Deficiency of erythrocyte C3b receptor (CR1) in AIDS and AIDS-related syndromes
The expression of C3b receptors (CR1) on erythrocytes of gay men at various levels of risk for AIDS was studied. Fourty-nine heterosexual male controls had a mean (X) ± standard deviation of 516 ± 136 CR1 per erythrocyte (CR1-3); 17 asymptomatic gay men had X = 423 ± 156, 16 gay men with one AIDS-related complex (ARC) symptom or sign had X = 342 ± 154, 9 patients with ARC had X = 252 ± 76, and 14 gay men with AIDS had X = 173 ± 76 CR1-E. The patients with ARC and AIDS had a highly significant decrease in CR1-E when compared with normal individuals (p = <0.001) and studies of families of 4 AIDS patients suggest that this defect is acquired.
1990 ◽
Vol 14
(6)
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pp. 605-609
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1988 ◽
Vol 62
(6)
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pp. 2026-2032
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1987 ◽
Vol 17
(2)
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pp. 210-220
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1988 ◽
Vol 158
(6)
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pp. 1396-1397
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1993 ◽
Vol 94
(2)
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pp. 169-174
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1988 ◽
Vol 47
(3)
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pp. 253-261
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1988 ◽
Vol 34
(2)
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pp. 153-154
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