Identification and characterization of the binding properties of steroid hormone receptors in the nuclear fraction of adenomas of the human prostate gland

1982 ◽  
Vol 12 (6) ◽  
pp. 484-488
Author(s):  
Ts. I. Gerasimova ◽  
A. N. Smirnov ◽  
A. F. Bunyatyan
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Prostate Gland ◽  
Steroid Hormone Receptors ◽  
Human Prostate ◽  
Nuclear Fraction ◽  
Binding Properties ◽  
Identification And Characterization

Distribution and characterization of steroid hormone receptors in human thyroid tissue

1986 ◽  
Vol 10 (5) ◽  
pp. 737-743 ◽  
Author(s):  
Prabir K. Chaudhuri ◽  
Nili Patel ◽  
Leslye Sandberg ◽  
Richard A. Prinz
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Thyroid Tissue ◽  
Steroid Hormone Receptors ◽  
Human Thyroid ◽  
Human Thyroid Tissue

PD23-05 DUTASTERIDE ACTION ON STEROID HORMONE RECEPTORS IN NORMAL HUMAN PROSTATE TISSUE

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
João C.C. Alonso ◽  
Patrick V. Garcia ◽  
Leonardo O. Reis ◽  
Ubirajara Ferreira ◽  
Wagner E. Matheus ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Prostate Tissue ◽  
Human Prostate ◽  
Human Prostate Tissue ◽  
Normal Human

Prognostic significance of steroid hormone receptors and histopathological characterization of human breast cancer

1987 ◽  
Vol 113 (3) ◽  
pp. 285-290 ◽  
Author(s):  
A. Reiner ◽  
R. Kolb ◽  
G. Reiner ◽  
R. Jakesz ◽  
M. Schemper ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Prognostic Significance ◽  
Steroid Hormone Receptors ◽  
Human Breast

Characterization of steroid hormone receptors with ion-exchange fast protein liquid chromatography

1985 ◽  
Vol 22 (1) ◽  
pp. 85-90 ◽  
Author(s):  
A.O. Brinkmann ◽  
J.Bolt-de Vries ◽  
W. de Boer ◽  
L.M. Lindh ◽  
E. Mulder ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Ion Exchange ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Fast Protein Liquid Chromatography ◽  
Steroid Hormone Receptors

Characterization of an incipient granulosa cell tumour in a Holstein cow: Steroid hormone receptors and coregulators expression

2021 ◽  
Author(s):  
Eduardo M. Belotti ◽  
Sofía C. Sacco ◽  
Antonela F. Stassi ◽  
Ulises S. Notaro ◽  
Emmanuel Angeli ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Cell Tumour ◽  
Granulosa Cell Tumour ◽  
Holstein Cow

The androgen receptor DNA-binding domain determines androgen selectivity of transcriptional response

2006 ◽  
Vol 34 (6) ◽  
pp. 1089-1094 ◽  
Author(s):  
G. Verrijdt ◽  
T. Tanner ◽  
U. Moehren ◽  
L. Callewaert ◽  
A. Haelens ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Dna Binding ◽  
Cellular Response ◽  
Hormone Receptors ◽  
Target Genes ◽  
Steroid Hormone ◽  
Prostate Gland ◽  
Steroid Hormone Receptors ◽  
Binding Motif

The AR (androgen receptor) is a hormone-dependent transcription factor that translates circulating androgen hormone levels into a physiological cellular response by directly regulating the expression of its target genes. It is the key molecule in e.g. the development and maintenance of the male sexual characteristics, spermatocyte production and prostate gland development and growth. It is also a major factor in the onset and maintenance of prostate cancer and a first target for pharmaceutical action against the further proliferation of prostate cancer cells. The AR is a member of the steroid hormone receptors, a group of steroid-inducible transcription factors sharing an identical consensus DNA-binding motif. The problem of how specificity in gene activation is achieved among the different members of this nuclear receptor subfamily is still unclear. In this report, we describe our investigations on how the AR can specifically activate its target genes, while the other steroid hormone receptors do not, despite having the same consensus monomeric DNA-binding motif. In this respect, we describe how the AR interacts with a newly identified class of steroid-response elements to which only the AR and not, for example, the glucocorticoid receptor can bind.

Abstract C56: Characterization of PinX1 as a coregulator of steroid hormone receptors

2011 ◽  
Author(s):  
Yamilet Noriega ◽  
Miguel Rivas ◽  
Elizabeth Langley
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors

scholarly journals EFFECTS OF EXOGENOUS LACTOFERRIN ON PHENOTYPIC PROFILE AND INVASIVENESS OF HUMAN PROSTATE CANCER CELLS (DU-145 AND LNCaP) IN VITRO

2018 ◽  
Vol 40 (3) ◽  
pp. 184-189 ◽  
Author(s):  
T V Zadvornyi ◽  
N Yu Lukianova ◽  
T V Borikun ◽  
V F Chekhun
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Ki 67 ◽  
Phenotypic Profile

Aim: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro. Materials and Methods: Human PC cell lines (LNCaP, DU-145) were cultured with an exogenous LF at a dose corresponding to IC30. The expression levels of steroid hormone receptors (androgen receptor, estrogen receptor, progesterone receptor), Her2/neu, Ki-67, E- and N-cadherin, were monitored by immunohistochemical analysis. The levels of miRNAs were assessed using q-PCR. The invasive activity of the cells was examined in a standard invasion test. Results: Exogenous LF reduced expression of steroid hormone receptors (ERα and PR) and Ki-67 in both PC cell lines. The expression of E-cadherin increased significantly in LF-treated DU-145 cells. Also, we established the decrease in invasive activity upon LF treatment by 40% and 30% in DU-145 and LNCaP cells, respectively. In DU-145 cells, incubation with exogenous LF resulted in an increase in the expression of oncosuppressive (miR-133a and miR-200b) miRNAs. Conclusions: Exogenous LF causes the changes in phenotypic characteristics of PC cells and levels of oncogenic and oncosuppressive miRNAs involved in the regulation of key cellular processes.

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