Donor-recipient age difference?an independent risk factor in cyclosporin-treated renal transplant recipients

1991 ◽  
Vol 4 (2) ◽  
pp. 88-91 ◽  
Author(s):  
Peter Donnelly ◽  
Peter Veitch ◽  
Peter Bell ◽  
Robin Henderson ◽  
Paul Oman ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Transplant ◽  
Independent Risk Factor ◽  
Age Difference ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Recipient Age

Donor-recipient age difference - an independent risk factor in cyclosporin-treated renal transplant recipients

1991 ◽  
Vol 4 (1) ◽  
pp. 88-91
Author(s):  
Peter Donnelly ◽  
Peter Veitch ◽  
Peter Bell ◽  
Robin Henderson ◽  
Paul Oman ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Transplant ◽  
Independent Risk Factor ◽  
Age Difference ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Recipient Age

Hyperhomocyst(e)inemia as an independent risk factor for cardiovascular disease in renal transplant recipients

1998 ◽  
Vol 65 (12) ◽  
pp. S75
Author(s):  
Didier DUCLOUX ◽  
Christophe RUEDIN ◽  
Roger GIBEY ◽  
Jean-Michel REBIBOU ◽  
Catherine BRESSON-VAUTRIN ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Renal Transplant ◽  
Independent Risk Factor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Sclerostin is an independent risk factor for all-cause mortality in kidney transplant recipients

2020 ◽  
Vol 24 (12) ◽  
pp. 1177-1183
Author(s):  
Shufei Zeng ◽  
Torsten Slowinski ◽  
Wolfgang Pommer ◽  
Ahmed A. Hasan ◽  
Mohamed M. S. Gaballa ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Transplant ◽  
Kidney Transplant ◽  
Independent Risk Factor ◽  
Cox Regression ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Kaplan Meier ◽  
All Cause Mortality

Abstract Background Sclerostin is a hormone contributing to the bone-vascular wall cross talk and has been implicated in cardiovascular events and mortality in patients with chronic kidney disease (CKD). We analyzed the relationship between sclerostin and mortality in renal transplant recipients. Methods 600 stable renal transplant recipients (367men, 233 women) were followed for all-cause mortality for 3 years. Blood and urine samples for analysis and clinical data were collected at study entry. We performed Kaplan–Meier survival analysis and Cox regression models considering confounding factors such as age, eGFR, cold ischemia time, HbA1c, phosphate, calcium, and albumin. Optimal cut-off values for the Cox regression model were calculated based on ROC analysis. Results Sixty-five patients died during the observation period. Nonsurvivors (n = 65; sclerostin 57.31 ± 30.28 pmol/L) had higher plasma sclerostin levels than survivors (n = 535; sclerostin 47.52 ± 24.87 pmol/L) (p = 0.0036). Kaplan–Meier curve showed that baseline plasma sclerostin concentrations were associated with all-cause mortality in stable kidney transplant recipients (p = 0.0085, log-rank test). After multiple Cox regression analysis, plasma levels of sclerostin remained an independent predictor of all-cause mortality (hazard ratio, 1.011; 95% CI 1.002–1.020; p = 0.0137). Conclusions Baseline plasma sclerostin is an independent risk factor for all-cause mortality in patients after kidney transplantation.

scholarly journals High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients

2010 ◽  
Vol 23 (8) ◽  
pp. 805-812 ◽  
Author(s):  
Jan A. Krikken ◽  
Rutger M. Van Ree ◽  
Astrid Klooster ◽  
Marcus A. Seelen ◽  
Theo Borghuis ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Transplant ◽  
Graft Failure ◽  
Independent Risk Factor ◽  
High Plasma ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Hyperhomocyst(e)inemia as an independent risk factor for cardiovascular disease in renal transplant recipients.

1998 ◽  
Vol 65 (Supplement) ◽  
pp. 151
Author(s):  
Didier DUCLOUX ◽  
Christophe RUEDIN ◽  
Roger GIBEY ◽  
Jean-Michel REBIBOU ◽  
Catherine BRESSON-VAUTRIN ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Renal Transplant ◽  
Independent Risk Factor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Osteoprotegerin is an independent risk factor predicting death in stable renal transplant recipients

2021 ◽  
Author(s):  
Shufei Zeng ◽  
Ahmed A. Hasan ◽  
Chang Chu ◽  
Yingquan Xiong ◽  
Johann-Georg Hocher ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Transplant ◽  
Independent Risk Factor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Latent cytomegalovirus infection is an independent risk factor for late graft failure in renal transplant recipients

2011 ◽  
Vol 17 (11) ◽  
pp. CR609-CR617 ◽  
Author(s):  
Rutger M. van Ree ◽  
Aiko P.J. de Vries ◽  
Dorien M. Zelle ◽  
Laura V. de Vries ◽  
Leendert H. Oterdoom ◽  
...  
Keyword(s):  
Risk Factor ◽  
Renal Transplant ◽  
Graft Failure ◽  
Cytomegalovirus Infection ◽  
Independent Risk Factor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Hyperhomocysteinaemia: a significant risk factor for cardiovascular disease in renal transplant recipients

1994 ◽  
Vol 9 (8) ◽  
pp. 1103-1108 ◽  
Author(s):  
Z. A. Massy ◽  
B. Chadefaux-Vekemans ◽  
A. Chevalier ◽  
C. A. Bade ◽  
T. B. Drüeke ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Renal Transplant ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Acute kidney injury in renal transplant recipients undergoing cardiac surgery

2020 ◽  
Vol 36 (1) ◽  
pp. 185-196
Author(s):  
Gregory L Hundemer ◽  
Anand Srivastava ◽  
Kirolos A Jacob ◽  
Neeraja Krishnasamudram ◽  
Salman Ahmed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Risk Factor ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Trough Levels

Abstract Background Acute kidney injury (AKI) is a key risk factor for chronic kidney disease in the general population, but has not been investigated in detail among renal transplant recipients (RTRs). We investigated the incidence, severity and risk factors for AKI following cardiac surgery among RTRs compared with non-RTRs with otherwise similar clinical characteristics. Methods We conducted a retrospective cohort study of RTRs (n = 83) and non-RTRs (n = 83) who underwent cardiac surgery at two major academic medical centers. Non-RTRs were matched 1:1 to RTRs by age, preoperative (preop) estimated glomerular filtration rate and type of cardiac surgery. We defined AKI according to Kidney Disease: Improving Global Outcomes criteria. Results RTRs had a higher rate of AKI following cardiac surgery compared with non-RTRs [46% versus 28%; adjusted odds ratio 2.77 (95% confidence interval 1.36–5.64)]. Among RTRs, deceased donor (DD) versus living donor (LD) status, as well as higher versus lower preop calcineurin inhibitor (CNI) trough levels, were associated with higher rates of AKI (57% versus 33% among DD-RTRs versus LD-RTRs; P = 0.047; 73% versus 36% among RTRs with higher versus lower CNI trough levels, P = 0.02). The combination of both risk factors (DD status and higher CNI trough level) had an additive effect (88% AKI incidence among patients with both risk factors versus 25% incidence among RTRs with neither risk factor, P = 0.004). Conclusions RTRs have a higher risk of AKI following cardiac surgery compared with non-RTRs with otherwise similar characteristics. Among RTRs, DD-RTRs and those with higher preop CNI trough levels are at the highest risk.

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