Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model

1993 ◽  
Vol 39 (S1) ◽  
pp. C169-C173 ◽  
Author(s):  
S. Kuchera ◽  
H. Barth ◽  
P. Jacobson ◽  
A. Metz ◽  
C. Schaechtele ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Ear Edema ◽  
Kinase C ◽  
Edema Model ◽  
Mouse Ear ◽  
Protein Kinase C Inhibitor ◽  
Anti Inflammatory ◽  
Mouse Ear Edema

scholarly journals Retrofractamide C Derived from Piper longum Alleviates Xylene-Induced Mouse Ear Edema and Inhibits Phosphorylation of ERK and NF-κB in LPS-Induced J774A.1

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4058 ◽  
Author(s):  
Hyung Jin Lim ◽  
Seon Gyeong Bak ◽  
Eun Jae Park ◽  
Sae-Kwang Ku ◽  
Soyoung Lee ◽  
...  
Keyword(s):  
Biological Activities ◽  
Edema Formation ◽  
Ear Edema ◽  
Extracellular Signal ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Mouse Ear Edema ◽  
Inflammatory Effect

Many studies have reported the biological activities of retrofractamide C (RAC). However, few studies have investigated the anti-inflammatory effect of RAC. In the present study, we investigated the anti-inflammatory effect of RAC using lipopolysaccharide (LPS)-induced J774A.1 cells and a xylene-induced mouse ear edema model. Treatment with RAC decreased LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) secretion and inducible NO synthase (iNOS) and cyclooxygenase 2 (COX2) protein expression. It also downregulated the LPS-induced production of interleukin-1β (IL-1β) and interleukin-6 (IL-6) but not tumor necrosis factor α (TNF-α). In the LPS-induced signaling pathway, RAC inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) but not c-Jun N-terminal kinase (JNK) or p38. In a xylene-induced mouse ear edema model, RAC treatment alleviated edema formation and inflammatory cell infiltration. In conclusion, the present study indicates that RAC has the potential to have anti-inflammatory effects and could be a prospective functional food.

scholarly journals Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Wan Mohd Nuzul Hakimi Wan Salleh ◽  
Mohd Fariz Kammil ◽  
Farediah Ahmad ◽  
Hasnah Mohd Sirat
Keyword(s):  
Essential Oil ◽  
Hexane Extract ◽  
Total Phenolic ◽  
Significant Activity ◽  
Ear Edema ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema ◽  
Β Carotene

The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC–MS analysis of the essential oil resulted in the identification of 64 components, accounting for 89.2% of the total. The major components were caryophyllene oxide (20.3%) and α-cubebene (10.4%). The antioxidant activity was evaluated by β-carotene/linoleic acid bleaching, DPPH radical scavenging and total phenolic content. In the β-carotene assay, the n-hexane extract showed the highest inhibition activity with 42.7%, while the oil gave 91.3%. The essential oil and extracts were tested for anti-inflammatory activity by using the TPA-induced mouse ear edema model and lipoxygenase assays. The essential oil exhibited significant activity in both models as an anti-inflammatory agent. The n-hexane extract showed strong activity with inhibition of 85.9% in the TPA-induced mouse ear edema model, while the chloroform extract showed the highest activity with 94.2% in the lipoxygenase assay.

Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor

1992 ◽  
Vol 37 (1-2) ◽  
pp. 85-89 ◽  
Author(s):  
M. J. Mulqueen ◽  
D. Bradshaw ◽  
P. D. Davis ◽  
L. Elliott ◽  
T. A. Griffiths ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Inflammatory Activity ◽  
Kinase C ◽  
Protein Kinase C Inhibitor ◽  
Anti Inflammatory

Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor

2010 ◽  
Vol 382 (3) ◽  
pp. 193-199 ◽  
Author(s):  
Rita Selvatici ◽  
Francesco Congestrì ◽  
Giuliano Marzola ◽  
Remo Guerrini ◽  
Anna Siniscalchi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Analgesic Effects ◽  
Kinase C ◽  
Endogenous Protein ◽  
Protein Kinase C Inhibitor ◽  
Anti Inflammatory

Oral anti-inflammatory activity of a potent, selective, protein kinase C inhibitor

1991 ◽  
Vol 13 (6) ◽  
pp. 749 ◽  
Author(s):  
D. Bradshaw ◽  
M. Mulqueen ◽  
E. Lewis ◽  
J. Bishop ◽  
A. Greenham ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Inflammatory Activity ◽  
Kinase C ◽  
Protein Kinase C Inhibitor ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory Activity of Piper Magnibaccum (Piperaceae)

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Emrizal ◽  
Farediah Ahmad ◽  
Hasnah M. Sirat ◽  
Fadzureena Jamaludin ◽  
Nik Musa'adah Mustapha ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Significant Activity ◽  
Inhibition Assay ◽  
Ear Edema ◽  
Lipoxygenase Inhibition ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema

Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [β-sitosterol, N-isobutyl-(2 E,4 E)-tetradecadienamide, linoleic acid, 13-(4′, 5′-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2 E,4 E)-tetradecadienamide showed significant activity, with an IE % value of 70.2 + 5.4 in the TPA-induced mouse ear edema model and 87.2 + 0.11 in the in vitro quantitative lipoxygenase inhibition assay.

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