence during animal and plant laboratory-engineered infections, QS mutants are frequently isolated from natural infections, demonstrating that the function of QS during infection and its role in pathogenesis remain poorly understood and are fruitful areas for future research. We discuss the role of QS during infection in various organisms and highlight approaches to better understand QS during human infection. This is an important consideration in an era of growing antimicrobial resistance, when we are looking for new ways to target bacterial infections.

scholarly journals The influence of bacterial quorum-sensing inhibitors against the formation of the diatom-biofilm

2016 ◽  
Vol 32 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Cuiyun Yang ◽  
Guojuan Song ◽  
Qi Zhu ◽  
Sujing Liu ◽  
Chuanhai Xia
Keyword(s):  
Quorum Sensing ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers

2019 ◽  
Author(s):  
Justin E. Silpe ◽  
Bonnie L. Bassler
Keyword(s):  
Quorum Sensing ◽  
Pathogenic Bacteria ◽  
Cell Communication ◽  
Signal Molecules ◽  
Host Bacterium ◽  
Gram Negative ◽  
Collective Behaviors ◽  
Bacterial Quorum Sensing ◽  
Genes Encoding ◽  
Bacterial Quorum

AbstractQuorum sensing (QS) is a process of cell-to-cell communication that bacteria use to orchestrate collective behaviors. QS relies on the cell-density-dependent production, accumulation, and receptor-mediated detection of extracellular signaling molecules called autoinducers (AIs). Gram-negative bacteria commonly use N-acyl homoserine lactones (AHLs) as their AIs and they are detected by LuxR-type receptors. Often, LuxR-type receptors are insoluble when not bound to a cognate AI. In this report, we show that LuxR-type receptors are encoded on phage genomes and, in the cases we tested, the phage LuxR-type receptors bind to and are solubilized specifically by the AHL AI produced by the host bacterium. We do not yet know the viral activities that are controlled by these phage QS receptors, however, our observations, coupled with recent reports, suggest that their occurrence is more widespread than previously appreciated. Using receptor-mediated detection of QS AIs could enable phages to garner information concerning the population density status of their bacterial hosts. We speculate that such information can be exploited by phages to optimize the timing of execution of particular steps in viral infection.ImportanceBacteria communicate with chemical signal molecules to regulate group behaviors in a process called quorum sensing (QS). In this report, we find that genes encoding receptors for Gram-negative bacterial QS communication molecules are present on genomes of viruses that infect these bacteria. These viruses are called phages. We show that two phage-encoded receptors, like their bacterial counterparts, bind to the communication molecule produced by the host bacterium, suggesting that phages can “listen in” on their bacterial hosts. Interfering with bacterial QS and using phages to kill pathogenic bacteria represent attractive possibilities for development of new antimicrobials to combat pathogens that are resistant to traditional antibiotics. Our findings of interactions between phages and QS bacteria need consideration as new antimicrobial therapies are developed.

Well-known quorum sensing inhibitors do not affect bacterial quorum sensing-regulated bean sprout spoilage

2007 ◽  
Vol 102 (3) ◽  
pp. 826-837 ◽  
Author(s):  
M. Rasch ◽  
T.B. Rasmussen ◽  
J.B. Andersen ◽  
T. Persson ◽  
J. Nielsen ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Bean Sprout ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Dihydropyrrolones as bacterial quorum sensing inhibitors

2019 ◽  
Vol 29 (9) ◽  
pp. 1054-1059 ◽  
Author(s):  
Basmah Almohaywi ◽  
Tsz Tin Yu ◽  
George Iskander ◽  
Daniel S.H. Chan ◽  
Kitty K.K. Ho ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Prospective bacterial quorum sensing inhibitors from Indian medicinal plant extracts

2017 ◽  
Vol 65 (1) ◽  
pp. 2-10 ◽  
Author(s):  
B.K. Tiwary ◽  
R. Ghosh ◽  
S. Moktan ◽  
V.K. Ranjan ◽  
P. Dey ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Indian Medicinal Plant ◽  
Quorum Sensing Inhibitors ◽  
Medicinal Plant Extracts ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Design, synthesis and evaluation of N-aryl-glyoxamide derivatives as structurally novel bacterial quorum sensing inhibitors

2016 ◽  
Vol 14 (2) ◽  
pp. 680-693 ◽  
Author(s):  
Shashidhar Nizalapur ◽  
Önder Kimyon ◽  
Nripendra Nath Biswas ◽  
Christopher R. Gardner ◽  
Renate Griffith ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Design Synthesis ◽  
Quorum Sensing Inhibitors ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacteria cooperatively regulate the expression of many phenotypes through a mechanism called quorum sensing (QS).

scholarly journals Use of Poly (ε-Lysine) Dendrons: A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Rahaf Issa ◽  
Steve T. Meikle ◽  
Stuart L. James ◽  
Ian R. Cooper
Keyword(s):  
Quorum Sensing ◽  
Biofilm Formation ◽  
Implantable Medical Devices ◽  
Quorum Sensing Inhibitors ◽  
Toxic Metabolites ◽  
Hyperbranched Poly ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Bacterial Replication ◽  
Virulence Factor Production

Pseudomonas aeruginosa is recognised as a major aetiological agent of nosocomial infections, which are associated with multiple-antibiotic resistance. Among many of its important virulence factors is its ability to form biofilms on the surfaces of implantable medical devices and to produce toxic metabolites, pyocyanin, via an intercellular cell density-dependent signalling system of communication. In this study, poly (ε-lysine) dendrons composed of increasingly branching generations were synthesised, characterised, and examined for their effects on virulence factor production in P. aeruginosa. The results show that these hyperbranched poly (ε-lysine) dendrons, in particular the 3rd generation, can increase the efficacy of a conventional antibiotic, ciprofloxacin, and reduce pyocyanin production, with marginal effects on the rate of bacterial replication, suggesting that the observed effects are not due to dendron toxicity. Furthermore, dendron and ciprofloxacin coadministration was identified as the most effective strategy which highlights the potential of peptide-based dendrons as quorum sensing inhibitors.

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