Quantitative microdialysis for the in vivo measurement of carbamazepine, oxcarbazepine and their major metabolites in rat brain- and liver tissue and in blood using the internal standard technique

1995 ◽  
Vol 3 (5) ◽  
pp. 273-280 ◽  
Author(s):  
K. Van Belle ◽  
S. Sarre ◽  
G. Ebinger ◽  
Y. Michotte
1958 ◽  
Vol 36 (11) ◽  
pp. 1211-1220 ◽  
Author(s):  
E. T. Pritchard

The relative incorporation of a number of C14-labelled precursors into the phosphatides of surviving rat brain and liver slices was examined. In addition, the distribution of radioactivity within the individual phosphoglycerides was determined for each precursor. Acetate was the only precursor that contributed considerable radioactivity to the fatty acid portion of the phosphatide molecule. The other precursors donated their radioactivity to the non-fatty acid portion of the glycerophosphatide molecule, both in brain and liver tissue. In brain it was found that ethanolamine was the most effective precursor, followed by serine, choline, glycerol, acetate, and glycine. In liver the order was acetate, glycerol, serine, choline, and glycine. Aerobic conditions and an adequate carbohydrate metabolism were essential for optimum incorporation of the precursors into the phosphatides of brain slices.


1958 ◽  
Vol 36 (1) ◽  
pp. 1211-1220 ◽  
Author(s):  
E. T. Pritchard

The relative incorporation of a number of C14-labelled precursors into the phosphatides of surviving rat brain and liver slices was examined. In addition, the distribution of radioactivity within the individual phosphoglycerides was determined for each precursor. Acetate was the only precursor that contributed considerable radioactivity to the fatty acid portion of the phosphatide molecule. The other precursors donated their radioactivity to the non-fatty acid portion of the glycerophosphatide molecule, both in brain and liver tissue. In brain it was found that ethanolamine was the most effective precursor, followed by serine, choline, glycerol, acetate, and glycine. In liver the order was acetate, glycerol, serine, choline, and glycine. Aerobic conditions and an adequate carbohydrate metabolism were essential for optimum incorporation of the precursors into the phosphatides of brain slices.


Talanta ◽  
1994 ◽  
Vol 41 (6) ◽  
pp. 865-874 ◽  
Author(s):  
Kirk T. Kawagoe ◽  
R.Mark Wightman

Neuroscience ◽  
1987 ◽  
Vol 22 (2) ◽  
pp. 593-599 ◽  
Author(s):  
C. Redies ◽  
H. Matsuda ◽  
M. Diksic ◽  
E. Meyer ◽  
Y.L. Yamamoto

1991 ◽  
Vol 11 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Maitreyi Nag ◽  
Namita Nandi

The effects of three organophosphate pesticides, i.e. monocrotophos, dichlorvos, and phosphamidon on respiration in rat brain and liver tissue slices have been studied. Among these pesticides dichlorvos causes significant inhibition of respiration both in brain and liver.


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