Pro-opiocortin: The mutiple adrenal hormone precursor

1984 ◽  
Vol 4 (6) ◽  
pp. 467-482 ◽  
Author(s):  
P. J. Lowry
Keyword(s):  
Pituitary Gland ◽  
Biological Significance ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Adrenal Hormone ◽  
Response To Stress

Corticotropin (ACTH) is biosynthesized in the human pituitary gland as a long polypeptide precursor (pro-opiocortin) of some 240 residues. When ACTH is secreted in response to stress, the peptides derived from the rest or this precursor, pro-γ-melanotropin (γ-MSH) and β-1ipotropin (β-LPH), are also secreted (Fig. 1). This article will describe the search for a biological significance for this phenomenon.

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

Isolation of five active thyrotropin components from human pituitary gland

1975 ◽  
Vol 379 (1) ◽  
pp. 247-261 ◽  
Author(s):  
Paul Roos ◽  
D.V. Dervartanian ◽  
Gunilla Jacobson ◽  
Leif Wide
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland

The Presence, Characterisation and Synthesis of Neuromedin B in the Human Pituitary Gland

1992 ◽  
Vol 56 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Solange C. Hearn ◽  
Philip M. Jones ◽  
Mohammad A. Ghatei ◽  
Johanna Byrne ◽  
Sarah F. Hill ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Neuromedin B

Corticotropin-Releasing Factor Receptors in Human Pituitary Gland: Autoradiographic Localization

1985 ◽  
Vol 40 (5) ◽  
pp. 419-422 ◽  
Author(s):  
Errol B. De Souza ◽  
Marilyn H. Perrin ◽  
Peter J. Whitehouse ◽  
Jean Rivier ◽  
Wylie Vale ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Corticotropin Releasing Factor ◽  
Human Pituitary ◽  
Human Pituitary Gland

Aging and the Human Pituitary Gland

1993 ◽  
Vol 68 (10) ◽  
pp. 971-977 ◽  
Author(s):  
TOSHIAKI SANO ◽  
KALMAN T. KOVACS ◽  
BERND W. SCHEITHAUER ◽  
WILLIAM F. YOUNG
Keyword(s):  
Pituitary Gland ◽  
Human Pituitary ◽  
Human Pituitary Gland
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