scholarly journals A Double Line of Defense: Heat Shock Proteins and Polyamines Act as Contributing Factors to Drug Resistance of some Plasmodium Parasites

2021 ◽  
Author(s):  
Xolani Henry Makhoba
Keyword(s):  
Drug Resistance ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Human Life ◽  
Cellular System ◽  
Mosquito Vector ◽  
Contributing Factors ◽  
Temperature Changes ◽  
Alternative Future ◽  
Shock Proteins

Malaria remains a threat to human life worldwide with children under the age of 5 being the most vulnerable. Plasmodium falciparum, known as the causative agent of the deadliest malaria, survives both in the mosquito vector and human host. The sudden temperature change seems to not affect the parasite’s cellular system. Heat shock proteins and polyamines are the major house-keepers of the parasite’s cellular system to remain viable, despite the temperature changes that the parasite gets exposed to. While heat shock proteins protect newly synthesized proteins until they are properly folded polyamines are needed for cell differentiation, proliferation, and cell growth. In plants for example, polyamines have been reported to act as molecular chaperones when cells are exposed to unfavorable conditions that could be detrimental to cells. In this review, the role of heat shock proteins and polyamines in plasmodium parasite drug resistance and their role in parasite survival are discussed. The current drugs against malaria as well as the alternative future approach towards malarial drug development are reviewed.

scholarly journals Temperature shock tolerance and heat shock proteins in Arctic freshwater ostracod Candona rectangulata - preliminary results

2012 ◽  
Vol 33 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Barbara Wojtasik ◽  
Dorota Kuczyńska-Wiśnik
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Protein Profile ◽  
Model Organism ◽  
Arctic Water ◽  
Temperature Shock ◽  
Temperature Changes ◽  
Preliminary Results ◽  
Shock Proteins ◽  
First Time

Temperature shock tolerance and heat shock proteins in Arctic freshwater ostracod Candona rectangulata - preliminary results Candona rectangulata is an ostracod species common in cold (<15°C) shallow freshwater Arctic water bodies. This species is useful in palaeolimnological studies because only few known autecological data can be applied in reconstructions of palaeoclimate. Particular attention was paid to the temperature, which is the basic factor determining the geographic range of a species. In this study a wide tolerance of C. rectangulata to the temperature was demonstrated for the first time. Its high tolerance to the temperature changes seems to be based on induction of set of proteins belonging to the family of heat shock proteins. Using PAGE-SDS electrophoresis variation in the protein profile of non-model organism undergoing stress in the field (South Spitsbergen, near Stanisław Siedlecki Polish Polar Station) and in laboratory cultures was presented. These results could explain the eurythermic range of C. rectangulata and its good adaptation to the environmental conditions which normally do not exist in Arctic freshwater ponds.

Heat shock proteins and drug resistance

1994 ◽  
Vol 32 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Suzanne A. W. Fuqua ◽  
Steffi Oesterreich ◽  
Susan G. Hilsenbeck ◽  
Daniel D. Von Hoff ◽  
John Eckardt ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Shock Proteins

Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy

2010 ◽  
Vol 117 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Matteo Landriscina ◽  
Maria Rosaria Amoroso ◽  
Annamaria Piscazzi ◽  
Franca Esposito
Keyword(s):  
Ovarian Cancer ◽  
Drug Resistance ◽  
Heat Shock ◽  
Cancer Therapy ◽  
Heat Shock Proteins ◽  
Cell Survival ◽  
Novel Target ◽  
Shock Proteins

scholarly journals Biological Characterization of Plasmodium falciparum Mitochondrial Heat Shock Protein PfHsp70-3: Possible Involvement in Malaria Pathogenesis

2021 ◽  
Vol 47 (4) ◽  
pp. 1338-1351
Author(s):  
David O. Nyakundi ◽  
Aileen Boshoff
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Heat Shock Protein ◽  
Sub Saharan Africa ◽  
Parasite Development ◽  
Mosquito Vector ◽  
Heat Shocks ◽  
Febrile Episodes ◽  
Shock Proteins ◽  
Mitochondrial Heat Shock Protein

Malaria remains a global health burden accounting for many deaths and illnesses in sub-Saharan Africa notwithstanding many decades of research on the disease. P. falciparum, the causative agent of the most fatal form of malaria, expresses a repertoire of heat shock proteins (Hsp) that cushion the parasite against heat shocks as it shuttles between extreme temperatures in human and mosquito vector hosts. By so doing, such proteins promote parasite’s cytoprotection, survival and pathogenesis. Heat shock proteins are named according to their molecular weights and there are six P. falciparum Hsp70 (PfHsp70) found in various cell compartments with mitochondrial putative PfHsp70-3. Using indirect immunofluorescence, this study established mitochondrial localization of PfHsp70-3 though some more confirmatory studies would be needed in the future. PfHsp70-3 was found to be heat inducible and expressed during all stages of the intra-erythrocytic cycle of parasite development. This could be an indication of PfHsp70-3’s involvement in the infectivity process of P. falciparum by helping the parasite to resist heat shocks during malaria febrile episodes. Generally, the data obtained in this study will enhance the existing knowledge on the biology of P. falciparum mitochondrial heat shock protein functions and open possible avenues for targeting the specificity between PfHsp70-3 and its co-chaperones for drug development. Keywords: Malaria, P. falciparum, Heat shock proteins, PfHsp70-3, pathogenesis

Two Novel Agents Boost Heat Shock Proteins

2005 ◽  
Vol 36 (10) ◽  
pp. 14
Author(s):  
PATRICE WENDLING
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Novel Agents ◽  
Shock Proteins

Heat shock proteins in willow (Salix viminalis)

1990 ◽  
Vol 80 (2) ◽  
pp. 301-306
Author(s):  
Tiina Vahala ◽  
Tage Eriksson ◽  
Peter Engstrom
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Salix Viminalis ◽  
Shock Proteins
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