Comparison of-nitro versus-amino 4, 4?-substituents of disulfonic stilbenes as chloride channel blockers

1994 ◽  
Vol 140 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Charles J. Venglarik ◽  
Ashvani K. Singh ◽  
Robert J. Bridges
Keyword(s):  
Chloride Channel ◽  
Channel Blockers ◽  
Disulfonic Stilbenes

scholarly journals The actions of chloride channel blockers, barbiturates and a benzodiazepine on Caenorhabditis elegans glutamate- and ivermectin-gated chloride channel subunits expressed in Xenopus oocytes

2009 ◽  
Vol 9 (3-4) ◽  
pp. 175-184 ◽  
Author(s):  
Elizabeth Bush ◽  
Richard Foreman ◽  
Robert J. Walker ◽  
Lindy Holden-Dye
Keyword(s):  
Caenorhabditis Elegans ◽  
Chloride Channel ◽  
Xenopus Oocytes ◽  
Channel Blockers

scholarly journals Chloride Channel Blockers Inhibit Ca2+ Uptake by the Smooth Muscle Sarcoplasmic Reticulum

1998 ◽  
Vol 75 (4) ◽  
pp. 1759-1766 ◽  
Author(s):  
N.S. Pollock ◽  
M.E. Kargacin ◽  
G.J. Kargacin
Keyword(s):  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Chloride Channel ◽  
Channel Blockers

scholarly journals Chloride channel blockers decrease intracellular pH in cultured renal epithelial LLC-PK1 cells

1996 ◽  
Vol 118 (3) ◽  
pp. 443-444 ◽  
Author(s):  
Colin D.A. Brown ◽  
Adam J. Dudley
Keyword(s):  
Intracellular Ph ◽  
Chloride Channel ◽  
Channel Blockers

The Effects of Chloride Channel Blockers on Platelet Cytoplasmic Free Calcium Concentration and Platelet Aggregation.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3879-3879
Author(s):  
Songmei Yin ◽  
Xiaolin Chen ◽  
Danian Nie ◽  
Shuangfeng Xie ◽  
Liping Ma ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Chloride Channel ◽  
Calcium Concentration ◽  
Disulfonic Acid ◽  
Free Calcium ◽  
Channel Blockers ◽  
Free Calcium Concentration ◽  
Cytoplasmic Free Calcium

Abstract Objective To explore the effects of chloride channels on the regulations of platelet cytoplasmic free calcium concentration ([Ca2+]i) and platelet aggregation (PAG). Methods Platelet were separated freshly and then activated by thrombin; The chloride channel blockers 4,4′-diisothiocyano-2, 2′-disulfonic acid stilbene (DIDS) or niflumic acid (NFA), and calcium channel blockers 1-{β-[3-(4-methoxyphenyl)propoxy]- 4-methoxyphenethyl}- 1H - imidazole hydrochloride (SK&F96365) or Nifedipine were added to react with the activated platelets. The effects of each agent on platelet [Ca2+]i and PAG were detected. The combine effects and the interactions among chloride channel blockers (DIDS, NFA) and calcium channel blockers (SK&F96365, Nifedipine) were also investigated. Results Both DIDS and NFA [the concentration were12.5, 25, 50, 100 and 200μmol•L−1 respectively] could inhibit the PAG induced by thrombin (1U/ml) and the effect was dose-dependent. Compared with the control, they had no significant effects on resting [Ca2+]i. Compare with the control group, DIDS (100μmol•L−1), SK&F96365 (100μmol•L−1) and Nifedipine (100μmol•L−1) could significantly reduce the PAG, Ca2+ release and Ca2+ influx activated by thrombin in platelet (P<0.05). DIDS (100μmol•L−1) and SK&F96365 (100μmol•L−1) could enhance each other’s effect on reducing the PAG, Ca2+ release and Ca2+ influx (P<0.05). DIDS (100μmol•L−1) and Nifedipine (100μmol•L−1) could enhance each other’s effect on reducing Ca2+ release (P<0.05). NFA (100μmol•L−1) and SK&F96365 (100μmol•L−1) could weaken each other’s effect on Ca2+ release (P<0.05). NFA (100μmol•L−1) and Nifedipine (100μmol•L−1) could weaken each other’s effect on PAG, Ca2+ release and Ca2+ influx activated by thrombin in platelet (P<0.05). Conclusion The chloride channel blockers DIDS and NFA have no effect on the resting [Ca2+]i and the leak calcium influx of platelet. DIDS can inhibit the Ca2+ release, Ca2+ influx and PAG of platelet induced by thrombin, while NFA can only inhibit the Ca2+ release of platelet induced by thrombin. There are interactions between chloride channel blockers and calcium channel blockers in resting [Ca2+]i and PAG of platelet. The opening of chloride channel can influence the cellular calcium movement of platelet.

scholarly journals THE EFFECT OF CALCIUM AND CHLORIDE CHANNEL BLOCKERS ON THE MOVEMENT OF ANTIBODIES AND ALBUMIN IN THE RAT INTESTINE

1989 ◽  
Vol 26 (3) ◽  
pp. 268-268
Author(s):  
S Freier ◽  
M E Ran ◽  
J Faber
Keyword(s):  
Chloride Channel ◽  
Channel Blockers ◽  
Rat Intestine

scholarly journals Effects of chloride ion substitutes and chloride channel blockers on the transient outward current in rat ventricular myocytes

1996 ◽  
Vol 1273 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Thierry Lefevre ◽  
Isabel A. Lefevre ◽  
Alain Coulombe ◽  
Edouard Coraboeuf
Keyword(s):  
Chloride Channel ◽  
Ventricular Myocytes ◽  
Outward Current ◽  
Chloride Ion ◽  
Transient Outward Current ◽  
Channel Blockers ◽  
Rat Ventricular Myocytes

scholarly journals A Novel Chloride Channel Localizes toCaenorhabditis elegansSpermatids and Chloride Channel Blockers Induce Spermatid Differentiation

1996 ◽  
Vol 176 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Khaled Machaca ◽  
Louis J. DeFelice ◽  
Steven W. L'Hernault
Keyword(s):  
Chloride Channel ◽  
Channel Blockers

scholarly journals Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle

2013 ◽  
Vol 49 (0) ◽  
pp. 112-124 ◽  
Author(s):  
Peter D. Yim ◽  
George Gallos ◽  
Jose F. Perez-Zoghbi ◽  
Jacquelyn Trice ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Chloride Channel ◽  
Channel Blockers

Characterization of human sweat duct chloride conductance by chloride channel blockers

1987 ◽  
Vol 408 (5) ◽  
pp. 511-514 ◽  
Author(s):  
J. Bijman ◽  
H. C. Englert ◽  
H. J. Lang ◽  
R. Greger ◽  
E. Fr�mter
Keyword(s):  
Chloride Channel ◽  
Chloride Conductance ◽  
Channel Blockers ◽  
Sweat Duct ◽  
Human Sweat ◽  
Human Sweat Duct
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