A new method for continuous measuring of respiratory quotient in a computer-assisted working heart preparation

1983 ◽  
Vol 78 (1) ◽  
pp. 1-7 ◽  
Author(s):  
J. F. Hütter ◽  
H. M. Piper ◽  
P. G. Spieckermann
Keyword(s):  
Respiratory Quotient ◽  
New Method ◽  
Computer Assisted ◽  
Heart Preparation ◽  
Continuous Measuring ◽  
Working Heart

Microcomputer acquisition and analysis system for the isolated working heart preparation

1983 ◽  
Vol 10 (1) ◽  
pp. 65-73 ◽  
Author(s):  
David P. Harris ◽  
M.Lynne Marriott ◽  
John H. McNeill
Keyword(s):  
Heart Preparation ◽  
Analysis System ◽  
Working Heart

scholarly journals Vasoactivity of adenosine in the trout (Oncorhynchus mykiss) coronary system: involvement of nitric oxide and interaction with noradrenaline

1998 ◽  
Vol 201 (22) ◽  
pp. 3075-3083 ◽  
Author(s):  
T Mustafa ◽  
C Agnisola
Keyword(s):  
Nitric Oxide ◽  
Constant Pressure ◽  
Constant Flow ◽  
Nitric Oxide Synthase Inhibitor ◽  
Heart Preparation ◽  
Synthase Inhibitor ◽  
Coronary Endothelium ◽  
Oxide Synthase ◽  
Working Heart

A vasoconstrictory response to adenosine has been reported in coronary rings from fish. Since the reactivity of the large coronary arteries and the microcirculation may differ, the present study was undertaken to determine the role of adenosine in the intact coronary system of trout under constant pressure or flow using an isolated and non-working heart preparation. The involvement of nitric oxide (NO) and the interaction with noradrenaline were also studied. At 10(-9) to 10(-8 )mol l-1, adenosine caused a vasoconstrictory response, whereas between 10(-7) and 10(-5 )mol l-1 the response was predominantly vasodilative. Theophylline abolished both these responses to adenosine. The vasodilation induced by adenosine (at 10(-5 )mol l-1) was significantly reduced when the preparation was perfused under constant-flow than rather under constant-pressure conditions. The nitric oxide synthase inhibitor N-nitro-l-arginine (l-NA, 10(-4 )mol l-1) partially reduced the vasodilation induced by adenosine (at 10(-5 )mol l-1) under constant-pressure but not under constant-flow conditions. Perfusion of the intact coronary system with l-arginine or with adenosine significantly increased the rate of nitrite (NO2-) release, while perfusion with l-NA or theophylline reduced NO2- release. Chemical denudation of the coronary endothelium by CHAPS resulted in the loss of both the l-arginine- and adenosine-mediated vasodilation and the l-arginine-induced increase in the rate of NO2- release. Adenosine (10(-5 )mol l-1) offset and overrode the vasoconstriction induced by 10(-7 )mol l-1 noradrenaline. l-NA inhibited only the adenosine-induced vasodilation but not the ability to offset noradrenaline vasoconstriction, excluding the involvement of NO in the interaction between adenosine and noradrenaline.

A new method and a clinical case for computer assisted dental implantology

2002 ◽  
pp. 953-958 ◽  
Author(s):  
François Goulette ◽  
Julien Dutreuil ◽  
Claude Laurgeau ◽  
Jaime Clavero Zoreda ◽  
Stefan Lundgren
Keyword(s):  
Clinical Case ◽  
New Method ◽  
Computer Assisted

A new model for the research into rhythmic contraction activity of cardiomyocytes in vitro

1995 ◽  
Vol 73 (7-8) ◽  
pp. 431-439 ◽  
Author(s):  
Włodzimierz Korohoda ◽  
Anna Jurkiewicz ◽  
Izabela Figiel ◽  
Jarosław Czyż
Keyword(s):  
Image Analysis ◽  
Quantitative Research ◽  
Contractile Activity ◽  
Glass Fibers ◽  
Computer Assisted ◽  
Heart Cells ◽  
Heart Preparation ◽  
Chick Embryo Heart ◽  
Embryo Heart

Heart cells continue to contract rhythmically after isolation and in culture in vitro. We describe a model of heart preparation in vitro that permits quantitative research on the frequency of contractions of cardiomyocytes. The chick embryo heart explants placed on a network of elastic glass fibers continued beating for months, recorded and analyzed with the methods of computer-assisted image analysis. The efficacy of this experimental model for the screening of effects of various agents on the frequency of contractions was examined by following the effects of nifedipine, caffeine, ethanol, and benzamide. The reversibility of the effects and the reproducibility of results were demonstrated quantitatively. The significance of a mechanical elastic load provided by glass fibers for the preservation of long-lasting contractile activity of cardiomyocytes is discussed and the common occurrence of oscillatory contraction processes in various eucaryotic cells is noted.Key words: heart, contractility, benzamide, caffeine, nifedipine, ethanol, image analysis, cardiomyocytes.

Effects of triiodothyronine and carnitine therapy on myocardial dysfunction in diabetic rats

1986 ◽  
Vol 64 (6) ◽  
pp. 669-672 ◽  
Author(s):  
Arun G. Tahiliani ◽  
John H. McNeill
Keyword(s):  
Left Atrial ◽  
Calcium Uptake ◽  
Myocardial Dysfunction ◽  
Diabetic Rats ◽  
Myosin Atpase ◽  
Myocardial Performance ◽  
Cardiac Myosin ◽  
Heart Preparation ◽  
Streptozotocin Diabetic Rats ◽  
Working Heart

Streptozotocin-diabetic rats were treated with a combination of triiodothyronine and carnitine for 6 weeks. These compounds were used as they are known to correct the diabetes-induced depression of cardiac myosin ATPase and sarcoplasmic reticular (SR) calcium uptake, respectively. Myocardial performance, which was assessed using the working heart preparation, revealed a depression of function in untreated diabetics when compared with controls at most left atrial filling pressures. Hearts from diabetic rats treated with the combination exhibited depression at only the higher filling pressures as compared with untreated or treated controls. The results suggest that functional alterations occurring as a result of diabetes cannot be accounted for by the depression of cardiac myosin ATPase and SR calcium uptake alone.

scholarly journals Automated identification of borrowings in multilingual wordlists

2021 ◽  
Vol 1 ◽  
pp. 79
Author(s):  
Johann-Mattis List ◽  
Robert Forkel
Keyword(s):  
Language Evolution ◽  
East Asian ◽  
New Method ◽  
Computer Assisted ◽  
Automated Identification ◽  
Lexical Borrowing ◽  
Contact Areas ◽  
Asian Languages ◽  
Multiple Languages

Although lexical borrowing is an important aspect of language evolution, there have been few attempts to automate the identification of borrowings in lexical datasets. Moreover, none of the solutions which have been proposed so far identify borrowings across multiple languages. This study proposes a new method for the task and tests it on a newly compiled large comparative dataset of 48 South-East Asian languages. The method yields very promising results, while it is conceptually straightforward and easy to apply. This makes the approach a perfect candidate for computer-assisted exploratory studies on lexical borrowing in contact areas.

A New Method in Computer-Assisted Imaging in Neuroanatomy

1985 ◽  
Vol 123 (4) ◽  
pp. 240-246 ◽  
Author(s):  
Graf V. Keyserlingk ◽  
K. Niemann ◽  
J. Wasel ◽  
J. Reinold ◽  
K. Poeck
Keyword(s):  
New Method ◽  
Computer Assisted
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