Didanosine, a new antiretroviral drug

1992 ◽  
Vol 14 (5) ◽  
pp. 297-304 ◽  
Author(s):  
R. M. E. Franssen ◽  
P. L. Meenhorst ◽  
C. H. W. Koks ◽  
J. H. Beijnen
Keyword(s):  
Antiretroviral Drug

scholarly journals Multiple Mutations in the Human Immunodeficiency Virus Protease Gene Are Responsible for Decreased Susceptibility to Protease Inhibitors

1995 ◽  
Vol 6 (2) ◽  
pp. 80-88 ◽  
Author(s):  
R. W. King ◽  
S. Garber ◽  
D. L. Winslow ◽  
C. Reid ◽  
L. T. Bacheler ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Protease Inhibitors ◽  
Clinical Isolate ◽  
Protease Gene ◽  
Human Immunodeficiency Virus Protease ◽  
Fold Reduction ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Hiv 1

The protease (PR) of the human immunodeficiency virus (HIV) is essential for replication of the virus, and accordingly has become an attractive target for the development of an antiretroviral drug. We have previously reported that passage of HIV-1 in the presence of increasing concentrations of the C-2 symmetrical, linear diol P9941 resulted in the isolation of virus with a valine-to-alanine change at position 82 (V82A) of the PR, and reduced sensitivity to certain PR inhibitors. In this study, we passaged four different variants of HIV-1 in increasing concentrations of XM323, and isolated variants with reduced sensitivity to inhibitors of PR. Twenty-three passages of HIV-1 (RF) in the presence of XM323 resulted in a variant that exhibited an approximately 100-fold reduction in susceptibility to XM323 and that contained V82F and I84V changes. When two other viruses, HIV-1 (RF41D2) and HIV-1(RF41E4), previously derived from HIV-1 (RF) by passage in the presence of P9941, were passaged in the presence of XM323, variants with V82A/L97V and M46L/V82A/L97V changes, respectively, were obtained. The M46L/V82A/L97V variant showed a 6-fold reduction in sensitivity to XM323, whereas the susceptibility of the V82A/L97V mutant remained unchanged. Seventeen passages of a clinical isolate of HIV-1, HIV-1 (Pat.E), in the presence of XM323 produced a V82F/L97V mutant with an approximately 9-fold reduction in sensitivity to XM323.

Salvage Treatment with Lopinavir/Ritonavir (Kaletra) in HIV-Infected Patients Failing All Current Antiretroviral Drug Families

2002 ◽  
Vol 3 (4) ◽  
pp. 304-309 ◽  
Author(s):  
Mendoza Carmen de ◽  
Martín-Carbonero Luz ◽  
Barreiro Pablo ◽  
Diaz Beatriz ◽  
Valencia Eulalia ◽  
...  
Keyword(s):  
Salvage Treatment ◽  
Antiretroviral Drug

Antiretroviral drug interactions

1995 ◽  
Vol 5 (2) ◽  
pp. 73-83 ◽  
Author(s):  
Edward P. Acosta ◽  
Courtney V. Fletcher
Keyword(s):  
Drug Interactions ◽  
Antiretroviral Drug

Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry

2011 ◽  
Vol 46 (3) ◽  
pp. 282-289 ◽  
Author(s):  
Roland J. W. Meesters ◽  
Jeroen J. A. van Kampen ◽  
Rachel D. Scheuer ◽  
Marchina E. van der Ende ◽  
Rob A. Gruters ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Isotope Dilution ◽  
Tandem Mass ◽  
Triple Quadrupole ◽  
Antiretroviral Drug
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