A double-blind study of prophylactic effect of misoprostol on lesions of gastric and duodenal mucosa induced by oral administration of tolmetin in healthy subjects

1. A double-blind study was undertaken to determine whether the infusion of bombesin inhibits the intake of a carbohydrate-rich meal, consumed 15 min after a 300 ml banana shake, in nine lean healthy subjects and whether the possible inhibition of food intake by bombesin is mediated by cholecystokinin. 2. The amount of food eaten during infusion of bombesin (267 ±60 g) and bombesin combined with the cholecystokinin-receptor antagonist loxiglumide (269±39g) was slightly (P = 0.09) less than during saline infusion (384 ± 40 g). In addition, preprandial feelings of hunger were significantly less during infusion of both bombesin and bombesin combined with loxiglumide. 3. In conclusion, infusion of bombesin tends to inhibit the intake of a carbohydrate-rich meal after a preload by a cholecystokinin-independent mechanism.

Download Full-text

III. A DOUBLE BLIND STUDY OF THE PROPHYLACTIC EFFECT OF LITHIUM IN MANIC-DEPRESSIVE DISEASE

Acta Psychiatrica Scandinavica ◽

10.1111/j.1600-0447.1977.tb10821.x ◽

1977 ◽

Vol 56 ◽

pp. 16-22 ◽

Cited By ~ 2

Author(s):

B. Fyrö ◽

U. Petterson

Keyword(s):

Blind Study ◽

Double Blind Study ◽

Prophylactic Effect ◽

Double Blind ◽

Manic Depressive

Download Full-text

A Double Blind Study of the Effect of Tranexamic Acid in Essential Menorrhagia

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651301 ◽

1968 ◽

Vol 20 (03/04) ◽

pp. 583-587 ◽

Cited By ~ 21

Author(s):

J Vermylen ◽

M. L Verhaegen-Declercq ◽

M Verstraete ◽

F Fierens

Keyword(s):

Side Effects ◽

Oral Administration ◽

Tranexamic Acid ◽

Blind Study ◽

Double Blind Study ◽

Double Blind

SummaryOral administration of tranexamic acid, in a dosage of 3 g daily from the first day of menstruation onwards, significantly decreases menstrual haemoglobin loss in women with so-called essential menorrhagia.The frequency of side-effects reported did not differ between “active” and “placebo” periods.

Download Full-text

A Double-Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2018/8128147 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11

Author(s):

Masako Nishiwaki ◽

Miho Takayama ◽

Hiroyoshi Yajima ◽

Morihiro Nasu ◽

Joel Park ◽

...

Keyword(s):

General Hospital ◽

Healthy Subjects ◽

Massachusetts General Hospital ◽

Blind Study ◽

Double Blind Study ◽

Insertion Depth ◽

Double Blind ◽

Acupuncture Sensation

To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly administered at various insertion depths (5 and 10 mm for the penetrating needles and 1 and 2 mm for the placebo needles) at LI4 to 50 healthy subjects. Among the 12 acupuncture sensations in the Massachusetts General Hospital Acupuncture Sensation Scale (MASS), “heaviness” was the strongest and most frequently reported sensation with the 10 mm needles, but not with the 5 mm needles. There were no significant differences in number of sensations elicited, MASS index, range of spreading, and intensity of needle pain for 5 mm penetration versus 1 mm skin press and 10 mm penetration versus 2 mm skin press. The MASS index with 2 mm skin-touch needles was significantly larger than that with 1 mm skin-touch and 5 mm penetrating needles. The factor structures in the 12 acupuncture sensations between penetrating and skin-touch needles were different. The acupuncture sensations obtained in this study under satisfactorily performed double-blind (practitioner–patient) conditions suggest that a slight difference in insertion depth and skin press causes significant differences in quantity and quality of acupuncture sensations.

Download Full-text