Gc (vitamin D binding protein) subtypes in rheumatoid arthritis

1985 ◽  
Vol 70 (3) ◽  
Author(s):  
S.S. Papiha ◽  
B. Pal
2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Sabine Blaschke ◽  
Kathinka Rinke ◽  
Michael Maring ◽  
Thomas Flad ◽  
Susann Patschan ◽  
...  

2019 ◽  
Vol 20 (18) ◽  
pp. 4368 ◽  
Author(s):  
Mun ◽  
Lee ◽  
Park ◽  
Kim ◽  
Lee ◽  
...  

Rheumatoid arthritis is an autoimmune disease that causes serious functional loss in patients. Early and accurate diagnosis of rheumatoid arthritis may attenuate its severity. Despite a diagnosis guideline in the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis, the practical difficulties in its diagnosis highlight the need of developing new methods for diagnosing rheumatoid arthritis. The current study aimed to identify rheumatoid arthritis diagnostic biomarkers by using a proteomics approach. Serum protein profiling was conducted using mass spectrometry, and five distinguishable biomarkers were identified therefrom. In the validation study, the five biomarkers were quantitatively verified by multiple reaction monitoring (MRM) analysis. Two proteins, namely serum amyloid A4 and vitamin D binding protein, showed high performance in distinguishing patients with rheumatoid arthritis from healthy controls. Logistic analysis was conducted to evaluate how accurately the two biomarkers distinguish patients with rheumatoid arthritis from healthy controls. The classification accuracy was 86.0% and 81.4% in patients with rheumatoid arthritis and in healthy controls, respectively. Serum amyloid A4 and vitamin D binding protein could be potential biomarkers related to the inflammatory response and joint destruction that accompany rheumatoid arthritis.


2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Mikael Brink ◽  
Linda Johansson ◽  
Evelina Nygren ◽  
Lisbeth Ärlestig ◽  
Johan Hultdin ◽  
...  

2016 ◽  
Author(s):  
Evelyn Hsieh ◽  
Liana Fraenkel ◽  
Yang Han ◽  
Weibo Xia ◽  
Karl Insogna ◽  
...  

2016 ◽  
Author(s):  
Evelyn Hsieh ◽  
Liana Fraenkel ◽  
Yang Han ◽  
Weibo Xia ◽  
Karl Insogna ◽  
...  

2019 ◽  
Author(s):  
Ankana Ganguly ◽  
Alexandra Shattock ◽  
Annsha Joseph ◽  
Janesh Gupta ◽  
Martin Hewison

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