Detection and cytoplasmic localization of two different microtubule motor proteins in basal epithelial cells of freshwater sponges

PROTOPLASMA ◽  
1997 ◽  
Vol 196 (3-4) ◽  
pp. 167-180 ◽  
Author(s):  
G. Kirfel ◽  
W. Stockem
Keyword(s):  
Epithelial Cells ◽  
Motor Proteins ◽  
Cytoplasmic Localization ◽  
Freshwater Sponges ◽  
Microtubule Motor ◽  
Basal Epithelial Cells

scholarly journals β-Catenin regulates P-cadherin expression in mammary basal epithelial cells

FEBS Letters ◽  
2007 ◽  
Vol 581 (5) ◽  
pp. 831-836 ◽  
Author(s):  
Marisa M. Faraldo ◽  
Jérôme Teulière ◽  
Marie-Ange Deugnier ◽  
Walter Birchmeier ◽  
Joerg Huelsken ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Basal Epithelial Cells

scholarly journals 2018 PLOS Genetics Research Prize: Bundling, stabilizing, organizing—The orchestration of acentriolar spindle assembly by microtubule motor proteins

PLoS Genetics ◽  
2018 ◽  
Vol 14 (9) ◽  
pp. e1007649
Author(s):  
Gregory S. Barsh ◽  
Needhi Bhalla ◽  
Francesca Cole ◽  
Gregory P. Copenhaver ◽  
Soni Lacefield ◽  
...  
Keyword(s):  
Motor Proteins ◽  
Spindle Assembly ◽  
Genetics Research ◽  
Microtubule Motor

scholarly journals Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells

2007 ◽  
Vol 179 (6) ◽  
pp. 1133-1140 ◽  
Author(s):  
Jeff Sfakianos ◽  
Akashi Togawa ◽  
Sandra Maday ◽  
Mike Hull ◽  
Marc Pypaert ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Primary Cilium ◽  
Basolateral Membrane ◽  
Intraflagellar Transport ◽  
Binding Motif ◽  
Apical Surface ◽  
Anterograde Transport ◽  
Ciliary Membrane ◽  
Microtubule Motor ◽  
Dependent Transport

Par3 is a PDZ protein important for the formation of junctional complexes in epithelial cells. We have identified an additional role for Par3 in membrane biogenesis. Although Par3 was not required for maintaining polarized apical or basolateral membrane domains, at the apical surface, Par3 was absolutely essential for the growth and elongation of the primary cilium. The activity reflected its ability to interact with kinesin-2, the microtubule motor responsible for anterograde transport of intraflagellar transport particles to the tip of the growing cilium. The Par3 binding partners Par6 and atypical protein kinase C interacted with the ciliary membrane component Crumbs3 and we show that the PDZ binding motif of Crumbs3 was necessary for its targeting to the ciliary membrane. Thus, the Par complex likely serves as an adaptor that couples the vectorial movement of at least a subset of membrane proteins to microtubule-dependent transport during ciliogenesis.

Microtubule motor proteins and the organization of the pollen tube cytoplasm

2001 ◽  
Vol 14 (1-2) ◽  
pp. 27-34 ◽  
Author(s):  
Silvia Romagnoli ◽  
Mauro Cresti ◽  
G. Cai
Keyword(s):  
Pollen Tube ◽  
Motor Proteins ◽  
Microtubule Motor

scholarly journals Activity of the Human Papillomavirus Type 16 Late Negative Regulatory Element Is Partly due to Four Weak Consensus 5′ Splice Sites That Bind a U1 snRNP-Like Complex

2003 ◽  
Vol 77 (9) ◽  
pp. 5167-5177 ◽  
Author(s):  
Sarah A. Cumming ◽  
Maria G. McPhillips ◽  
Thanaporn Veerapraditsin ◽  
Steven G. Milligan ◽  
Sheila V. Graham
Keyword(s):  
Gene Expression ◽  
Human Papillomavirus ◽  
Epithelial Cells ◽  
Regulatory Element ◽  
Splice Sites ◽  
Hpv 16 ◽  
Negative Regulatory Element ◽  
Differentiated Cells ◽  
U1 Snrnp ◽  
Basal Epithelial Cells

ABSTRACT The human papillomavirus (HPV) life cycle is tightly linked to differentiation of the squamous epithelia that it infects. Capsid proteins, and hence mature virions, are produced in the outermost layer of differentiated cells. As late gene transcripts are produced in the lower layers, posttranscriptional mechanisms likely prevent capsid protein production in less differentiated cells. For HPV type 16 (HPV-16), a 79-nucleotide (nt) negative regulatory element (NRE) inhibits gene expression in basal epithelial cells. To identify key NRE sequences, we carried out transient transfection in basal epithelial cells with reporter constructs containing the HPV-16 late 3′ untranslated region with deletions and mutations of the NRE. Reporter gene expression was increased over 40-fold by deletion of the entire element, 10-fold by deletion of the 5′ portion of the NRE that contains four weak consensus 5′ splice sites, and only 3-fold by deletion of the 3′ GU-rich region. Both portions of the element appear to be necessary for full repression. Inactivating mutations in the 5′ splice sites in the 5′ NRE partially alleviated repression in the context of the 79-nt NRE but caused full derepression when assayed in a construct with the 3′ NRE deleted. All four contribute to the inhibitory effect, though the second splice site is most inhibitory. Sm proteins, U1A and U1 snRNA, but not U1 70K, could be affinity purified with the wild-type NRE but not with the NRE containing mutations in the 5′ splice sites, indicating that a U1 snRNP-like complex forms upon the element.

scholarly journals Toxic Effects of the Major Components of Diesel Exhaust in Human Alveolar Basal Epithelial Cells (A549)

2016 ◽  
Vol 17 (9) ◽  
pp. 1393 ◽  
Author(s):  
Pavel Rossner ◽  
Simona Strapacova ◽  
Jitka Stolcpartova ◽  
Jana Schmuczerova ◽  
Alena Milcova ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Diesel Exhaust ◽  
Toxic Effects ◽  
Basal Epithelial Cells

Phosphotyrosine Antibodies Preferentially React with Basal Epithelial Cells in the Dog Prostate

1996 ◽  
Vol 155 (1) ◽  
pp. 386-390 ◽  
Author(s):  
France Landry ◽  
Alcide Chapdelaine ◽  
Louis R. Begin ◽  
Simone Chevalier
Keyword(s):  
Epithelial Cells ◽  
Basal Epithelial Cells
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