A unifying concept of polymorphonuclear neutrophil function in acute bacterial infection

1983 ◽  
Vol 7 (3) ◽  
pp. 424-429 ◽  
Author(s):  
Z. H. Krukowski ◽  
G. Smith
Keyword(s):  
Bacterial Infection ◽  
Neutrophil Function ◽  
Polymorphonuclear Neutrophil

scholarly journals Macrophage Inflammatory Protein-2 Is a Mediator of Polymorphonuclear Neutrophil Influx in Ocular Bacterial Infection

2000 ◽  
Vol 164 (2) ◽  
pp. 1037-1045 ◽  
Author(s):  
Karen A. Kernacki ◽  
Ronald P. Barrett ◽  
Jeffery A. Hobden ◽  
Linda D. Hazlett
Keyword(s):  
Bacterial Infection ◽  
Polymorphonuclear Neutrophil ◽  
Neutrophil Influx ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

Acquired abnormalities of polymorphonuclear neutrophil function

Blood Reviews ◽  
1990 ◽  
Vol 4 (2) ◽  
pp. 103-110 ◽  
Author(s):  
J. Fletcher ◽  
A.P. Haynes ◽  
S.M. Crouch
Keyword(s):  
Neutrophil Function ◽  
Polymorphonuclear Neutrophil ◽  
Acquired Abnormalities

scholarly journals Neutrophil Function Impairment Is a Host Susceptibility Factor to Bacterial Infection in Diabetes

2020 ◽  
Author(s):  
Daniella Insuela ◽  
Diego Coutinho ◽  
Marco Martins ◽  
Maximiliano Ferrero ◽  
Vinicius Carvalho
Keyword(s):  
Bacterial Infection ◽  
Neutrophil Function ◽  
Host Susceptibility ◽  
Susceptibility Factor ◽  
Function Impairment

scholarly journals Reducing the incidence of acute puerperal metritis in primiparous cows by application of pegbovigrastim in a Holstein dairy herd

2018 ◽  
Vol 63 (No. 4) ◽  
pp. 151-160 ◽  
Author(s):  
M. Freick ◽  
M. Zenker ◽  
O. Passarge ◽  
J. Weber
Keyword(s):  
Milk Fat ◽  
Animal Health ◽  
Dairy Herd ◽  
Neutrophil Function ◽  
Milk Composition ◽  
Clinical Mastitis ◽  
Polymorphonuclear Neutrophil ◽  
Control Group ◽  
Relative Reduction ◽  
Beneficial Effects

In dairy cows, immunosuppression occurs frequently during the periparturient period and is characterised by transient neutropenia and impaired polymorphonuclear neutrophil function. As a consequence, postpartum cows are more susceptible to production-related diseases such as mastitis, retained foetal membranes and metritis. Recently, it has been shown that a double injection with recombinant bovine granulocyte colony-stimulating factor covalently bound to polyethylene glycol (PEG rbG-CSF) increased polymorphonuclear neutrophil number and the exocytosis of myeloperoxidase by stimulating polymorphonuclear neutrophil, which also played a role in innate uterine immune defence. The aim of this randomised clinical study was to investigate the effects of two periparturient PEG rbG-CSF injections (IMR; Imrestor<sup>TM</sup>, Elanco Animal Health, Bad Homburg/Germany) on the incidence of acute puerperal metritis, number of antibiotic doses required for treatment of acute puerperal metritis as well as parameters of milking performance (i.e., milk yield, milk fat, milk protein, and somatic cell count on the first dairy herd improvement test day) in primiparous cows within a dairy herd with an elevated incidence of acute puerperal metritis. In total, 169 heavily pregnant heifers were randomly assigned to the treatment group (IMR: n = 82) who received 15 mg PEG rbG-CSF subcutaneously 10 ± 3 days before the anticipated calving date and within 24 hours after calving, or to the untreated control group (Co: n = 87). In total, data from 157 animals (IMR: n = 75, Co: n = 82) were analysed. Administration of PEG rbG-CSF reduced the incidence of acute puerperal metritis in primiparous cows significantly (IMR: 22.7%, Co: 43.9%, P = 0.003; relative reduction: 48.3%). Moreover, the number of antibiotic doses per calving required for treatment of acute puerperal metritis was significantly lower in the pegbovigastrim group (IMR: 0.32 ± 0.66, Co: 0.59 ± 0.75, P = 0.005). No significant differences regarding incidence of clinical mastitis, milk production or milk composition were observed. These results suggest that further research should be performed to identify herd- and animal-specific factors that can be predictors of the beneficial effects of pegbovigrastim in preventing uterine diseases.

scholarly journals Interferon-gamma activation of polymorphonuclear neutrophil function

Immunology ◽  
2004 ◽  
Vol 112 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Terri N. Ellis ◽  
Blaine L. Beaman
Keyword(s):  
Interferon Gamma ◽  
Neutrophil Function ◽  
Polymorphonuclear Neutrophil ◽  
Gamma Activation

Impairment of Polymorphonuclear Neutrophil Function in HIV-Infected Patients

1995 ◽  
Vol 25 ◽  
pp. S66-S70 ◽  
Author(s):  
C. Elbim ◽  
M. H. Prevot ◽  
F. Bouscarat ◽  
E. Franzini ◽  
S. Chollet-Martin ◽  
...  
Keyword(s):  
Neutrophil Function ◽  
Polymorphonuclear Neutrophil

scholarly journals Polymorphonuclear neutrophil function in malignant lymphomas and effects of splenectomy

Cancer ◽  
1980 ◽  
Vol 45 (3) ◽  
pp. 469-475 ◽  
Author(s):  
Vladimir Von Fliedner ◽  
Vincent Salvatori ◽  
Donald J. Higby ◽  
Leon Stutzman ◽  
Byung H. Park
Keyword(s):  
Neutrophil Function ◽  
Polymorphonuclear Neutrophil ◽  
Malignant Lymphomas
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