Heat shock proteins and drug resistance

Suzanne A. W. Fuqua; Steffi Oesterreich; Susan G. Hilsenbeck; Daniel D. Von Hoff; John Eckardt; C. Kent Osborne

doi:10.1007/bf00666207

Heat shock proteins and drug resistance

Breast Cancer Research and Treatment ◽

10.1007/bf00666207 ◽

1994 ◽

Vol 32 (1) ◽

pp. 67-71 ◽

Cited By ~ 64

Author(s):

Suzanne A. W. Fuqua ◽

Steffi Oesterreich ◽

Susan G. Hilsenbeck ◽

Daniel D. Von Hoff ◽

John Eckardt ◽

...

Keyword(s):

Drug Resistance ◽

Heat Shock ◽

Heat Shock Proteins ◽

Shock Proteins

A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites

10.5772/intechopen.98852 ◽

2021 ◽

Author(s):

Xolani Henry Makhoba

Keyword(s):

Drug Resistance ◽

Heat Shock ◽

Heat Shock Proteins ◽

Human Life ◽

Cellular System ◽

Mosquito Vector ◽

Contributing Factors ◽

Temperature Changes ◽

Alternative Future ◽

Shock Proteins

Malaria remains a threat to human life worldwide with children under the age of 5 being the most vulnerable. Plasmodium falciparum, known as the causative agent of the deadliest malaria, survives both in the mosquito vector and human host. The sudden temperature change seems to not affect the parasite’s cellular system. Heat shock proteins and polyamines are the major house-keepers of the parasite’s cellular system to remain viable, despite the temperature changes that the parasite gets exposed to. While heat shock proteins protect newly synthesized proteins until they are properly folded polyamines are needed for cell differentiation, proliferation, and cell growth. In plants for example, polyamines have been reported to act as molecular chaperones when cells are exposed to unfavorable conditions that could be detrimental to cells. In this review, the role of heat shock proteins and polyamines in plasmodium parasite drug resistance and their role in parasite survival are discussed. The current drugs against malaria as well as the alternative future approach towards malarial drug development are reviewed.

Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

Gynecologic Oncology ◽

10.1016/j.ygyno.2009.10.078 ◽

2010 ◽

Vol 117 (2) ◽

pp. 177-182 ◽

Cited By ~ 54

Author(s):

Matteo Landriscina ◽

Maria Rosaria Amoroso ◽

Annamaria Piscazzi ◽

Franca Esposito

Keyword(s):

Ovarian Cancer ◽

Drug Resistance ◽

Heat Shock ◽

Cancer Therapy ◽

Heat Shock Proteins ◽

Cell Survival ◽

Novel Target ◽

Shock Proteins