Estimating total genic diversity in the house mouse

1978 ◽  
Vol 16 (3-4) ◽  
pp. 287-297 ◽  
Author(s):  
Francois Bonhomme ◽  
Robert K. Selander
Keyword(s):  
House Mouse ◽  
Genic Diversity ◽  
Total Genic Diversity

The mating system and genic diversity in Martínez spruce, an extremely rare endemic of México's Sierra Madre Oriental: an example of facultative selfing and survival in interglacial refugia

2000 ◽  
Vol 30 (7) ◽  
pp. 1156-1164 ◽  
Author(s):  
F Thomas Ledig ◽  
Basilio Bermejo-Velázquez ◽  
Paul D Hodgskiss ◽  
David R Johnson ◽  
Celestino Flores-López ◽  
...  
Keyword(s):  
Mating System ◽  
High Frequency ◽  
Expected Heterozygosity ◽  
Sierra Madre ◽  
Fixation Indices ◽  
Rare Endemic ◽  
Genic Diversity ◽  
Total Genic Diversity ◽  
Two Populations ◽  
Nei's Genetic Distance

Martínez spruce (Picea martínezii T.F. Patterson) is a conifer currently passing through a bottleneck, reduced to a few relict populations totaling less than 800 trees. We used isozyme markers to analyze the mating system and survey the level of genic diversity in two populations. The mating system was characterized by a high frequency of selfing. The multilocus outcrossing rates (tm) and 95% confidence intervals were only 0.399 (0.197 < tm < 0.601) for the smallest population and 0.589 (0.475 < tm < 0.703) or 0.685 (0.465 < tm < 0.905), depending on year, for the largest. These are among the lowest rates of outcrossing observed in conifers. The fixation indices for the two populations were -0.058 and 0.121, less than expected for such high levels of selfing. Expected heterozygosity, unbiased He, based on 22 loci in 13 enzyme systems, was 0.121 and 0.101 in the two populations. The proportion of the total genic diversity between populations, FST, was 2.4%. Nm, the number of migrants per generation, was about 1.00 or 10.17, depending on the method of estimation. The time since the two populations were isolated was estimated from Nei's genetic distance as only 150 to 15 000 years, which is consistent with a hypothesis of population collapse during late Pleistocene or Holocene warming. We discuss the implications for conservation.

Estimating total genic diversity: Problems with the method of Bonhomme and Selander

1980 ◽  
Vol 18 (3-4) ◽  
pp. 333-335
Author(s):  
Jon D. Goguen ◽  
Lin Chao
Keyword(s):  
Genic Diversity ◽  
Total Genic Diversity

Response to ?estimating total genic diversity: Problems with the method of Bonhomme and Selander? by Jon D. Goguen and Lin Chao

1980 ◽  
Vol 18 (3-4) ◽  
pp. 337-338
Author(s):  
Fran�ois Bonhomme
Keyword(s):  
Genic Diversity ◽  
Total Genic Diversity

Grayed Hair as an Index of Relative Effective X-Ray Dosage in the House Mouse

1930 ◽  
Vol 64 (691) ◽  
pp. 188-190 ◽  
Author(s):  
Clyde E. Keeler
Keyword(s):  
House Mouse ◽  
X Ray

Early Cold Exposure: Effects on Behavioral and Physiological Thermoregulation in the House Mouse, Mus musculus

1976 ◽  
Vol 49 (2) ◽  
pp. 191-199 ◽  
Author(s):  
G. Robert Lynch ◽  
Carol Becker Lynch ◽  
Marjory Dube ◽  
Cynthia Allen
Keyword(s):  
House Mouse ◽  
Cold Exposure ◽  
Mus Musculus

scholarly journals Patterns of DNA Variability at X-Linked Loci in Mus domesticus

Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1303-1316
Author(s):  
Michael W Nachman
Keyword(s):  
Drosophila Melanogaster ◽  
X Chromosome ◽  
House Mouse ◽  
Recombination Rate ◽  
Nucleotide Diversity ◽  
Mus Domesticus ◽  
Substantial Variation ◽  
Intraspecific Polymorphism ◽  
Recombination Rates ◽  
Interspecific Divergence

Introns of four X-linked genes (Hprt, Plp, Glra2, and Amg) were sequenced to provide an estimate of nucleotide diversity at nuclear genes within the house mouse and to test the neutral prediction that the ratio of intraspecific polymorphism to interspecific divergence is the same for different loci. Hprt and Plp lie in a region of the X chromosome that experiences relatively low recombination rates, while Glra2 and Amg lie near the telomere of the X chromosome, a region that experiences higher recombination rates. A total of 6022 bases were sequenced in each of 10 Mus domesticus and one M. caroli. Average nucleotide diversity (π) for introns within M. domesticus was quite low (π = 0.078%). However, there was substantial variation in the level of heterozygosity among loci. The two telomeric loci, Glra2 and Amg, had higher ratios of polymorphism to divergence than the two loci experiencing lower recombination rates. These results are consistent with the hypothesis that heterozygosity is reduced in regions with lower rates of recombination, although sampling of additional genes is needed to establish whether there is a general correlation between heterozygosity and recombination rate as in Drosophila melanogaster.

scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

Dynamics of non-specific esterase during fat resorption in the jejunum of the house mouse, Mus musculus

1982 ◽  
Vol 75 (3) ◽  
pp. 377-385 ◽  
Author(s):  
A. Böcking ◽  
O. v. Deimling
Keyword(s):  
House Mouse ◽  
Mus Musculus

scholarly journals A new linkage in the house mouse: Undulated and agouti

Heredity ◽  
1947 ◽  
Vol 1 (3) ◽  
pp. 367-372 ◽  
Author(s):  
T C Carter
Keyword(s):  
House Mouse
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