Cell degeneration and elimination in the imaginal wing disc, caused by the mutationsvestigial andUltravestigial ofDrosophila melanogaster

1983 ◽  
Vol 192 (5) ◽  
pp. 285-294 ◽  
Author(s):  
David O'Brochta ◽  
Peter J. Bryant
Keyword(s):  
Wing Disc ◽  
Cell Degeneration ◽  
Imaginal Wing Disc

Dpp signalling is a key effector of the wing-body wall subdivision of theDrosophilamesothorax

Development ◽  
2002 ◽  
Vol 129 (16) ◽  
pp. 3815-3823 ◽  
Author(s):  
Florencia Cavodeassi ◽  
Isabel Rodríguez ◽  
Juan Modolell
Keyword(s):  
Body Wall ◽  
Larval Instar ◽  
Proximal Part ◽  
Distal Region ◽  
Wing Disc ◽  
Signalling Pathway ◽  
Wing Development ◽  
C Cells ◽  
Imaginal Wing Disc ◽  
Anterior Posterior

During development, the imaginal wing disc of Drosophila is subdivided along the proximal-distal axis into different territories that will give rise to body wall (notum and mesothoracic pleura) and appendage (wing hinge and wing blade). Expression of the Iroquois complex (Iro-C) homeobox genes in the most proximal part of the disc defines the notum, since Iro-C– cells within this territory acquire the identity of the adjacent distal region, the wing hinge. Here we analyze how the expression of Iro-C is confined to the notum territory. Neither Wingless signalling, which is essential for wing development, nor Vein-dependent EGFR signalling, which is needed to activate Iro-C, appear to delimit Iro-C expression. We show that a main effector of this confinement is the TGFβ homolog Decapentaplegic (Dpp), a molecule known to pattern the disc along its anterior-posterior axis. At early second larval instar, the Dpp signalling pathway functions only in the wing and hinge territories, represses Iro-C and confines its expression to the notum territory. Later, Dpp becomes expressed in the most proximal part of the notum and turns off Iro-C in this region. This downregulation is associated with the subdivision of the notum into medial and lateral regions.

hrs gene and borders of compartments of imaginal wing disc in Drosophila melanogaster

2015 ◽  
Vol 51 (10) ◽  
pp. 1040-1043
Author(s):  
E. V. Marilovtseva ◽  
L. V. Omelyanchuk
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Disc ◽  
Imaginal Wing Disc

Connecting Hh, Dpp and EGF signalling in patterning of theDrosophilawing; the pivotal role ofcollier/knotin the AP organiser

Development ◽  
2002 ◽  
Vol 129 (18) ◽  
pp. 4261-4269 ◽  
Author(s):  
Michèle Crozatier ◽  
Bruno Glise ◽  
Alain Vincent
Keyword(s):  
Cell Proliferation ◽  
Central Region ◽  
Wing Disc ◽  
Signalling Pathways ◽  
Wild Type ◽  
Drosophila Wing ◽  
Egfr Ligand ◽  
Imaginal Wing Disc ◽  
Primary Determinant ◽  
Dose Dependent

Hedgehog (Hh) signalling from posterior (P) to anterior (A) cells is the primary determinant of AP polarity in the limb field in insects and vertebrates. Hh acts in part by inducing expression of Decapentaplegic (Dpp), but how Hh and Dpp together pattern the central region of the Drosophila wing remains largely unknown. We have re-examined the role played by Collier (Col), a dose-dependent Hh target activated in cells along the AP boundary, the AP organiser in the imaginal wing disc. We found that col mutant wings are smaller than wild type and lack L4 vein, in addition to missing the L3-L4 intervein and mis-positioning of the anterior L3 vein. We link these phenotypes to col requirement for the local upregulation of both emc and N, two genes involved in the control of cell proliferation, the EGFR ligand Vein and the intervein determination gene blistered. We further show that attenuation of Dpp signalling in the AP organiser is also col dependent and, in conjunction with Vein upregulation, required for formation of L4 vein. A model recapitulating the molecular interplay between the Hh, Dpp and EGF signalling pathways in the wing AP organiser is presented.

Transdetermination in imaginal wing disc fragments of Drosophila melanogaster

1983 ◽  
Vol 97 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Brooke S. Kirby ◽  
Peter J. Bryant ◽  
Howard A. Schneiderman
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Disc ◽  
Imaginal Wing Disc

Localized cell death in Drosophila imaginal wing disc epithelium caused by the mutation apterous-blot

1984 ◽  
Vol 104 (2) ◽  
pp. 489-496 ◽  
Author(s):  
Bonnie Joy Sedlak ◽  
René Manzo ◽  
Mary Stevens
Keyword(s):  
Cell Death ◽  
Wing Disc ◽  
Imaginal Wing Disc

scholarly journals Analysis of the Function of Apoptosis during Imaginal Wing Disc Regeneration in Drosophila melanogaster

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165554 ◽  
Author(s):  
Sandra Diaz-Garcia ◽  
Sara Ahmed ◽  
Antonio Baonza
Keyword(s):  
Drosophila Melanogaster ◽  
Wing Disc ◽  
Disc Regeneration ◽  
Imaginal Wing Disc
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