scholarly journals Insights into mammalian biology from the wild house mouse Mus musculus

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Megan Phifer-Rixey ◽  
Michael W Nachman
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Genetic Model ◽  
Inbred Strains ◽  
Mendelian Inheritance ◽  
Model Organisms ◽  
House Mice ◽  
Small Subset ◽  
Wild Mice ◽  
Wide Range

The house mouse, Mus musculus, was established in the early 1900s as one of the first genetic model organisms owing to its short generation time, comparatively large litters, ease of husbandry, and visible phenotypic variants. For these reasons and because they are mammals, house mice are well suited to serve as models for human phenotypes and disease. House mice in the wild consist of at least three distinct subspecies and harbor extensive genetic and phenotypic variation both within and between these subspecies. Wild mice have been used to study a wide range of biological processes, including immunity, cancer, male sterility, adaptive evolution, and non-Mendelian inheritance. Despite the extensive variation that exists among wild mice, classical laboratory strains are derived from a limited set of founders and thus contain only a small subset of this variation. Continued efforts to study wild house mice and to create new inbred strains from wild populations have the potential to strengthen house mice as a model system.

scholarly journals Whole-genome sequencing analysis reveals the population history of Mus musculus in Madagascar

2021 ◽  
Author(s):  
Kazumichi Fujiwara ◽  
Marie C Ranorosoa ◽  
Satoshi D Ohdachi ◽  
Satoru Arai ◽  
Yuki Sakuma ◽  
...  
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Population History ◽  
House Mice ◽  
Whole Genome ◽  
Sequencing Analysis ◽  
Mouse Population ◽  
Wide Range ◽  
History Of ◽  
Ancient Hybridization

AbstractIn Madagascar, the house mouse (Mus musculus) is thought to have colonized along with humans and is now one of the most successfully colonized rodents on the island. In this study, we determined the whole-genome sequences of the Madagascar house mouse captured from the wild. We examined the evolutionary history of its population regarding the mitochondrial and autosomal genomes. We confirmed that in the mitochondrial genomes of Madagascar house mice, a monophyletic clade forms a basal origin within the species. An analysis of autosomal genomic sequences indicates that the Madagascar house mouse population is genetically a member of M. m. castaneus (CAS). It also contains genetic elements of M. m. domesticus (DOM) resulting from ancient hybridization. The signature of a strong population bottleneck 1000–3000 years ago was observed in the mitochondrial and autosomal genomic data. We also show that the divergence of the Madagascar population from the CAS population occurred approximately 50,000–99,000 years ago. Madagascar house mice show strong genetic affinity to many CAS samples across a wide range of Indian Ocean coastal regions. However, our results suggest that they would not have originated directly from the Indonesian islands, where Austronesian-speaking people in Madagascar originated. Because the ancient hybridization signature with DOM did not appear in the Indonesian and other CAS samples, we propose that Madagascar house mice were not directly brought by Austronesian-speaking people but came from somewhere around the Middle East or South Asia soon after the colonization of initial farmers.

scholarly journals Haemoglobin variants in mice

1979 ◽  
Vol 13 (1) ◽  
pp. 11-13
Author(s):  
Homai P. Randelia ◽  
S. N. Naik
Keyword(s):  
Mus Musculus ◽  
Inbred Strains ◽  
House Mice ◽  
Wild Mice ◽  
Electrophoretic Technique ◽  
Starch Gel

Haemoglobin variants were studied in wild and laboratory house mice ( Mus musculus), including standard and new inbred strains, using starch-gel electrophoretic technique. Single (Hbbs) or diffuse (Hbbd) types of haemoglobin were found in all of them. The embryonic haemoglobin pattern was different from although similar to that of the adult in all the strains. The haemoglobins revealed monomorphism in the inbred strains, while polymorphism was observed in non-inbred laboratory and wild mice.

scholarly journals Pen and field trials of a new anticoagulant rodenticide flocoumafen against the house mouse (Mus musculus L.)

1985 ◽  
Vol 95 (3) ◽  
pp. 623-627 ◽  
Author(s):  
F. P. Rowe ◽  
A. Bradfield ◽  
T. Swinney
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Treatment Success ◽  
Field Trials ◽  
Mortality Data ◽  
House Mice ◽  
Anticoagulant Rodenticide ◽  
Free Living ◽  
Wild Mice ◽  
Farm Buildings

SUMMARYThe efficacy of flocoumafen, a novel anticoagulant rodentide, was evaluated in feeding tests on confined and free-living populations of house mice (Mus musculus L.). In four pen trials, family groups of laboratory-reared wild mice were conditioned to feeding on plain foods and then offered flocoumafen at 0.005% in pinhead oatmeal bait. All 68 mice, comprising juvenile and adult animals, died within 10 days.Ten field trials were carried out, using the same formulated poison bait, against mice infesting farm buildings. Mean treatment success, estimated from live-capture and mortality data, ranged between 87–1 and 100%.The performance of flocoumafen is compared with that of difenacoum, bromadiolone and brodifacoum used at the same concentration in oatmeal bait. Flocoumafen gave an equally effective but quicker kill of mice. It is concluded that flocoumafen is a promising new rodenticide for the control of M. musculus.

scholarly journals Host subspecific viral strains in European house mice: Murine cytomegalovirus in the Eastern (Mus musculus musculus) and Western house mouse (Mus musculus domesticus)

Virology ◽  
2018 ◽  
Vol 521 ◽  
pp. 92-98 ◽  
Author(s):  
Dagmar Čížková ◽  
Stuart J.E. Baird ◽  
Jana Těšíková ◽  
Sebastian Voigt ◽  
Ďureje Ľudovít ◽  
...  
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Murine Cytomegalovirus ◽  
House Mice ◽  
Mus Musculus Domesticus ◽  
Mus Musculus Musculus

scholarly journals Field trials of calciferol combined with warfarin against wild house-mice (Mus musculus L.)

1974 ◽  
Vol 73 (3) ◽  
pp. 353-360 ◽  
Author(s):  
F. P. Rowe ◽  
F. J. Smith ◽  
T. Swinney
Keyword(s):  
Vitamin D ◽  
House Mouse ◽  
Mus Musculus ◽  
Corn Oil ◽  
Field Trials ◽  
Post Treatment ◽  
House Mice ◽  
Effective Combination ◽  
Wild House Mice ◽  
Farm Buildings

SummaryA combination of calciferol (vitamin D2) and warfarin, each at 0·025% in medium oatmeal bait, failed to control six of seven house-mouse (Mus musculus L.) populations infesting urban and farm buildings. In three further treatments with both calciferol and warfarin at 0·05 % in dehusked canary seed bait plus 5% corn oil, mortality, estimated from the consumption of pre- and post-treatment census bait, ranged between 94·2 and 97·4%. Finally, among sixteen treatments done with calciferol at 0·1% and warfarin at 0·025% in various cereal baits, the best results (97·0–100%) were obtained in six treatments where the bait-base was whole canary seed; this was so whether the poison bait was applied directly or after a 3-day pre-baiting period. It is concluded that calciferol at 0·1 % plus warfarin at 0·025 % is an effective combination against house-mice, especially when used with whole canary seed. The role played by warfarin in the poison mixture needs to be investigated further.

scholarly journals The toxicity and acceptability of the sodium salt of pindone, an anti-coagulant rodenticide, to the house-mouse (Mus musculus L.)

1961 ◽  
Vol 59 (3) ◽  
pp. 335-341 ◽  
Author(s):  
F. P. Rowe
Keyword(s):  
House Mouse ◽  
Sodium Salt ◽  
Mus Musculus ◽  
House Mice ◽  
Wild House Mice ◽  
The Difference

1. A 0·005% solution of the sodium salt of pindone was found to kill wild house-mice (Mus musculus) in 4–6 days. Mice offered a choice between this solution and water drank more water, but the difference in consumption was not statistically significant.2. The addition of 1% sugar did not appreciably alter the palatability of a 0·005% solution, but a solution of the anti-coagulant containing 10% sugar was more readily accepted than water. This preference was maintained with solution 4 months old.

scholarly journals Field trials of the rodenticide 5-p-chlorophenyl silatrane against wild house mice (Mus musculus L.)

1974 ◽  
Vol 73 (1) ◽  
pp. 49-52 ◽  
Author(s):  
F. P. Rowe ◽  
T. Swinney ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Corn Oil ◽  
Treatment Success ◽  
Field Trials ◽  
Zinc Phosphide ◽  
House Mice ◽  
Before And After ◽  
Wild House Mice

SUMMARYThe performance of the rodenticide 5-p-chlorophenyl silatrane at 0.5% in a wholemeal flour/pinhead oatmeal/corn oil bait was compared with that of zinc phosphide at 3% in the same base in poison treatments carried out against urban infestations of the house mouse (Mus musculus L.). Each poison treatment was conducted for 1 day and after 3 days' pre-baiting. The success of the treatments was assessed from census baitings conducted before and after treatment. Treatment success varied considerably with both poisons used but in general 5-p-chlorophenyl silatrane proved to be at least as effective as zinc phosphide, a commonly used acute rodenticide for the control of mice.

scholarly journals Low diversity of t haplotypes in the eastern form of the house mouse, Mus musculus L.

Genetics ◽  
1991 ◽  
Vol 127 (1) ◽  
pp. 161-168
Author(s):  
A Ruvinsky ◽  
A Polyakov ◽  
A Agulnik ◽  
H Tichy ◽  
F Figueroa ◽  
...  
Keyword(s):  
Soviet Union ◽  
House Mouse ◽  
Mus Musculus ◽  
Complementation Test ◽  
Antigenic Determinants ◽  
Lethal Gene ◽  
Eastern Siberia ◽  
Wild Mice ◽  
Low Diversity ◽  
Lethal Genes

Abstract In previous studies, 13 different recessive embryonic lethal genes have been associated with t haplotypes in the wild mice of the species Mus domesticus. In this communication we have analyzed five populations of Mus musculus for the presence and identity of t haplotypes. The populations occupy geographically distant regions in the Soviet Union: Altai Mountains, western and eastern Siberia, Azerbaijan and Turkmenistan. No t haplotypes were found in mice from eastern Siberia. In the remaining four populations, t haplotypes occurred with frequencies ranging from 0.07 to 0.21. All the t haplotypes extracted from these populations and analyzed by the genetic complementation test were shown to carry the same lethal gene tcl-w73. In one population (that of western Siberia), another lethal gene (tcl-w5) was found to be present on the same chromosome as tcl-w73. This situation is in striking contrast to that found in the populations of the western form of the house mouse, M. domesticus. In the latter species, tcl-w73 has not been found at all and the different populations are characterized by the presence of several different lethal genes. The low diversity of t haplotypes in M. musculus is consistent with lower genetic variability of other traits and indicates a different origin and speciation mode compared to M. domesticus. Serological typing for H-2 antigenic determinants suggests that most, if not all, of the newly described t haplotypes might have arisen by recombination of tw73 from M. musculus with t haplotypes from M. domesticus either in the hybrid zone between the two species or in regions where the two species mixed accidentally.

scholarly journals Trials of the anticoagulant rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.)

1976 ◽  
Vol 77 (3) ◽  
pp. 427-431 ◽  
Author(s):  
F. P. Rowe ◽  
A. Bradfield
Keyword(s):  
House Mouse ◽  
Mus Musculus ◽  
Toxicity Tests ◽  
House Mice ◽  
Anticoagulant Rodenticide ◽  
Laboratory Findings ◽  
Anticoagulant Rodenticides ◽  
Choice Feeding ◽  
Better Than ◽  
Family Groups

SUMMARYThe efficacy of the newly developed anticoagulant rodenticide WBA 8119 was evaluated against the house mouse (Mus musculus L.) using individual and family groups of warfarin-resistant animals. WBA 8119 at 0·002 %, O % and 0.01 % in pinhead oatmeal bait gave complete kills of mice in ‘no-choice’ feeding tests carried out in cages and small pens. In replicated 21-day treatments on families of mice confined in larger pens and conditioned to feeding on plain foods, the overall mortalities obtained using the three formulated poison baits were 71/72, 62/63 and 57/57 respectively.The results of the WBA 8119 toxicity tests are considered in relation to previous findings on other anticoagulant rodenticides, particularly difenacoum. In equivalent tests, WBA 8119 performed better than difenacoum. The data thus support the laboratory findings that WBA 8119 is the most active anticoagulant so far tested for the control of warfarin-resistant house mice.

Studies on salmonellosis in the house mouse, Mus musculus

1979 ◽  
Vol 13 (1) ◽  
pp. 33-34 ◽  
Author(s):  
Ahmad Shimi ◽  
Massoud Keyhani ◽  
Khosrow Hedayati
Keyword(s):  
Salmonella Typhimurium ◽  
House Mouse ◽  
Mus Musculus ◽  
House Mice ◽  
Wild House Mice

Salmonellae were isolated from the faeces from 17 of 170 (10%) wild house mice. Salmonella typhimurium was isolated from 10, S. typhimurium, var. Copenhagen from 2, S. thompson from 1, and S. muenchen from 4. It was concluded that house mice could be a reservoir of infection and play an important role in human and animal salmonellosis.

Sign in / Sign up

Export Citation Format

Share Document