Effects of KT-362, a sarcolemmal and intracellular calcium antagonist, on calcium transients of cultured neonatal rat ventricular cells: A comparison with gallopamil and ryanodine

1997 ◽  
Vol 10 (6) ◽  
pp. 667-675 ◽  
Author(s):  
Youichi Tatsukawa ◽  
Makoto Arita
Keyword(s):  
Calcium Antagonist ◽  
Intracellular Calcium ◽  
Calcium Transients ◽  
Neonatal Rat ◽  
Ventricular Cells ◽  
Intracellular Calcium Antagonist

Hemodynamic and Electrocardiographic Actions of the New Intracellular Calcium Antagonist, KT-362, in the Conscious Dog

Pharmacology ◽  
1988 ◽  
Vol 37 (6) ◽  
pp. 376-384 ◽  
Author(s):  
Craig Hartman ◽  
Mahmood H. Al-Wathiqui ◽  
Harold L. Brooks ◽  
Garrett J. Gross ◽  
David C. Warltier
Keyword(s):  
Calcium Antagonist ◽  
Intracellular Calcium ◽  
Conscious Dog ◽  
Intracellular Calcium Antagonist

Development of instrumentation to measure rapid calcium transits in neonatal rat ventricular myocytes

1988 ◽  
Vol 46 ◽  
pp. 44-45
Author(s):  
H. K. Hagler ◽  
A. C. Morris ◽  
L. M. Buja
Keyword(s):  
Intracellular Calcium ◽  
Cell Injury ◽  
Ventricular Myocytes ◽  
Calcium Transients ◽  
Neonatal Rat ◽  
Free Calcium ◽  
Total Calcium ◽  
X Ray ◽  
Calcium Indicators ◽  
Electron Microscopes

Changes in the intracellular calcium levels in cardiac myocytes are important in the regulation of normal cardiac function and have been implicated in contributing to irreversible cell injury with ischemia or hypoxia. Intracellular measurement of total calcium changes with subcellular resolution have become routine using rapid cryofixation, cryosectioning, cryotransfer and energy dispersive x-ray microanalysis in analytical electron microscopes. The x-ray microanalysis technique measures total calcium changes within subcellular compartments, but does not distinguish between the bound and free calcium. With the successful development of fluorescent calcium indicators which may be introduced into cells without significantly buffering the intracellular calcium levels, it has become possible to measure rapid calcium transients during contraction. The primary requirements in the development of a system to utilize the fluorescent calcium indicators were to resolve calcium transients in individual cells (since the response to perturbations such as hypoxia is heterogeneous) and develop a system which would be flexible enough to accommodate new indicators as they become available.

HA1004, an Intracellular Calcium Antagonist, Selectively Attenuates Pulmonary Hypertension in Newborn Lambs

1994 ◽  
Vol 23 (5) ◽  
pp. 806-813 ◽  
Author(s):  
Mark R. Crowley ◽  
Jeffrey R. Fineman ◽  
Scott J. Soifer
Keyword(s):  
Pulmonary Hypertension ◽  
Calcium Antagonist ◽  
Intracellular Calcium ◽  
Intracellular Calcium Antagonist

Arachidonic acid inhibits electrically induced intracellular calcium transients in neonatal rat cardiomyocytes

1993 ◽  
Vol 49 (5) ◽  
pp. 837-838 ◽  
Author(s):  
P. Hoffmann ◽  
D. Richards ◽  
P. Plews ◽  
I. Hoffmann-Heinroth ◽  
M. Toraason
Keyword(s):  
Arachidonic Acid ◽  
Intracellular Calcium ◽  
Calcium Transients ◽  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes

scholarly journals Effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Chen Zhang ◽  
Xiao-Li Shan ◽  
Yue-Ling Liao ◽  
Pei Zhao ◽  
Wei Guo ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Cardiac Myocytes ◽  
Calcium Transients ◽  
Neonatal Rat ◽  
Neonatal Rat Cardiac Myocytes ◽  
Rat Cardiac Myocytes

Effects of HA1077, an intracellular calcium antagonist, on neurotransmitter metabolism in rat brainIn Vivo

1991 ◽  
Vol 6 (3) ◽  
pp. 111-124 ◽  
Author(s):  
Yasushi Kondoh ◽  
Shigenori Mizusawa ◽  
Matsutaro Murakami ◽  
Ken Nagata ◽  
Hiroyuki Nakamichi ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Intracellular Calcium ◽  
Intracellular Calcium Antagonist ◽  
Neurotransmitter Metabolism
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