Evaluation of Anti-Inflammatory Activity of Water Extract From Sterilized Citrus unshiu Macrow Peels in 12-0-Tetradecanoylphorbol acetate (TPA)-Induced Mouse Ear Edema Model

2019 ◽  
Vol 24 (3) ◽  
pp. 186-191
Author(s):  
Soo Yeon Park ◽  
Eui Jeong Han ◽  
Min Ju Kim ◽  
Chan-Bum Ahn ◽  
Kyungsook Jung ◽  
...  
Keyword(s):  
Water Extract ◽  
Inflammatory Activity ◽  
Citrus Unshiu ◽  
Ear Edema ◽  
Tetradecanoylphorbol Acetate ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema

scholarly journals Anti-inflammatory Activity of Piper Magnibaccum (Piperaceae)

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Emrizal ◽  
Farediah Ahmad ◽  
Hasnah M. Sirat ◽  
Fadzureena Jamaludin ◽  
Nik Musa'adah Mustapha ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Significant Activity ◽  
Inhibition Assay ◽  
Ear Edema ◽  
Lipoxygenase Inhibition ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema

Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [β-sitosterol, N-isobutyl-(2 E,4 E)-tetradecadienamide, linoleic acid, 13-(4′, 5′-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2 E,4 E)-tetradecadienamide showed significant activity, with an IE % value of 70.2 + 5.4 in the TPA-induced mouse ear edema model and 87.2 + 0.11 in the in vitro quantitative lipoxygenase inhibition assay.

scholarly journals Anti-Inflammatory Activity of Cnidoscolus aconitifolius (Mill.) Ethyl Acetate Extract on Croton Oil-Induced Mouse Ear Edema

2021 ◽  
Vol 11 (20) ◽  
pp. 9697
Author(s):  
Eduardo Padilla-Camberos ◽  
Omar Ricardo Torres-Gonzalez ◽  
Ivan Moises Sanchez-Hernandez ◽  
Nestor Emmanuel Diaz-Martinez ◽  
Oscar Rene Hernandez-Perez ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Inflammatory Activity ◽  
Therapeutic Effects ◽  
Ear Edema ◽  
Croton Oil ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema

Nowadays, there is a growing interest in the development of medicinal plant-based therapies to diminish the ravages of the inflammatory process related to diseases and tissue damage. Most therapeutic effects of these traditional medicinal plants are owed to their phenolic and antioxidant properties. C. aconitifolius is a traditional medicinal plant in Mexico. Previous characterization reports have stated its high nutritional and antioxidant components. The present study aimed to better understand the biological activity of C. aconitifolius in inflammation response. We developed an ethyl acetate extract of this plant to evaluate its anti-inflammatory capacity and its flavonoid content. The topical anti-inflammatory effect of the ethyl acetate extract of C. aconitifolius was determined by the croton oil-induced mouse ear edema test, while flavonoid detection and concentration were determined by thin layer chromatography and the aluminum chloride colorimetric assay, respectively. Topical application of the extract showed significant inhibition of the induced-ear edema (23.52 and 49.41% for 25 and 50 mg/kg dose, respectively). The extract also exhibited the presence of flavonoids. The finding of the anti-inflammatory activity exerted by the C. aconitifolius and the identification of its active principles may suggest and support its use for inflammation treatment.

scholarly journals Retrofractamide C Derived from Piper longum Alleviates Xylene-Induced Mouse Ear Edema and Inhibits Phosphorylation of ERK and NF-κB in LPS-Induced J774A.1

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4058 ◽  
Author(s):  
Hyung Jin Lim ◽  
Seon Gyeong Bak ◽  
Eun Jae Park ◽  
Sae-Kwang Ku ◽  
Soyoung Lee ◽  
...  
Keyword(s):  
Biological Activities ◽  
Edema Formation ◽  
Ear Edema ◽  
Extracellular Signal ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Mouse Ear Edema ◽  
Inflammatory Effect

Many studies have reported the biological activities of retrofractamide C (RAC). However, few studies have investigated the anti-inflammatory effect of RAC. In the present study, we investigated the anti-inflammatory effect of RAC using lipopolysaccharide (LPS)-induced J774A.1 cells and a xylene-induced mouse ear edema model. Treatment with RAC decreased LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) secretion and inducible NO synthase (iNOS) and cyclooxygenase 2 (COX2) protein expression. It also downregulated the LPS-induced production of interleukin-1β (IL-1β) and interleukin-6 (IL-6) but not tumor necrosis factor α (TNF-α). In the LPS-induced signaling pathway, RAC inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) but not c-Jun N-terminal kinase (JNK) or p38. In a xylene-induced mouse ear edema model, RAC treatment alleviated edema formation and inflammatory cell infiltration. In conclusion, the present study indicates that RAC has the potential to have anti-inflammatory effects and could be a prospective functional food.

Anti-Inflammatory Activity of Dichloromethane Fraction from Katsuwonus pelamis Heart in LPS-Induced RAW 264.7 Cells and Mouse Ear Edema

2017 ◽  
Vol 45 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Min-Ji Kim ◽  
Nan-Young Bae ◽  
Hyeun-Deok Choi ◽  
Koth-Bong-Woo-Ri Kim ◽  
Sun-Hee Park ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Katsuwonus Pelamis ◽  
Ear Edema ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema

scholarly journals Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Wan Mohd Nuzul Hakimi Wan Salleh ◽  
Mohd Fariz Kammil ◽  
Farediah Ahmad ◽  
Hasnah Mohd Sirat
Keyword(s):  
Essential Oil ◽  
Hexane Extract ◽  
Total Phenolic ◽  
Significant Activity ◽  
Ear Edema ◽  
Edema Model ◽  
Mouse Ear ◽  
Anti Inflammatory ◽  
Mouse Ear Edema ◽  
Β Carotene

The chemical composition of the essential oil and antioxidant and anti-inflammatory activities of the extracts from Piper miniatum were determined. GC and GC–MS analysis of the essential oil resulted in the identification of 64 components, accounting for 89.2% of the total. The major components were caryophyllene oxide (20.3%) and α-cubebene (10.4%). The antioxidant activity was evaluated by β-carotene/linoleic acid bleaching, DPPH radical scavenging and total phenolic content. In the β-carotene assay, the n-hexane extract showed the highest inhibition activity with 42.7%, while the oil gave 91.3%. The essential oil and extracts were tested for anti-inflammatory activity by using the TPA-induced mouse ear edema model and lipoxygenase assays. The essential oil exhibited significant activity in both models as an anti-inflammatory agent. The n-hexane extract showed strong activity with inhibition of 85.9% in the TPA-induced mouse ear edema model, while the chloroform extract showed the highest activity with 94.2% in the lipoxygenase assay.

scholarly journals Topical Anti-Inflammatory Activity of Oil fromTropidurus hispidus(Spix, 1825)

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Israel J. M. Santos ◽  
Gerlânia O. Leite ◽  
José Galberto M. Costa ◽  
Romulo R. N. Alves ◽  
Adriana R. Campos ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Ventral Region ◽  
Ear Edema ◽  
Medicinal Use ◽  
Mouse Ear ◽  
Experimental Inflammation ◽  
Anti Inflammatory ◽  
Model Oil ◽  
The Right ◽  
Mouse Ear Edema

Tropidurus hispidushas been used in traditional medicine in several regions of Northeastern Region of Brazil. Its medicinal use involves the treatment of diseases such as warts, sore throat, tonsillitis, chicken pox, varicella, measles, asthma, alcoholism, and dermatomycosis. The present study evaluated the topical anti-inflammatory activity ofTropidurus hispidusfat in treating ear edema in an animal model. Oil fromT. hispidus(OTH) was evaluated on its effect against experimental inflammation in mice. OTH was extracted from body fat located in the ventral region ofTropidurus hispidususing hexane as a solvent. We used the model of mouse ear edema induced by phlogistic agents, croton oil (single and multiple applications), arachidonic acid, phenol, capsaicin, and histamine, applied into the right ears of animals pretreated with acetone (control), dexamethasone, or OTH. OTH inhibited the dermatitis induced by all noxious agents, except capsaicin. This effect may be related to the fatty acids present in OTH.

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