Light microscopic histochemistry of the postnatal development and localization of carbonic anhydrase activity in glial and neuronal cell types of the rat central nervous system

1990 ◽  
Vol 94 (4) ◽  
Author(s):  
A. N�gr�di ◽  
A. Mih�ly
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Carbonic Anhydrase ◽  
Postnatal Development ◽  
Neuronal Cell ◽  
Cell Types ◽  
Carbonic Anhydrase Activity

Substituted thiadiazolines as inhibitors of central nervous system carbonic anhydrase

1975 ◽  
Vol 18 (4) ◽  
pp. 351-354 ◽  
Author(s):  
James J. Lukes ◽  
Karl A. Nieforth
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Carbonic Anhydrase

GAP-43 gene expression during postnatal development in the central nervous system of macaque monkey

1994 ◽  
Vol 19 ◽  
pp. S121 ◽  
Author(s):  
Takao Oishi ◽  
Keiji Matsuda ◽  
Noriyuki Higo ◽  
Yumiko Umino ◽  
Motoharu Hayashi
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Postnatal Development ◽  
Macaque Monkey ◽  
The Central Nervous System

Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system

1996 ◽  
Vol 109 (7) ◽  
pp. 1749-1757 ◽  
Author(s):  
N. Soussi-Yanicostas ◽  
J.P. Hardelin ◽  
M.M. Arroyo-Jimenez ◽  
O. Ardouin ◽  
R. Legouis ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Extracellular Matrix ◽  
Nervous System ◽  
Cell Membrane ◽  
Heparan Sulfate ◽  
Matrix Protein ◽  
Neuronal Cell ◽  
Extracellular Matrix Protein ◽  
Cell Populations

The KAL gene is responsible for the X-chromosome linked form of Kallmann's syndrome in humans. Upon transfection of CHO cells with a human KAL cDNA, the corresponding encoded protein, KALc, was produced. This protein is N-glycosylated, secreted in the cell culture medium, and is localized at the cell surface. Several lines of evidence indicate that heparan-sulfate chains of proteoglycan(s) are involved in the binding of KALc to the cell membrane. Polyclonal and monoclonal antibodies to the purified KALc were generated. They allowed us to detect and characterize the protein encoded by the KAL gene in the chicken central nervous system at late stages of embryonic development. This protein is synthesized by definite neuronal cell populations including Purkinje cells in the cerebellum, mitral cells in the olfactory bulbs and several subpopulations in the optic tectum and the striatum. The protein, with an approximate molecular mass of 100 kDa, was named anosmin-1 in reference to the deficiency of the sense of smell which characterizes the human disease. Anosmin-1 is likely to be an extracellular matrix component. Since heparin treatment of cell membrane fractions from cerebellum and tectum resulted in the release of the protein, we suggest that one or several heparan-sulfate proteoglycans are involved in the binding of anosmin-1 to the membranes in vivo.

scholarly journals Detection and Characterization of Autoantibodies to Neuronal Cell-Surface Antigens in the Central Nervous System

2016 ◽  
Vol 9 ◽  
Author(s):  
Marleen H. van Coevorden-Hameete ◽  
Maarten J. Titulaer ◽  
Marco W. J. Schreurs ◽  
Esther de Graaff ◽  
Peter A. E. Sillevis Smitt ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Surface ◽  
Neuronal Cell ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
The Central Nervous System
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