The role of the splanchnic circulation in the regulation of total intravascular volume during alpha adrenergic receptor stimulation

1986 ◽  
Vol 406 (4) ◽  
pp. 356-361 ◽  
Author(s):  
Leonard Bell ◽  
David L. Rutlen
Keyword(s):  
Adrenergic Receptor ◽  
Splanchnic Circulation ◽  
Intravascular Volume ◽  
Receptor Stimulation ◽  
Alpha Adrenergic Receptor

Abstract 395: Voluntary Exercise Enhances Cardiac Growth in Response to Chronic β-Adrenergic Receptor Stimulation

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Stephen W Luckey ◽  
Nathan McLaughlin ◽  
Sherilynn Soo
Keyword(s):  
Exercise Capacity ◽  
Adrenergic Receptor ◽  
Wheel Running ◽  
Voluntary Exercise ◽  
Published Data ◽  
Receptor Stimulation ◽  
Cardiac Growth ◽  
Heart Size ◽  
Underlying Mechanisms

Exercise training protects the heart against the adverse effects of cardiovascular disease. Recent studies have identified a number of cardiac adaptations including the activation of hypertrophic signaling pathways unique to exercise. However, the underlying mechanisms by which exercise confers cardioprotection are not entirely understood. This study aims to fill this gap by examining the role of voluntary exercise in the context of chronic β-adrenergic receptor stimulation. To do this, we developed a novel experimental model in which nine-week-old female and male CB6F1 hybrid mice were subjected to 5 weeks of voluntary wheel running (EX) or housed under sedentary conditions (SED). For the final two weeks, mice were administered either vehicle (VEH) or isoproterenol (ISO, 30mg/kg/day) via an osmotic pump. As expected, we found that ISO significantly increased heart size in sedentary females and males (SED+ISO) compared to sedentary mice receiving VEH (SED+VEH). Consistent with previously published data, exercise capacity was also greater in females compared to males with regards to running duration and distance regardless of the experimental group. While exercise capacity was not affected by the administration of VEH, mice receiving ISO (EX+ISO) exercised significantly less. Cardiac growth in EX+VEH mice was significantly increased in both females and males compared to their respective SED+VEH counterparts. Importantly, EX+ISO females and males have significantly larger hearts than their respective SED+ISO cohorts. Moreover, EX+ISO mice also exhibited greater increases in cardiac size as compared to their respective EX+VEH counterparts. Thus, we conclude that there appears to be an additive effect of voluntary exercise and ISO administration in both females and males in terms of cardiac growth. These preliminary data are in contrast to previously published data which found that controlled exercise programs reduced cardiac hypertrophy under conditions of chronic β-adrenergic receptor stimulation. We are currently investigating the processes that lead to the larger heart sizes in the EX+ISO mice and aim to better understand the underlying mechanisms of exercise-mediated cardioprotection.

ALTERATIONS OF FIBRINOLYSIS AND BLOOD COAGULATION INDUCED BY EXERCISE, AND THE ROLE OF BETA-ADRENERGIC-RECEPTOR STIMULATION

The Lancet ◽  
1968 ◽  
Vol 292 (7581) ◽  
pp. 1264-1266 ◽  
Author(s):  
RichardJ. Cohen ◽  
StephenE. Epstein ◽  
LawrenceS. Cohen ◽  
LewisH. Dennis
Keyword(s):  
Blood Coagulation ◽  
Adrenergic Receptor ◽  
Beta Adrenergic Receptor ◽  
Receptor Stimulation ◽  
Beta Adrenergic

Species differences in regulation of alpha-adrenergic receptor function

1989 ◽  
Vol 257 (5) ◽  
pp. R1110-R1116 ◽  
Author(s):  
Y. T. Shen ◽  
D. E. Vatner ◽  
H. E. Gagnon ◽  
S. F. Vatner
Keyword(s):  
Adrenergic Receptor ◽  
Maximum Rate ◽  
Species Differences ◽  
Mammalian Species ◽  
Left Ventricular ◽  
Receptor Density ◽  
Adrenergic Agonists ◽  
Receptor Stimulation ◽  
Alpha Adrenergic Receptor ◽  
Pressure Development

The effects of alpha-adrenergic receptor stimulation with norepinephrine and phenylephrine after beta-adrenergic and muscarinic receptor blockades were compared in conscious baboons, calves, dogs, and rats in which left ventricular (LV) pressure. LV maximum rate of pressure development (dP/dt), and heart rate were measured. Autonomic receptor density was examined in crude sarcolemmal preparations from the hearts. The major physiological differences were observed in rats, where alpha 1-adrenergic receptor stimulation resulted in the greatest (P less than 0.05) increases in LV dP/dt (29 +/- 2%) in response to phenylephrine, 5.0 micrograms/kg, in comparison with responses in dogs (12 +/- 4%), calves (3 +/- 3%), and baboons (1 +/- 2%). This was associated with the greatest (P less than 0.05) alpha 1-adrenergic receptor density in the rat heart (73 +/- 5 fmol/mg) compared with values in the baboon (6 +/- 1 fmol/mg), calf (21 +/- 3 fmol/mg), or dog (10 +/- 3 fmol/mg) myocardium. Thus there are major differences among mammalian species in alpha-adrenergic receptor density and physiological responsiveness to alpha-adrenergic agonists.

Effect of alpha adrenergic receptor stimulation on integrated systemic venous bed

1977 ◽  
Vol 370 (3) ◽  
pp. 241-246 ◽  
Author(s):  
E. R. M�ller-Ruchholtz ◽  
H. -M. L�sch ◽  
E. Grund ◽  
W. Lochner
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Stimulation ◽  
Alpha Adrenergic Receptor
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