The 5? flanking DNA of a patatin gene directs tuber specific expression of a chimaeric gene in potato

1987 ◽  
Vol 9 (4) ◽  
pp. 345-375 ◽  
Author(s):  
David Twell ◽  
Gert Ooms
Keyword(s):  
Specific Expression ◽  
Patatin Gene

Isolation and glioma specific expression of MAGE-E1 gene

2000 ◽  
Vol 38 ◽  
pp. S126
Author(s):  
K Nakahira
Keyword(s):  
Specific Expression

Tissue-specific expression patterns of nuclear receptors

2013 ◽  
Author(s):  
AL Bookout ◽  
Y Jeong ◽  
M Downes ◽  
RT Yu ◽  
RM Evans ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Expression Patterns ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Probing the 14-3-3 Isoform-Specificity Profile of Interactions Stabilized by Fusicoccin A

2020 ◽  
Author(s):  
James Frederich ◽  
Ananya Sengupta ◽  
Josue Liriano ◽  
Ewa A. Bienkiewicz ◽  
Brian G. Miller
Keyword(s):  
Protein Interactions ◽  
Neurological Diseases ◽  
Adapter Proteins ◽  
Protein Protein Interactions ◽  
Specific Expression ◽  
Individual Client ◽  
Isoform Specificity ◽  
Fusicoccin A

Fusicoccin A (FC) is a fungal phytotoxin that stabilizes protein–protein interactions (PPIs) between 14-3-3 adapter proteins and their phosphoprotein interaction partners. In recent years, FC has emerged as an important chemical probe of human 14-3-3 PPIs implicated in cancer and neurological diseases. These previous studies have established the structural requirements for FC-induced stabilization of 14-3-3·client phosphoprotein complexes; however, the effect of different 14-3-3 isoforms on FC activity has not been systematically explored. This is a relevant question for the continued development of FC variants because there are seven distinct isoforms of 14-3-3 in humans. Despite their remarkable sequence and structural similarities, a growing body of experimental evidence supports both tissue-specific expression of 14-3-3 isoforms and isoform-specific functions <i>in vivo</i>. Herein, we report the isoform-specificity profile of FC <i>in vitro</i>using recombinant human 14-3-3 isoforms and a focused library of fluorescein-labeled hexaphosphopeptides mimicking the C-terminal 14-3-3 recognition domains of client phosphoproteins targeted by FC in cell culture. Our results reveal modest isoform preferences for individual client phospholigands and demonstrate that FC differentially stabilizes PPIs involving 14-3-3s. Together, these data provide strong motivation for the development of non-natural FC variants with enhanced selectivity for individual 14-3-3 isoforms.

Distinct tumor specific expression of TGFB4 ebaf a novel human gene of the TGF- szlig nbsp superfamily

10.2741/a158 ◽  
1997 ◽  
Vol 2 (1) ◽  
pp. a18-25 ◽  
Author(s):  
Siamak Tabibzadeh
Keyword(s):  
Human Gene ◽  
Specific Expression

Gender-Specific Expression of Arginine-Vasotocin in the Chicken Brain

2004 ◽  
Vol 15 (3) ◽  
pp. 219-223 ◽  
Author(s):  
R. Grossmann ◽  
A. Jurkevich ◽  
S. Klein
Keyword(s):  
Arginine Vasotocin ◽  
Specific Expression ◽  
Chicken Brain ◽  
Gender Specific
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