Recombinant human interferon γ exerts an anti-proliferative effect and modulates the expression of human leukocyte antigens A,B,C and DR in human urothelial cell lines

1990 ◽  
Vol 31 (2) ◽  
pp. 93-98 ◽  
Author(s):  
S. S. Ottesen ◽  
V. Ahrenkiel ◽  
J. Kieler
Keyword(s):  
Cell Lines ◽  
Human Leukocyte ◽  
Interferon Γ ◽  
Urothelial Cell ◽  
Human Interferon ◽  
Human Leukocyte Antigens ◽  
Proliferative Effect ◽  
Leukocyte Antigens ◽  
Human Urothelial Cell

Anti-Proliferative Effect on Human Pancreatic Cancer Cells of Natural Human Tumour Necrosis Factor-β Combined with Natural Human Interferon-α or Interferon-γ

1992 ◽  
Vol 20 (2) ◽  
pp. 112-120 ◽  
Author(s):  
T Watanabe ◽  
S Fuchimoto ◽  
N Matsubara ◽  
H Iwagaki ◽  
K Orita
Keyword(s):  
Pancreatic Cancer ◽  
Tumour Necrosis Factor ◽  
Cell Lines ◽  
Tumour Necrosis ◽  
Interferon Γ ◽  
Human Pancreatic Cancer ◽  
Human Interferon ◽  
Interferon Α ◽  
Proliferative Effect ◽  
Necrosis Factor

The anti-proliferative effects of natural cytokines, human tumour necrosis factor-β, natural human interferon-α and natural human interferon-γ, on three human pancreatic cancer cell lines (PANC-1, MIA PaCa-2 and BxPC-3) were investigated in vitro. The anti-proliferative effect was determined using the dye uptake method and analysed for synergism by the median effect principle. Tumour necrosis factor-β, as a single agent, had little anti-proliferative effect on any of the three cell lines, whereas interferon-α and interferon-γ exhibited a strong anti-proliferative effect against two cell lines (MIA PaCa-2 and BxPC-3) and one cell line (BxPC-3), respectively. When tumour necrosis factor-β and interferon-α were administered together (ratio 1:1), a synergistic effect was observed against PANC-1 cells. The combination of tumour necrosis factor-β and interferon-γ (ratio 10:1) was synergisic against both PANC-1 and MIA PaCa-2 cells. A synergistic anti-proliferative effect of tumour necrosis factor-β and interferons was, therefore, observed even for cell lines that showed little biological response to each cytokine alone. The data suggest that some future improvement in the treatment of pancreatic cancer may be obtained by using combination cytokine therapy.

Soluble Human Leukocyte Antigens, Interleukin-6, and Interferon-γ During Pregnancy

1997 ◽  
Vol 38 (4) ◽  
pp. 256-262 ◽  
Author(s):  
G.P. Russwurm ◽  
A.M. Mackler ◽  
O.R. Fagoaga ◽  
W.S. Brown ◽  
E.P. Sakala ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Human Leukocyte ◽  
Interferon Γ ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens

scholarly journals Human leukocyte antigens are associated with salivary level of active MMP ‐8

2021 ◽  
Author(s):  
Matti Mauramo ◽  
Elina Mauramo ◽  
Timo Sorsa ◽  
Taina Tervahartiala ◽  
Ismo T. Räisänen ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens ◽  
Salivary Level

scholarly journals Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection

Cell Reports ◽  
2021 ◽  
Vol 36 (7) ◽  
pp. 109538
Author(s):  
Audrey V. Parent ◽  
Gaetano Faleo ◽  
Jessica Chavez ◽  
Michael Saxton ◽  
David I. Berrios ◽  
...  
Keyword(s):  
Stem Cell ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Immune Rejection ◽  
Leukocyte Antigens

scholarly journals Genetic Association of Human Leukocyte Antigens with Chronicity or Resolution of Hepatitis B Infection in Thai Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86007 ◽  
Author(s):  
Nawarat Posuwan ◽  
Sunchai Payungporn ◽  
Pisit Tangkijvanich ◽  
Shintaro Ogawa ◽  
Shuko Murakami ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Genetic Association ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Hepatitis B Infection ◽  
Thai Population ◽  
Leukocyte Antigens

SARS-CoV-2 and Human Leukocyte Antigens

2021 ◽  
Vol 67 (04/2021) ◽  
Author(s):  
Daming Wang ◽  
Wen Ma ◽  
Hongwei Shen ◽  
Yiwen Zhou
Keyword(s):  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens

The pro-proliferative effect of interferon-γ in breast cancer cell lines is dependent on stimulation of ASCT2-mediated glutamine cellular uptake

Life Sciences ◽  
2021 ◽  
pp. 120054
Author(s):  
Cláudia Silva ◽  
Nelson Andrade ◽  
Ilda Rodrigues ◽  
António Carlos Ferreira ◽  
Miguel Luz Soares ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cellular Uptake ◽  
Cancer Cell Lines ◽  
Interferon Γ ◽  
Breast Cancer Cell Lines ◽  
Proliferative Effect ◽  
Stimulation Of
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