Oscillatory activation of calcium-dependent potassium channels in HeLa cells induced by histamine H1 receptor stimulation: A single-channel study

1987 ◽  
Vol 96 (3) ◽  
pp. 199-208 ◽  
Author(s):  
R. Sauvé ◽  
C. Simoneau ◽  
L. Parent ◽  
R. Monette ◽  
G. Roy
Keyword(s):  
Potassium Channels ◽  
Hela Cells ◽  
Single Channel ◽  
H1 Receptor ◽  
Receptor Stimulation ◽  
Histamine H1 Receptor ◽  
Calcium Dependent

Ca2+ oscillations induced by histamine H1 receptor stimulation in HeLa cells: Fura-2 and patch clamp analysis

Cell Calcium ◽  
1991 ◽  
Vol 12 (2-3) ◽  
pp. 165-176 ◽  
Author(s):  
R. Sauvé ◽  
A. Diarra ◽  
M. Chahine ◽  
C. Simoneau ◽  
N. Morier ◽  
...  
Keyword(s):  
Patch Clamp ◽  
Hela Cells ◽  
H1 Receptor ◽  
Receptor Stimulation ◽  
Histamine H1 Receptor ◽  
Fura 2

Effects of histamine H1-receptor stimulation on coronary hemodynamics in man

1985 ◽  
Vol 17 (1) ◽  
pp. 38-41 ◽  
Author(s):  
C. Vigorito ◽  
S. Poto ◽  
M. Triggiani ◽  
M. Rispoli ◽  
G. Marone
Keyword(s):  
H1 Receptor ◽  
Receptor Stimulation ◽  
Histamine H1 Receptor

scholarly journals Signaling Pathway of Histamine H1 Receptor-Mediated Histamine H1 Receptor Gene Upregulation Induced by Histamine in U-373 MG Cells

2021 ◽  
Vol 43 (3) ◽  
pp. 1243-1254
Author(s):  
Hiroyuki Mizuguchi ◽  
Yuko Miyamoto ◽  
Takuma Terao ◽  
Haruka Yoshida ◽  
Wakana Kuroda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathway ◽  
Hela Cells ◽  
Time Course ◽  
Receptor Gene ◽  
Selective Inhibitor ◽  
H1 Receptor ◽  
Promoter Assay ◽  
Peripheral Tissues ◽  
Histamine H1 Receptor

Histamine H1 receptor (H1R) is one of the targets of histamine in the nervous system and the peripheral tissues. Protein kinase Cδ (PKCδ) signaling is involved in histamine-induced upregulation of H1R gene expression in HeLa cells. Histamine also upregulates H1R gene expression in U-373 MG cells. However, the molecular signaling of this upregulation is still unclear. Here, we investigated the molecular mechanism of histamine-induced H1R gene upregulation in U-373 MG cells. Histamine-induced H1R gene upregulation was inhibited by H1R antagonist d-chlorpheniramine, but not by ranitidine, ciproxifan, or JNJ77777120, and H2R, H3R, or H4R antagonists, respectively. Ro-31-8220 and Go6976 also suppressed this upregulation, however, the PKCδ selective inhibitor rottlerin and the PKCβ selective inhibitor Ly333531 did not. Time-course studies showed distinct kinetics of H1R gene upregulation in U-373 MG cells from that in HeLa cells. A promoter assay revealed that the promoter region responsible for H1R gene upregulation in U-373 MG cells was different from that of HeLa cells. These data suggest that the H1R-activated H1R gene expression signaling pathway in U-373 MG cells is different from that in HeLa cells, possibly by using different promoters. The involvement of PKCα also suggests that compounds that target PKCδ could work as peripheral type H1R-selective inhibitors without a sedative effect.

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