Histochemical and cytochemical studies of alkaline phosphatase activity in the synapses of rat brain

1979 ◽  
Vol 61 (2) ◽  
pp. 123-129 ◽  
Author(s):  
K. Sugimura ◽  
A. Mizutani
Keyword(s):  
Alkaline Phosphatase ◽  
Rat Brain ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity

Chlorpromazine and other psychoactive drug induced alterations of a membrane bound enzyme in rat brain

1994 ◽  
Vol 14 (3) ◽  
pp. 139-144
Author(s):  
Maitreyi Nag ◽  
Namita Nandi
Keyword(s):  
Alkaline Phosphatase ◽  
Rat Brain ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Drug Induced ◽  
Effective Inhibition ◽  
Membrane Bound ◽  
The Individual ◽  
Membrane Bound Enzymes ◽  
Combined Drugs

Psychoactive drugs like chlorpromazine (CPZ), imipramine, lithium and amphetamine in one way or another affect behaviour. The drug responses are presumably mediated by inducing a change in the activity of membrane bound enzymes. CPZ is very potent in inhibiting the alkaline phosphatase activity in rat brain. The combined effect of CPZ with other drugs shows that CPZ and imipramine together inhibit the enzyme activity significantly greater than the individual inhibition either by CPZ or by imipramine alone. Effective inhibition of the alkaline phosphatase activity with a single drug or combined drugs may lead to a change in neuronal permeability through glucocorticoids thereby affecting mood.

LEUCOCYTE METABOLISM IN PREGNANCY

1960 ◽  
Vol XXXV (IV) ◽  
pp. 575-584 ◽  
Author(s):  
C. Borel ◽  
J. Frei ◽  
A. Vannotti
Keyword(s):  
Alkaline Phosphatase ◽  
Oxygen Consumption ◽  
Pregnant Women ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Lactate Production ◽  
Glucose Consumption ◽  
In Pregnancy

ABSTRACT Enzymatic studies, on leucocytes of pregnant women, show an increase of the alkaline phosphatase activity and a decrease of the glucose consumption and lactate production, as well as of proteolysis. The oxygen consumption, with succinate as substrate, does not vary.

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