Effects of dopamine on total peripheral resistance and integrated systemic venous blood volume in dogs

1980 ◽  
Vol 75 (5) ◽  
pp. 623-634 ◽  
Author(s):  
E. Grund ◽  
E. R. Müller-Ruchholtz ◽  
F. Hauer ◽  
E. R. Lapp
1988 ◽  
Vol 254 (4) ◽  
pp. H811-H815 ◽  
Author(s):  
D. G. Parkes ◽  
J. P. Coghlan ◽  
J. G. McDougall ◽  
B. A. Scoggins

The hemodynamic and metabolic effects of long-term (5 day) infusion of human atrial natriuretic factor (ANF) were examined in conscious chronically instrumented sheep. Infusion of ANF at 20 micrograms/h, a rate below the threshold for an acute natriuretic effect, decreased blood pressure by 9 +/- 1 mmHg on day 5, associated with a fall in calculated total peripheral resistance. On day 1, ANF reduced cardiac output, stroke volume, and blood volume, effects that were associated with an increase in heart rate and calculated total peripheral resistance and a small decrease in blood pressure. On days 4 and 5 there was a small increase in urine volume and sodium excretion. On day 5 an increase in water intake and body weight was observed. No change was seen in plasma concentrations of renin, arginine vasopressin, glucose, adrenocorticotropic hormone, or protein. This study suggests that the short-term hypotensive effect of ANF results from a reduction in cardiac output associated with a fall in both stroke volume and effective blood volume. However, after 5 days of infusion, ANF lowers blood pressure via a reduction in total peripheral resistance.


2017 ◽  
Vol 22 (2) ◽  
pp. 025001 ◽  
Author(s):  
Martin B. Rasmussen ◽  
Vibeke R. Eriksen ◽  
Bjørn Andresen ◽  
Simon Hyttel-Sørensen ◽  
Gorm Greisen

NeuroImage ◽  
2012 ◽  
Vol 60 (4) ◽  
pp. 2238-2246 ◽  
Author(s):  
Xiaopeng Zong ◽  
Tae Kim ◽  
Seong-Gi Kim

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhenghui Hu ◽  
Pengyu Ni ◽  
Qun Wan ◽  
Yan Zhang ◽  
Pengcheng Shi ◽  
...  

2003 ◽  
Vol 94 (5) ◽  
pp. 1802-1805 ◽  
Author(s):  
Stephan J. Schreiber ◽  
Frank Lürtzing ◽  
Rainer Götze ◽  
Florian Doepp ◽  
Randolf Klingebiel ◽  
...  

Cerebral venous drainage in humans is thought to be ensured mainly via the internal jugular veins (IJVs). However, anatomic, angiographic, and ultrasound studies suggest that the vertebral venous system serves as an important alternative drainage route. We assessed venous blood volume flow in vertebral veins (VVs) and IJVs of 12 healthy volunteers using duplex ultrasound. Measurements were performed at rest and during a transient bilateral IJV and a circular neck compression. Total venous blood volume flow at rest was 766 ± 226 ml/min (IJVs: 720 ± 232, VVs: 47 ± 33 ml/min). During bilateral IJV compression, VV flow increased to 128 ± 64 ml/min. Circular neck compression, causing an additional deep cervical vein obstruction, led to a further rise in VV volume flow (186 ± 70 ml/min). As the observed flow increase did not compensate for IJV flow cessation, other parts of the vertebral venous system, like the intraspinal epidural veins and the deep cervical veins, have to be considered as additional alternative drainage pathways.


NeuroImage ◽  
2012 ◽  
Vol 59 (4) ◽  
pp. 3266-3274 ◽  
Author(s):  
N.P. Blockley ◽  
I.D. Driver ◽  
J.A. Fisher ◽  
S.T. Francis ◽  
P.A. Gowland

2020 ◽  
Vol 86 (1) ◽  
pp. 87-93
Author(s):  
K.G. Mykhnevych ◽  
O.V. Kudinova ◽  
S.A. Lutsik

The state of circulatory energy in blood loss has been studied in 44 patients with spleen injury. Kinetic (final diastolic and systolic volumes of the left ventricle, heart rate), dynamic (effective arterial and central venous pressure, total peripheral resistance), hemic (oxygen content in arterial and venous blood) parameters of blood circulation, as well as the level of lactate reflecting the degree of hypoxia were studied. The energy indicators of blood circulation were determined: the power consumed by tissues, the oxygen reserve (reflecting the correspondence of the oxygen consumed by tissues to their needs) and the integral energy indicator - circulatory reserve. It has been determined that with an increase in blood loss, the energy indicators of blood circulation decrease: the power consumed by tissues decrease to (48.0±6.1); (41.1±8.7) and (23.5±9.3) mW/m2, the oxygen reserve decrease to (0.43±0.04); (0.37±0.05) and(0.27+0.07), the circulatory reserve decrease to (229+93); (180±41) and (47±25) mW/m2 respectively at blood loss 20 %, 30 % and 40 % of blood volume. Apparently 20 % blood loss is the maximum amount of blood loss in relation to compensatory possibilities of autoregulation of blood circulation. 30 % blood loss causes more strain on the compensatory mechanisms, at 40 % blood loss the possibility of autoregulation is exhausted. All patients with blood loss up to 20 and up to 30 % of the blood volume survived in the future, with 40 % blood loss 30 % of patients could not be saved. In all deceased patients the circulatory reserve was below 50 mW/m2. It has been determined that a decrease in the circulatory reserve to 100 mW/m2 or lower is a serious threat to life and requires great intensive therapy for blood loss, the level of the circulatory reserve of 50 mW/m2 is not compatible with life, that is, it corresponds to irreversible hemorrhagic shock. Keywords: blood loss, hypovolemia, circulatory energy, blood flow power, oxygen reserve, circulatory reserve.


2018 ◽  
Vol 167 ◽  
pp. 11-16 ◽  
Author(s):  
Katsuhiro Mizutani ◽  
Masahiro Toda ◽  
Yumi Yajima ◽  
Takenori Akiyama ◽  
Hirokazu Fujiwara ◽  
...  

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