The central effects of paraoxon on blood pressure of rabbits after intravenous administration or infusion via a vertebral artery

1982 ◽  
Vol 50-50 (3-4) ◽  
pp. 241-247 ◽  
Author(s):  
Joost H. de Neef ◽  
Arvid Manneke ◽  
Arijan J. Porsius
Keyword(s):  
Blood Pressure ◽  
Vertebral Artery ◽  
Intravenous Administration ◽  
Central Effects

D-Dimer As An Indicator of Vertebral Artery Dissection: A Case Control Study

2021 ◽  
Author(s):  
Atsuyuki Watanabe ◽  
Hiroshi Ito ◽  
Kazushi Maruo ◽  
Junzo Nakao ◽  
Takako Kaino ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Neck Pain ◽  
Vertebral Artery ◽  
Laboratory Data ◽  
Vertebral Artery Dissection ◽  
Young Patients ◽  
Artery Dissection ◽  
Diagnostic Model ◽  
Common Symptom ◽  
D Dimer

Abstract Background Vertebral artery dissection (VAD), which can possibly lead to stroke, presents various symptoms such as headache, neck pain, transient ischemic attacks, and vertigo. We evaluated the effect of D-dimer to distinguish VAD from benign diseases by retrospective single-center observational study. Methods All VAD cases received in the emergency department between January 2013 and June 2020 were reviewed. Comparing those cases to vertigo with benign etiologies, the correlation between VAD and D-dimer was analyzed. Using stepwise multivariate logistic regression, possible symptoms to suspect VAD were also determined from physical findings and some laboratory data, including D-dimer. Results Eleven patients were included in the VAD group, and 59 patients were enrolled in the control (benign vertigo [BV]) group. The most common symptom in VAD patients was hemiplegia (N = 7, 63.6%) and cranial neuropathy (N = 7, 63.6%), followed by classic occipital or posterior neck pain (N = 4, 36.4%), gait ataxia (N = 3, 27.3%), and confusion (N = 1, 9.1%). Two patients (18.2%) were free from any symptoms except vertigo. D-dimer was not significantly different between the two groups at the positive cutoff value of 500 ng/mL (p = 1). By stepwise selection, age (odds ratio (OR): 0.92, [0.87–0.98], p < 0.01) and systolic blood pressure (sBP; OR: 1.06 [1.02–1.10], p < 0.01) were selected in the diagnostic model. In combination, age under 60 and sBP over 160 mmHg yielded 63.6% sensitivity, 98.3% specificity, and 37.5 positive likelihood ratio. Conclusions In our study, D-dimer was not found to be an effective indicator of VAD. By contrast, disproportionate hypertension (high blood pressure in young patients) can be a key factor to suspect VAD. Future studies with larger sample sizes are warranted.

The response of animals to suxamethonium (succinyldicholine) and succinylmonocholine

1991 ◽  
Vol 62 (3) ◽  
pp. 126-129
Author(s):  
J. Hattingh ◽  
N. I. Pitts ◽  
V. De Vos ◽  
D. G. Moyes ◽  
M. F. Ganhao
Keyword(s):  
Blood Pressure ◽  
Respiratory Rate ◽  
Intravenous Administration ◽  
Acetylcholine Receptors ◽  
Loxodonta Africana ◽  
Breakdown Product ◽  
Blood Gas ◽  
Syncerus Caffer ◽  
African Elephants ◽  
Respiratory Responses

The time which elapses before cessation of breathing, and blood pressure and blood gas changes after the intramuscular administration of suxamethonium, or a mixture of suxamethonium and hexamethonium, is compared in immobilised African elephants (Loxodonta africana) and buffaloes (Syncerus caffer). In addition, the respiratory responses of elephants and other animals to intravenous administration of suxamethonium and succinylmonocholine are reported on, as are the effects of darting animals with succinylmonocholine. The results show that respiration is affected in a similar fashion in all species investigated. However, the characteristic gradual decrease in respiratory rate seen in elephants during culling, using suxamethonium, resembles the effects observed when succinylmonocholine is administered. It is suggested that elephants are killed by this first breakdown product of suxamethonium during culling and/or that unique acetylcholine receptors may be involved.

CENTRAL EFFECTS OF ARGININE VASOPRESSIN ON BLOOD PRESSURE IN RATS

Endocrinology ◽  
1982 ◽  
Vol 110 (3) ◽  
pp. 1058-1060 ◽  
Author(s):  
QUENTIN J. PITTMAN ◽  
DUNCAN LAWRENCE ◽  
LYNN McLEAN
Keyword(s):  
Blood Pressure ◽  
Arginine Vasopressin ◽  
Central Effects

The effect of stenting on blood pressure in hypertensive patients with symptomatic proximal subclavian or vertebral artery stenosis

2019 ◽  
Vol 95 (S1) ◽  
pp. 633-640
Author(s):  
Wuqiang Che ◽  
Hui Dong ◽  
Xiongjing Jiang ◽  
Hongliang Xiong ◽  
Yang Chen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vertebral Artery ◽  
Artery Stenosis ◽  
Hypertensive Patients ◽  
Vertebral Artery Stenosis

The Site of Cardiovascular Action of Angiotensin II in the Brain

1970 ◽  
Vol 39 (2) ◽  
pp. 327-336 ◽  
Author(s):  
M. D. Joy ◽  
R. D. Lowe
Keyword(s):  
Spinal Cord ◽  
Vertebral Artery ◽  
Basilar Artery ◽  
Cardiovascular Response ◽  
Cervical Cord ◽  
Central Effects ◽  
Small Arteries ◽  
Site Of Action ◽  
Cervical Segment ◽  
The Brain

1. The site of action of vertebral artery infusions of angiotensin was studied in the chloralose-anaesthetized greyhound. 2. The cardiovascular response to vertebral artery infusion of angiotensin (0·25–2·0 ng kg−1 min−1) was not reduced by clamping the basilar artery between the pons and the pyramidal decussation. There was no response to infusion of angiotensin through a catheter inserted in a rostral direction into the basilar artery above the clamp. The site of action must therefore lie caudal to the pons. 3. Transection of the spinal cord at the first cervical segment did not abolish the response to vertebral artery infusions, which was still mediated by the vagus nerve and abolished by subsequent vagotomy. The site of action must therefore lie rostral to the cervical cord. 4. Local infusions of angiotensin into the small arteries supplying the medulla produced a response similar to that obtained with vertebral artery infusion of angiotensin. 5. These results indicate that the site responsible for these central effects of angiotensin lies in the medulla.

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