Effects of benzoylphenyl ureas on growth of B16 melanoma cells in vitro and in vivo

1991 ◽  
Vol 9 (3) ◽  
Author(s):  
HendricusP. Hofs ◽  
J.Gordon McVie
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells ◽  
Benzoylphenyl Ureas

In vitro and in vivo Enhancement of Vincristine Antitumor Activity on B16 Melanoma Cells by Calcium Antagonist Flunarizine

Oncology ◽  
1987 ◽  
Vol 44 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Alberto Bellelli ◽  
Claudia Camboni ◽  
Giovanna de Luca ◽  
Mario Materazzi ◽  
Manlio Mattioni ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Antitumor Activity ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: In vitro and in vivo study

2008 ◽  
Vol 46 (5) ◽  
pp. 1825-1833 ◽  
Author(s):  
Lj. Harhaji ◽  
S. Mijatović ◽  
D. Maksimović-Ivanić ◽  
I. Stojanović ◽  
M. Momčilović ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Coriolus Versicolor ◽  
In Vivo Study ◽  
B16 Melanoma Cells

Artocarpus Plants as a Potential Source of Skin Whitening Agents

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Enos Tangke Arung ◽  
Kuniyoshi Shimizu ◽  
Ryuichiro Kondo
Keyword(s):  
Inhibitory Activity ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Vitro Assay ◽  
Skin Whitening ◽  
Melanin Formation ◽  
B16 Melanoma Cells ◽  
Structure Activity

Artocarpus plants have been a focus of constant attention due to the potential for skin whitening agents. In the in vitro experiment, compounds from the Artocarpus plants, such as artocarpanone, norartocarpetin, artocarpesin, artogomezianol, andalasin, artocarbene, and chlorophorin showed tyrosinase inhibitory activity. Structure-activity investigations revealed that the 4-substituted resorcinol moiety in these compounds was responsible for their potent inhibitory activities on tyrosinase. In the in vitro assay, using B16 melanoma cells, the prenylated polyphenols isolated from Artocarpus plants, such as artocarpin, cudraflavone C, 6-prenylapigenin, kuwanon C, norartocarpin, albanin A, cudraflavone B, and brosimone I showed potent inhibitory activity on melanin formation. Structure-activity investigations revealed that the introduction of an isoprenoid moiety to a non-isoprenoid-substituted polyphenol enhanced the inhibitory activity of melanin production in B16 melanoma cells. In the in vivo investigation, the extract of the wood of Artocarpus incisus and a representative isolated compound from it, artocarpin had a lightening effect on the skin of guinea pigs’ backs. Other in vivo experiments using human volunteers have shown that water extract of Artocarpus lakoocha reduced the melanin formation in the skin of volunteers. These results indicate that the extracts of Artocarpus plants are potential sources for skin whitening agents.

Enhanced In Vivo Sensitivity of In Vitro Interferon-Treated B16 Melanoma Cells to CD8 Cells and Activated Macrophages

1996 ◽  
Vol 16 (10) ◽  
pp. 805-812 ◽  
Author(s):  
CHRISTINA M. FLEISCHMANN ◽  
G. JOHN STANTON ◽  
W. ROBERT FLEISCHMANN
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Activated Macrophages ◽  
Cd8 Cells ◽  
B16 Melanoma Cells

TNF Impairs In Vivo and In Vitro Natural Killer (NK) Susceptibility of B16 Melanoma Cells

1992 ◽  
Vol 35 (3) ◽  
pp. 279-287 ◽  
Author(s):  
G. PALMIERI ◽  
S. MORRONE ◽  
P.-L. LOLLINI ◽  
C. GIOVANNI ◽  
G. NICOLETTI ◽  
...  
Keyword(s):  
Natural Killer ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

scholarly journals Tyrosinase activity and melanogenic effects of Lespedeza bicolor extract in vitro and in vivo

BioResources ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 6244-6261
Author(s):  
Si Young Ha ◽  
Ji Young Jung ◽  
Hee Young Kang ◽  
Tae-Heung Kim ◽  
Jae-Kyung Yang
Keyword(s):  
Ethanol Extract ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Tyrosinase Activity ◽  
Melanin Content ◽  
B16 Melanoma Cells ◽  
Notable Increase ◽  
Lespedeza Bicolor

Lespedeza bicolor (L. bicolor) is used for medicinal purposes because of its various biological and pharmacological activities. In this study, the effects of L. bicolor ethanol extract on the treatment of vitiligo were investigated. The determination of melanin content in melanocytes was measured using B16 melanoma cells and C57BL/6J Ler-vit/vit mice. Finally, the quercetin content in L. bicolor were qualitatively analyzed using HPLC. The results obviously indicated that the L. bicolor extract enhanced melanogenesis and increased tyrosinase activity in cultured melanoma cells and C57BL/6J Ler-vit/vit mice. Treatment with L. bicolor extract led to a higher content of melanin and eumelanin in C57BL/6J Ler-vit/vit mice hair than in control (untreated) mice, which demonstrated the therapeutic effect of hair-graying associated with vitiligo. There was a notable increase in melanocytes in the skin of C57BL/6J Ler-vit/vit mice treated with L. bicolor extract compared with the control. L. bicolor extract was a potent tyrosinase and melanin synthesis activator in B16 melanoma cells. C57BL/6J Ler-vit/vit mice treated with L. bicolor extract had significantly higher melanin content in hair than the untreated control. The results suggest that L. bicolor extract is a potential alternative treatment for improvement of vitiligo.

scholarly journals Fully Phosphorothioate-Modified CpG ODN with PolyG Motif Inhibits the Adhesion of B16 Melanoma Cells In Vitro and Tumorigenesis In Vivo

2013 ◽  
Vol 23 (4) ◽  
pp. 253-263 ◽  
Author(s):  
Xueju Wang ◽  
Liying Wang ◽  
Min Wan ◽  
Xiuli Wu ◽  
Yongli Yu ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Cpg Odn ◽  
B16 Melanoma Cells

scholarly journals Metastatic potential of B16 melanoma cells after in vitro selection for organ-specific adherence.

1985 ◽  
Vol 101 (3) ◽  
pp. 720-724 ◽  
Author(s):  
P A Netland ◽  
B R Zetter
Keyword(s):  
Tumor Cells ◽  
Lung Tissue ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Primary Tumors ◽  
B16 Melanoma Cells ◽  
Specific Host ◽  
Cryostat Sections

Heterogeneous primary tumors contain subpopulations of cells that differ in ability to metastasize to specific host organs. We have used cryostat sections of host organs to select for metastatic variants of B16 melanoma cells with increased adhesion to specific syngeneic tissues. By repeating the selection procedure with lung tissue, a subpopulation of cells was isolated that demonstrated a specific increase in binding to cryostat sections of mouse lung. This altered binding was reflected by a sixfold increase in the frequency of lung metastasis 21 d after tail vein injection of the tumor cells. In contrast, B16 melanoma cells selected on cryostat sections of mouse brain showed no increase in adhesion to brain or lung tissue and the metastatic pattern in vivo was not significantly different compared with the parent cell line. When cells selected for increased adhesion to cryostat sections of lung were further examined in vitro, they showed altered morphology and increased motility but no change in growth rate. These results demonstrate that alterations in the adhesive interactions between metastatic tumor cells and a specific host tissue can directly affect the frequency of metastasis to that tissue in vivo.

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