Macrophage Inflammatory Protein-2 Is a Mediator of Polymorphonuclear Neutrophil Influx in Ocular Bacterial Infection

We have studied the recruitment and roles of distinct dendritic cell (DC) precursors from the circulation into Propionibacterium acnes–induced granulomas in mouse liver. During infection, F4/80−B220−CD11c+ DC precursors appeared in the circulation, migrated into the perisinusoidal space, and matured within newly formed granulomas. Recruited DCs later migrated to the portal area to interact with T cells in what we term “portal tract–associated lymphoid tissue” (PALT). Macrophage inflammatory protein 1α attracted blood DC precursors to the sinusoidal granuloma, whereas secondary lymphoid organ chemokine (SLC) attracted mature DCs to the newly identified PALT. Anti-SLC antibody diminished PALT expansion while exacerbating granuloma formation. Therefore, circulating DC precursors can migrate into a solid organ like liver, and participate in the granulomatous reaction in response to specific chemokines.

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Chemokine Macrophage Inflammatory Protein-1α mRNA Expression in Lung Biopsy Specimens of Primary Pulmonary Hypertension

CHEST Journal ◽

10.1378/chest.114.1_supplement.50s ◽

1998 ◽

Vol 114 (1) ◽

pp. 50S-51S ◽

Cited By ~ 53

Author(s):

M. Fartoukh ◽

D. Emilie ◽

C. Le Gall ◽

G. Monti ◽

Gerald Simonneau ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Mrna Expression ◽

Lung Biopsy ◽

Primary Pulmonary Hypertension ◽

Biopsy Specimens ◽

Inflammatory Protein ◽

Macrophage Inflammatory Protein

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Roles of Interleukin‐6 and Macrophage Inflammatory Protein–2 in Pneumolysin‐Induced Lung Inflammation in Mice

The Journal of Infectious Diseases ◽

10.1086/338008 ◽

2002 ◽

Vol 185 (1) ◽

pp. 123-126 ◽

Cited By ~ 49

Author(s):

Anita W. Rijneveld ◽

Germie P. van den Dobbelsteen ◽

Sandrine Florquin ◽

Theodore J. Standiford ◽

Peter Speelman ◽

...

Keyword(s):

Interleukin 6 ◽

Lung Inflammation ◽

Inflammatory Protein ◽

Macrophage Inflammatory Protein

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Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression

Mediators of Inflammation ◽

10.1080/09511920410001713484 ◽

2004 ◽

Vol 13 (3) ◽

pp. 205-207 ◽

Cited By ~ 21

Author(s):

Rosaria Alba Merendino ◽

Giuseppe Di Pasquale ◽

Filippo De Luca ◽

Laura Di Pasquale ◽

Edoardo Ferlazzo ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Immune Therapy ◽

Severe Depression ◽

Mononuclear Phagocytes ◽

Cytokines And Chemokines ◽

Inflammatory Protein ◽

Healthy Donors ◽

The Central Nervous System ◽

Macrophage Inflammatory Protein

MODERATE-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1α) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1α in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1α was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.

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