An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism

1993 ◽  
Vol 85 (4) ◽  
pp. 445-448 ◽  
Author(s):  
K. Hayashida ◽  
S. Oyanagi ◽  
Y. Mizutani ◽  
M. Yokochi
Keyword(s):  
Substantia Nigra ◽  
Ultrastructural Study ◽  
Lewy Body ◽  
Autopsy Case ◽  
Juvenile Parkinsonism ◽  
Cytoplasmic Change

Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis

1989 ◽  
Vol 78 (2) ◽  
pp. 143-152 ◽  
Author(s):  
S. Murayama ◽  
Y. Ookawa ◽  
H. Mori ◽  
I. Nakano ◽  
Y. Ihara ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Ultrastructural Study ◽  
Lewy Body ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Hyaline Inclusions ◽  
Lateral Sclerosis

An atypical autopsy case of Lewy Body disease with clinically diagnosed major depression: A clinical, radiological and pathological study

2008 ◽  
Vol 0 (0) ◽  
pp. 080410085159654-??? ◽  
Author(s):  
Shuji Iritani ◽  
Kuniaki Tsuchiya ◽  
Tetsuaki Arai ◽  
Haruhiko Akiyama ◽  
Kenji Ikeda
Keyword(s):  
Major Depression ◽  
Lewy Body ◽  
Lewy Body Disease ◽  
Autopsy Case ◽  
Pathological Study

HUNTER'S SYNDROME. An Ultrastructural Study of an Autopsy Case

1988 ◽  
Vol 38 (9) ◽  
pp. 1175-1190
Author(s):  
Hideaki Oda ◽  
Yoshiro Sasaki ◽  
Yukio Nakatani ◽  
Hatae Maesaka ◽  
Seizo Suwa
Keyword(s):  
Ultrastructural Study ◽  
Autopsy Case ◽  
Hunter's Syndrome

Giant Cell Pneumonia: Light Microscopy, Immunohistochemical, and Ultrastructural Study of an Autopsy Case

1996 ◽  
Vol 20 (6) ◽  
pp. 585-591 ◽  
Author(s):  
Sheikh Mizanur Rahman ◽  
Hideaki Eto ◽  
Syed Ahmed Morshed ◽  
Hideyo Itakura
Keyword(s):  
Light Microscopy ◽  
Giant Cell ◽  
Ultrastructural Study ◽  
Autopsy Case

Amyotrophic lateral sclerosis with dementia showing clinical parkinsonism and severe degeneration of the substantia nigra: Report of an autopsy case

2007 ◽  
Vol 27 (3) ◽  
pp. 295-299 ◽  
Author(s):  
Masayuki Shintaku ◽  
Kiyomitsu Oyanagi ◽  
Daita Kaneda
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Substantia Nigra ◽  
Autopsy Case ◽  
Lateral Sclerosis

scholarly journals Active lifestyle enhances protein expression profile in subjects with Lewy body pathology

2021 ◽  
Vol 15 (1) ◽  
pp. 41-50
Author(s):  
Caroline Cristiano Real ◽  
Cláudia Kimie Suemoto ◽  
Karina Henrique Binda ◽  
Lea Tenenholz Grinberg ◽  
Carlos Augusto Pasqualucci ◽  
...  
Keyword(s):  
Physical Activity ◽  
Basal Ganglia ◽  
Substantia Nigra ◽  
Protein Expression ◽  
Lewy Body ◽  
Postmortem Brain ◽  
Active Lifestyle ◽  
Positive Effects ◽  
Lewy Body Pathology ◽  
Postmortem Brain Tissue

ABSTRACT. Clinical trials of the effects of physical activity have reported improvements in symptoms and quality of life in patients with Parkinson's disease (PD). Additionally, morphological brain changes after exercising were reported in PD animal models. However, these lifestyle-related changes were not evaluated in postmortem brain tissue. Objective: We aimed to evaluate, by immunohistochemistry, astrocytes, tyrosine hydroxylase (TH) and structural proteins expression (neurofilaments and microtubules — MAP2) changes in postmortem brain samples of individuals with Lewy body pathology. Methods: Braak PD stage≥III samples, classified by neuropathology analysis, from The Biobank for Aging Studies were classified into active (n=12) and non-active (n=12) groups, according to physical activity lifestyle, and paired by age, sex and Braak staging. Substantia nigra and basal ganglia were evaluated. Results: Groups were not different in terms of age or gender and had similar PD neuropathological burden (p=1.00). We observed higher TH expression in the active group in the substantia nigra and the basal ganglia (p=0.04). Astrocytes was greater in the non-active subjects in the midbrain (p=0.03) and basal ganglia (p=0.0004). MAP2 levels were higher for non-active participants in the basal ganglia (p=0.003) and similar between groups in the substantia nigra (p=0.46). Neurofilament levels for non-active participants were higher in the substantia nigra (p=0.006) but not in the basal ganglia (p=0.24). Conclusion: Active lifestyle seems to promote positive effects on brain by maintaining dopamine synthesis and structural protein expression in the nigrostriatal system and decrease astrogliosis in subjects with the same PD neuropathology burden.

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