The pro-proliferative effect of interferon-γ in breast cancer cell lines is dependent on stimulation of ASCT2-mediated glutamine cellular uptake

Life Sciences ◽  
2021 ◽  
pp. 120054
Author(s):  
Cláudia Silva ◽  
Nelson Andrade ◽  
Ilda Rodrigues ◽  
António Carlos Ferreira ◽  
Miguel Luz Soares ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cellular Uptake ◽  
Cancer Cell Lines ◽  
Interferon Γ ◽  
Breast Cancer Cell Lines ◽  
Proliferative Effect ◽  
Stimulation Of

Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy

2017 ◽  
Vol 68 (4) ◽  
pp. 754-757 ◽  
Author(s):  
George Mihai Nitulescu ◽  
George Iancu ◽  
Georgiana Nitulescu ◽  
Raluca Claudia Iancu ◽  
Camelia Bogdanici ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Biology ◽  
Rational Design ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Proliferative Effect

Breast cancer research is a priority nowadays because of the high burden the disease represents for health systems worldwide. New agents are intensively researched to overcome breast cancer biology. Our aminopyrazole derivatives showed promising results when tested in vitro on breast cancer cell lines, by inhibiting protein kinase pathways. Anti-proliferative effect of pyrazole compounds on different breast cancer cell lines was heterogeneous. Further research is necessary to design the optimal structure in terms of high antitumor efficacy and good safety profile. Ophthalmologist control is very important for patients with breast cancer because treatment with some drugs reported side ocular effects: cataract, maculopathy (crystals or drusen or yellowish spots), retinal hemorrhages or dry.

scholarly journals Interactions of BRCA1-mutated Breast Cancer Cell Lines with Adipose-derived Stromal Cells (ADSCs)

2021 ◽  
Author(s):  
Adelina Plangger ◽  
Werner Haslik ◽  
Barbara Rath ◽  
Christoph Neumayer ◽  
Gerhard Hamilton
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Stromal Cells ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Adipose Derived Stromal Cells ◽  
Stimulation Of

AbstractLipofilling may constitute a technique to assist reconstruction of breasts following prophylactic mastectomy for patients with mutated BRCA1 or BRCA2 genes. However, to date it is not clear whether adipose-derived stromal cells (ADSCs) increase the risk of tumor initiation and progression in this situation. Therefore, the interactions of BRCA1 mutated breast cancer cell lines with normal ADSCs were investigated in the present study. Characteristics of MDA-MB-436 (BRCA1 c.5277 + 1G > A) and HCC1937 (BRCA1 p.Gln1756.Profs*74) were compared to MDA-MB-231 and T47D BRCA1/2 wild-type breast cancer cell lines. ADSCs were cultivated from lipoaspirates of a panel of BRCA1/2- wildtype patients. Interactions of conditioned medium (CM) of these cells with the breast cancer lines were studied using proliferation and migration assays as well as adipokine expression western blot arrays. CM of ADSCs exhibit a dose-dependent stimulation of the proliferation of the breast cancer cell lines. However, of the ADSC preparations tested, only 1 out of 18 samples showed a significant higher stimulation of BRCA1-mutated MDA-MB-436 versus wildtype MDA-MB-231 cells, and all CM revealed lower stimulatory activity for BRCA1-mutated HCC1937 versus wildtype T47D cells. Additionally, migration of breast cancer cells in response to CM of ADSCs proved to be equivalent or slower for BRCA1/2 mutated versus nonmutated cancer cells and, with exception of angiopoietin-like 2, induced expression of adipokines showed no major difference. Effects of media conditioned by normal ADSCs showed largely comparable effects on BRCA1-mutated and wildtype breast cancer cell lines thus advocating lipofilling, preferentially employing allogeneic non-mutated ADSCs.

Insights into the Cellular Uptake, Cytotoxicity, and Cellular Death Modality of Phospholipid-Coated Gold Nanorods toward Breast Cancer Cell Lines

2019 ◽  
Vol 16 (10) ◽  
pp. 4149-4164 ◽  
Author(s):  
Nouf N. Mahmoud ◽  
Rana Abu-Dahab ◽  
Lama A. Hamadneh ◽  
Duaa Abuarqoub ◽  
Hanan Jafar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cellular Death

Anti-proliferative effect of biogenic gold nanoparticles against breast cancer cell lines (MDA-MB-231 & MCF-7)

2016 ◽  
Vol 371 ◽  
pp. 415-424 ◽  
Author(s):  
Uma Suganya K.S. ◽  
Govindaraju K. ◽  
Ganesh Kumar V. ◽  
Prabhu D. ◽  
Arulvasu C. ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Proliferative Effect ◽  
Mcf 7
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