Effect of three organophosphates on respiration in rat brain and liver tissue

The relative incorporation of a number of C14-labelled precursors into the phosphatides of surviving rat brain and liver slices was examined. In addition, the distribution of radioactivity within the individual phosphoglycerides was determined for each precursor. Acetate was the only precursor that contributed considerable radioactivity to the fatty acid portion of the phosphatide molecule. The other precursors donated their radioactivity to the non-fatty acid portion of the glycerophosphatide molecule, both in brain and liver tissue. In brain it was found that ethanolamine was the most effective precursor, followed by serine, choline, glycerol, acetate, and glycine. In liver the order was acetate, glycerol, serine, choline, and glycine. Aerobic conditions and an adequate carbohydrate metabolism were essential for optimum incorporation of the precursors into the phosphatides of brain slices.

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THE FORMATION OF GLYCEROPHOSPHATIDES FROM C14-LABELLED PRECURSORS IN RAT BRAIN SLICES

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y58-132 ◽

1958 ◽

Vol 36 (1) ◽

pp. 1211-1220 ◽

Cited By ~ 4

Author(s):

E. T. Pritchard

Keyword(s):

Fatty Acid ◽

Rat Brain ◽

Carbohydrate Metabolism ◽

Liver Tissue ◽

Brain Slices ◽

The Other ◽

Aerobic Conditions ◽

Liver Slices ◽

Rat Brain And Liver ◽

The Individual

The relative incorporation of a number of C14-labelled precursors into the phosphatides of surviving rat brain and liver slices was examined. In addition, the distribution of radioactivity within the individual phosphoglycerides was determined for each precursor. Acetate was the only precursor that contributed considerable radioactivity to the fatty acid portion of the phosphatide molecule. The other precursors donated their radioactivity to the non-fatty acid portion of the glycerophosphatide molecule, both in brain and liver tissue. In brain it was found that ethanolamine was the most effective precursor, followed by serine, choline, glycerol, acetate, and glycine. In liver the order was acetate, glycerol, serine, choline, and glycine. Aerobic conditions and an adequate carbohydrate metabolism were essential for optimum incorporation of the precursors into the phosphatides of brain slices.

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Quantitative microdialysis for the in vivo measurement of carbamazepine, oxcarbazepine and their major metabolites in rat brain- and liver tissue and in blood using the internal standard technique

European Journal of Pharmaceutical Sciences ◽

10.1016/0928-0987(95)00015-6 ◽

1995 ◽

Vol 3 (5) ◽

pp. 273-280 ◽

Cited By ~ 6

Author(s):

K. Van Belle ◽

S. Sarre ◽

G. Ebinger ◽

Y. Michotte

Keyword(s):

Rat Brain ◽

Liver Tissue ◽

Internal Standard ◽

Standard Technique ◽

In Vivo Measurement ◽

Rat Brain And Liver

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Phospholipids of subcellular fractions of rat brain and liver tissue in hypoxic hypoxia

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00804293 ◽

1984 ◽

Vol 98 (3) ◽

pp. 1190-1192

Author(s):

S. V. Gasteva ◽

T. E. Raize ◽

L. M. Sharagina

Keyword(s):

Rat Brain ◽

Liver Tissue ◽

Subcellular Fractions ◽

Hypoxic Hypoxia ◽

Rat Brain And Liver

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In vitro and in vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain

Bioscience Reports ◽

10.1007/bf01116753 ◽

1987 ◽

Vol 7 (10) ◽

pp. 801-803 ◽

Cited By ~ 3

Author(s):

Maitreyi Nag ◽

Namita Nandi

Keyword(s):

Monoamine Oxidase ◽

Rat Brain ◽

Oxidase Activity ◽

Brain Mitochondria ◽

Significant Inhibition ◽

Organophosphate Pesticides ◽

Monoamine Oxidase Activity ◽

Mao Activity

The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. These pesticides cause significant inhibition of MAO activity in vitro but have negligible effects on its activity in vivo.

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