Level of glucocorticoid hormones in early postnatal ontogenesis and circadian rhythms of endocrine-metabolic functions in adult rats

1989 ◽  
Vol 19 (3) ◽  
pp. 216-219
Author(s):  
�. M. Kazin ◽  
A. M. Reshenin ◽  
S. B. Lur'e
Keyword(s):  
Circadian Rhythms ◽  
Postnatal Ontogenesis ◽  
Glucocorticoid Hormones ◽  
Adult Rats ◽  
Early Postnatal Ontogenesis ◽  
Metabolic Functions

The role of social isolation in critical periods of early postnatal ontogenesis in the formation of epileptic activity of the brain and learning ability in adulthood

2020 ◽  
Author(s):  
A.YU. SHishelova ◽  
K.S. Smirnov
Keyword(s):  
Social Isolation ◽  
Positive Reinforcement ◽  
Active Avoidance ◽  
Epileptic Activity ◽  
Absence Epilepsy ◽  
Learning Ability ◽  
Postnatal Ontogenesis ◽  
Critical Periods ◽  
Adult Rats ◽  
Early Postnatal Ontogenesis

The effect of complete social isolation in the critical periods of early postnatal ontogenesis on the learning and epileptic activity in Wag/Rij rats with a genetic predisposition to the absence epilepsy was studied. The different learning tasks with positive reinforcement (the Intellicage test) and punishment (the two-way active avoidance in the “shuttle box”) were used. It was found that a 3-hour daily social isolation of rat pups from the mother and siblings in early postnatal ontogenesis changes the learning ability and its connection with epileptic activity in adulthood depending on the period of isolation. The isolation from 2th to 8th postnatal day led to a decrease of epileptic activity and improved the learning with positive reinforcement in adult rats. The isolation from 9th to 15th postnatal day improved the learning a conditioned avoidance response with punishment and induced the interrelations between epileptic activity and the active avoidance learning. The isolation from 16th to 22th postnatal – 14 – Global science. Development and novelty day led to an improvement of positive reward-related learning and formation of the significant interactions between epileptic activity and the learning with positive and negative reinforcement.

Effect of Prenatal Hypoxia on Activity of the Soluble Forms of Cholinesterases in Rat Brain Structures during Early Postnatal Ontogenesis

2020 ◽  
Vol 56 (6) ◽  
pp. 531-540
Author(s):  
A. Yu. Morozova ◽  
A. V. Arutyunyan ◽  
P. Yu. Morozova ◽  
L. S. Kozina ◽  
I. A. Zhuravin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Structures ◽  
Prenatal Hypoxia ◽  
Postnatal Ontogenesis ◽  
Early Postnatal Ontogenesis

scholarly journals Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis

2019 ◽  
Vol 243 (3) ◽  
pp. R29-R46 ◽  
Author(s):  
Cátia F Gonçalves ◽  
Qing-Jun Meng
Keyword(s):  
Rheumatoid Arthritis ◽  
Circadian Rhythms ◽  
Circadian System ◽  
Tissue Homeostasis ◽  
Circadian Clocks ◽  
Clock System ◽  
Metabolic Functions ◽  
Biochemical Mechanisms ◽  
Skeletal Disorders ◽  
Bone Physiology

The circadian system in mammals is responsible for the temporal coordination of multiple physiological and behavioural processes that are necessary for homeostasis. In the skeleton, it has long been known that metabolic functions of chondrocytes, osteoblasts and osteoclasts exhibit intrinsic circadian rhythms. In addition, results from animal models reveal a close connection between the disruption of circadian rhythms and skeletal disorders such as rheumatoid arthritis, osteoarthritis and osteoporosis. In this review, we summarise the latest insights into the genetic and biochemical mechanisms linking cartilage and bone physiology to the circadian clock system. We also discuss how this knowledge can be utilised to improve human health.

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