Role of RNA and protein synthesis in memory formation

1979 ◽  
Vol 4 (3) ◽  
pp. 297-312 ◽  
Author(s):  
Thomas C. Rainbow
1986 ◽  
Vol 106 (2) ◽  
pp. 278 ◽  
Author(s):  
Ryuji Higashikubo ◽  
Nazan Uygur ◽  
Joseph L. Roti Roti

2008 ◽  
Vol 2008 ◽  
pp. 1-8 ◽  
Author(s):  
Lia R. M. Bevilaqua ◽  
Janine I. Rossato ◽  
Juliana S. Bonini ◽  
Jociane C. Myskiw ◽  
Julia R. Clarke ◽  
...  

The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It plays a key role in memory formation, retrieval, and extinction, as part of circuits that include the hippocampus, the amygdaloid nucleus, and several regions of the neocortex, in particular of the prefrontal cortex. Lesions or biochemical impairments of the entorhinal cortex hinder extinction. Microinfusion experiments have shown that glutamate NMDA receptors, calcium and calmodulin-dependent protein kinase II, and protein synthesis in the entorhinal cortex are involved in and required for extinction. Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex.


2016 ◽  
Vol 1 (1) ◽  
Author(s):  
David Levitan ◽  
Shunit Gal-Ben-Ari ◽  
Christopher Heise ◽  
Tali Rosenberg ◽  
Alina Elkobi ◽  
...  

1980 ◽  
Vol 21 (2) ◽  
pp. 345-350 ◽  
Author(s):  
Rameshwar Sharma ◽  
Sudhir K. Sopory ◽  
Sipra Guha-Mukherjee

Virology ◽  
1982 ◽  
Vol 122 (2) ◽  
pp. 381-391 ◽  
Author(s):  
Arlene H. Sharpe ◽  
Bernard N. Fields

On interferon treatment cells develop an antiviral state. This requires time and RNA and protein synthesis. At least six polypeptides and two enzymes have been reported to be synthesized in increased amounts in response to interferon and a multiplicity of effects have been attributed to it. Interferon has been reported to inhibit virus growth at the level of the uncoating of the virus, virus RNA and protein synthesis and virus maturation. This has led to the acceptance of a multisite model for interferon action. The evidence for this and for the role of two known interferon-mediated enzymes, the 2-5A synthetase and protein kinase, are reviewed.


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