Distinct tumor specific expression of TGFB4 ebaf a novel human gene of the TGF- szlig nbsp superfamily

10.2741/a158 ◽  
1997 ◽  
Vol 2 (1) ◽  
pp. a18-25 ◽  
Author(s):  
Siamak Tabibzadeh
Keyword(s):  
Human Gene ◽  
Specific Expression

scholarly journals Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data

Genetics ◽  
2016 ◽  
Vol 204 (3) ◽  
pp. 1057-1064 ◽  
Author(s):  
Eun Yong Kang ◽  
Lisa J. Martin ◽  
Serghei Mangul ◽  
Warin Isvilanonda ◽  
Jennifer Zou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Nucleotide Polymorphisms ◽  
Human Gene ◽  
Nucleotide Polymorphisms ◽  
Rna Seq ◽  
Specific Expression ◽  
Single Nucleotide ◽  
Allele Specific Expression ◽  
Human Gene Expression ◽  
Allele Specific

Human Gene Therapy Harsh Lessons, High Hopes

2000 ◽  
Author(s):  
Larry Thompson
Keyword(s):  
Gene Therapy ◽  
Human Gene ◽  
Human Gene Therapy

Isolation and glioma specific expression of MAGE-E1 gene

2000 ◽  
Vol 38 ◽  
pp. S126
Author(s):  
K Nakahira
Keyword(s):  
Specific Expression

The Influence of Glycosylation on the Catalytic and Fibrinolytic Properties of Pro-Urokinase

1992 ◽  
Vol 68 (05) ◽  
pp. 539-544 ◽  
Author(s):  
Catherine Lenich ◽  
Ralph Pannell ◽  
Jack Henkin ◽  
Victor Gurewich
Keyword(s):  
Escherichia Coli ◽  
Mammalian Cell ◽  
Human Gene ◽  
Culture Media ◽  
Mammalian Cell Culture ◽  
Glycosylation Site ◽  
Clot Lysis ◽  
Cell Culture Media ◽  
E Coli ◽  
The Uk

SummaryWe previously found that human pro-UK expressed in Escherichia coli is more active in fibrinolysis than recombinant human pro-UK obtained from mammalian cell culture media. To determine whether this difference is related to the lack of glycosylation of the E. coli product, we compared the activity of E. coli-derived pro-UK [(-)pro-UK] with that of a glycosylated pro-UK [(+)pro-UK] and of a mutant of pro-UK missing the glycosylation site at Asn-302 [(-) (302) pro-UK]. The latter two pro-UKs were obtained by expression of the human gene in a mammalian cell. The nonglycosylated pro-UKs were activated by plasmin more efficiently (≈2-fold) and were more active in clot lysis (1.5-fold) than the (+)pro-UK. Similarly, the nonglycosylated two-chain derivatives (UKs) were more active against plasminogen and were more rapidly inactivated by plasma inhibitors than the (+)UK.These findings indicate that glycosylation at Asn-302 influences the activity of pro-UK/UK and could be the major factor responsible for the enhanced activity of E. coli-derived pro-UK.

Human gene therapy: a role for the primary care physician

1992 ◽  
Vol 1 (1) ◽  
pp. 113-120 ◽  
Author(s):  
C. J. Schmeichel
Keyword(s):  
Primary Care ◽  
Gene Therapy ◽  
Primary Care Physician ◽  
Human Gene ◽  
Care Physician ◽  
Human Gene Therapy

Tissue-specific expression patterns of nuclear receptors

2013 ◽  
Author(s):  
AL Bookout ◽  
Y Jeong ◽  
M Downes ◽  
RT Yu ◽  
RM Evans ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Expression Patterns ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
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