Role of feedback in the dynamics of functional asymmetry in the cerebral hemispheres in humans

1988 ◽  
Vol 18 (2) ◽  
pp. 147-154 ◽  
Author(s):  
�. A. Kostandov
Keyword(s):  
Functional Asymmetry ◽  
Cerebral Hemispheres

Role of functional asymmetry of the cerebral hemispheres in organization of an instrumental food conditioned reflex in cats

1982 ◽  
Vol 12 (3) ◽  
pp. 249-253
Author(s):  
A. B. Kogan ◽  
G. A. Kuraev ◽  
G. �. Reps
Keyword(s):  
Conditioned Reflex ◽  
Functional Asymmetry ◽  
Cerebral Hemispheres

The Differential Role of the Cerebral Hemispheres in the Retrieval of the Semantic Features of Ambiguous Words

1999 ◽  
Author(s):  
Heather Humphrey ◽  
Ruth Ann Atchley ◽  
Michael Wilson
Keyword(s):  
Cerebral Hemispheres ◽  
Semantic Features ◽  
Ambiguous Words

scholarly journals The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes.

1996 ◽  
Vol 93 (1) ◽  
pp. 231-235 ◽  
Author(s):  
S. Y. Lai ◽  
W. Xu ◽  
S. L. Gaffen ◽  
K. D. Liu ◽  
G. D. Longmore ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Functional Asymmetry ◽  
Cytokine Receptor ◽  
Receptor Complexes ◽  
C Subunit ◽  
The Common

Central nervous system control of cardiorespiratory nasopharyngeal reflexes in the rabbit

1975 ◽  
Vol 228 (2) ◽  
pp. 404-409 ◽  
Author(s):  
S White ◽  
RJ McRitchie ◽  
PI Korner
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Carotid Sinus ◽  
Cerebral Hemispheres ◽  
System Control ◽  
Controlled Ventilation ◽  
Cardiovascular Reflex ◽  
Respiratory Reflex ◽  
Central Nervous System Control

The role of different central nervous regions in the reflex apnea, bradycardia, and mesenteric vasoconstriction evoked by nasopharyngeal stimulation with cigarette smoke was examined in unanesthetized shamoperated, thalamic, and pontine rabbits with intact and sectioned carotid sinus and aortic nerves (CS and AN). Apnea occurred in all preparations. In pontine animals with intact CS and AN, the heart rate response was reduced but not the mesenteric vasoconstriction. The role of suprabulbar and bulbospinal regions became more apparent when individual components of the input profile were examined in animals with controlled ventilation. The bradycardia and mesenteric vasoconstriction evoked by apnea without smoke, but not by smoke without apnea, were reduced in pontine animals. Prior section of the CS and AN attenuated the response in all neural preparations but to the least extent when cerebral hemispheres were intact. The data indicate that the respiratory reflex is predominantly integrated at bulbospinal sites, but the cardiovascular reflex is integrated at both bulbospinal and suprabulbar sites, or is integrated at bulbospinal and modulated from suprabulbar sites.

Functional Asymmetry of the Cerebral Hemispheres: Its Role in the Pathogenesis of Ectromelia and Melanoma in (CBAxC57BL/6)F1 Mice

2010 ◽  
Vol 40 (7) ◽  
pp. 733-736
Author(s):  
V. V. Abramov ◽  
I. A. Gontova ◽  
I. M. Ignatiev ◽  
E. L. Gelfgat ◽  
V. A. Kozlov
Keyword(s):  
Functional Asymmetry ◽  
Cerebral Hemispheres

Thrombopoietin Has Neural Protective Effect in a Neonatal Rat Model of Hypoxic-Ischemic Brain Damage

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 5059-5059 ◽  
Author(s):  
Mo Yang ◽  
Lei Liu ◽  
Enyu Liang ◽  
Beng H Chong ◽  
Chunfu Li
Keyword(s):  
Brain Damage ◽  
Rat Model ◽  
Akt Signaling ◽  
Cerebral Hemispheres ◽  
Neonatal Rat ◽  
Neural Cells ◽  
Rt Pcr ◽  
Hematopoietic Growth Factors ◽  
Neonatal Rat Model

Abstract Objective: The infusion of bone marrow cells into the damaged brain has been proposed as a new clinical practice for this disorder. Alternatively, hematopoietic growth factors may have a direct role on neural protection or have a mobilizing effect on bone marrow stem/progenitor cells to circulation for brain repair. Based on our previous findings, there are many similarities between megakaryocytes and neurons on functions and antigen expression such as neural marker MAP2, GFAP and Tau, 5-HT2A, 2B and 2C receptors (Stem Cells, 2014). Thrombopoietin (TPO) is a growth factor for megakaryocytic lineage. We postulate that TPO may play a role on neural protection or regeneration. The effect of TPO on nervous system has not been well investigated. Methods: To validate this hypothesis, we investigated the expression and role of TPO/TPO receptors in neural cells and a neonatal rat model of hypoxic-ischemic (HIE) brain damage. Results: To investigate the effect of TPO on in-vivo neural protection, a neonatal rat model of HIE brain damage was established. Brain injury was measured by the percentage weight reduction of the ipsilateral cerebral hemisphere as compared to the contralateral hemisphere. There was significantly less brain atrophy in TPO treated animals (12.0±1.2% and 11.5±1.0%) when compared with the saline control (21.0±1.6% and 24.4±2.2%) at 7 and 28 days post-operation (P<0.05, n=12). The percentage of NSE (Neuron-specific enolase) positive cells in the forelimb area of the cortex in the right hemisphere was significantly higher in the TPO group than that of the saline group (P<0.05, n=12). An improvement in sensory motor functions was also demonstrated after TPO treatment. TPO mRNA was also identified in human cerebral hemispheres, cerebellum, and mouse neural stem cell line C17.2 by RT-PCR methods. TPO protein was detected in human cerebrospinal fluids (n=10) by ELISA. Moreover, TPO receptor (c-mpl) mRNA was identified in human cerebral hemispheres and cerebellum, and C17.2 cells using RT-PCR. The expression of c-mpl protein was also confirmed on neurons in the human cerebral hemispheres, hippocampus, cerebellum, brainstem and spinal cord using immune-cytochemical staining. TPO also showed a stimulating effect on the in-vitro growth of C17.2 cells by the MTT assay. TPO activated the phosphoinositide 3-kinase(PI3K)/Akt signaling pathway which was demonstrated by Western blot. The Akt activation by TPO was inhibited by the PI3-kinase inhibitor LY294002. Conclusions: Our study provided the evidences showing the expression of TPO and TPO receptor (c-mpl) in neural cells and this effect may be mediated by c-mpl and Akt signaling. More importantly, our observation further demonstrated the functional role of TPO on neural protection in a rat model. These findings point to the possibility of a new strategy for treating brain damage by hematopoietic growth factors. Disclosures Yang: National Natural Science Foundation of China: Other: National Natural Science Foundation of China(81270580).

Post-Stroke Neurological Impairments in Rats with Functional Asymmetry of the Cerebral Hemispheres

2011 ◽  
Vol 41 (8) ◽  
pp. 865-870
Author(s):  
A. I. Volkov ◽  
S. V. Lebedev ◽  
E. P. Starykh ◽  
N. A. Volkova ◽  
V. P. Chekhonin
Keyword(s):  
Functional Asymmetry ◽  
Cerebral Hemispheres ◽  
Post Stroke

Role of Cerebral Hemispheres and Regions in Processing Hemifacial Expression of Emotion: Evidence from Brain-Damage

1992 ◽  
Vol 63 (3-4) ◽  
pp. 187-195 ◽  
Author(s):  
M. K. Mandal ◽  
H. S. Asthana ◽  
S. C. Tandon ◽  
S. Asthana
Keyword(s):  
Brain Damage ◽  
Cerebral Hemispheres ◽  
Expression Of Emotion
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