DNA polymerase δ is required for the replication feedback control of cell cycle progression in Schizosaccharomyces pombe

1995 ◽  
Vol 246 (5) ◽  
pp. 561-569 ◽  
Author(s):  
Stefania Francesconi ◽  
Anne-Marie De Recondo ◽  
Giuseppe Baldacci
Keyword(s):  
Cell Cycle ◽  
Feedback Control ◽  
Schizosaccharomyces Pombe ◽  
Dna Polymerase ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Dna Polymerase Δ

scholarly journals The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

Cell Cycle ◽  
2013 ◽  
Vol 13 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Marietta Y.W.T. Lee ◽  
Sufang Zhang ◽  
Szu Hua Lin ◽  
Xiaoxiao Wang ◽  
Zbigniew Darzynkiewicz ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Polymerase ◽  
Cell Cycle Progression ◽  
Ubiquitin Ligases ◽  
Cycle Progression ◽  
Dna Polymerase Δ

scholarly journals The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.

1996 ◽  
Vol 15 (19) ◽  
pp. 5268-5279 ◽  
Author(s):  
H. Yamano ◽  
J. Gannon ◽  
T. Hunt
Keyword(s):  
Cell Cycle ◽  
Schizosaccharomyces Pombe ◽  
Cell Cycle Progression ◽  
Cycle Progression

Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe

1992 ◽  
Vol 102 (1) ◽  
pp. 43-53 ◽  
Author(s):  
W. Krek ◽  
J. Marks ◽  
N. Schmitz ◽  
E.A. Nigg ◽  
V. Simanis
Keyword(s):  
Cell Cycle ◽  
Schizosaccharomyces Pombe ◽  
Cell Cycle Arrest ◽  
Fission Yeast ◽  
Cell Cycle Progression ◽  
Atp Binding ◽  
In Vitro Mutagenesis ◽  
Cycle Progression ◽  
Cycle Arrest ◽  
P34 Cdc2

We have used the fission yeast Schizosaccharomyces pombe to analyse the effects of in vitro mutagenesis of the four known phosphorylation sites in the chicken p34(cdc2) protein, Thr 14, Tyr 15, Thr 161 and Ser 277, upon cell cycle progression. We have studied both the effect of overexpression of mutant proteins in a cdc2+ background and assayed their ability to rescue null and temperature-sensitive alleles of cdc2. Mutations of Thr 14 and Tyr 15 within the ATP binding domain of p34(cdc2) that mimic constitutive phosphorylation cause dominant negative cell cycle arrest when overexpressed. In contrast, some substitutions that simulate permanent dephosphorylation of the corresponding sites advance dephosphorylation of the corresponding sites advance mitosis. These data confirm the model that p34(cdc2) function is negatively regulated by phosphorylation of residues in the ATP binding site. Mutagenesis of the conserved residue Thr 161 functionally inactivates p34(cdc2), and our data suggest that both phosphorylation and dephosphorylation events at Thr 161 are required for progression through the cell cycle. Mutations at the fourth site of phosphorylation. Ser 277, lead to cold-sensitive cell cycle arrest, in minimal but not rich growth medium, suggesting that this site is involved in monitoring the nutritional status of the cell.

scholarly journals Characterization of the effects of cisplatin and carboplatin on cell cycle progression and DNA damage response activation in DNA polymerase eta-deficient human cells

Cell Cycle ◽  
2009 ◽  
Vol 8 (18) ◽  
pp. 3043-3054 ◽  
Author(s):  
Séverine Cruet-Hennequart ◽  
Sangamitra Villalan ◽  
Agnieszka Kaczmarczyk ◽  
Elaine O’Meara ◽  
Anna M. Sokol ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Polymerase ◽  
Dna Damage Response ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Polymerase Eta ◽  
Dna Polymerase Eta ◽  
Damage Response ◽  
Response Activation
Sign in / Sign up

Export Citation Format

Share Document