Gas chromatographic method for the determination of residues of chlordanes and related compounds in fish and shellfish

1980 ◽  
Vol 25 (1) ◽  
pp. 305-312 ◽  
Author(s):  
Tomoyuki Miyazaki ◽  
Kazuyuki Akiyama ◽  
Sciji Kaneko ◽  
Shozo Horii ◽  
Tatsunori Yamagishi ◽  
...  
Keyword(s):  
Chromatographic Method ◽  
Gas Chromatographic Method ◽  
Fish And Shellfish ◽  
Related Compounds

Methods for Assay, Related Substances, and Organic Volatile Impurities in Triazolam Raw Materials and Formulations

1991 ◽  
Vol 74 (3) ◽  
pp. 456-460
Author(s):  
Normand Beaulieu ◽  
Terry D Cyr ◽  
Susan J Graham ◽  
Robert C Lawrence ◽  
Roger W Sears ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Chromatographic Method ◽  
Raw Materials ◽  
Methyl Ethyl ◽  
Related Substances ◽  
Gas Chromatographic Method ◽  
Liquid Chromatographic ◽  
Related Compounds ◽  
Volatile Impurities

Abstract Liquid chromatographic methods have been developed for determination of triazolam and related compounds in drug raw materials and tablets. The methods resolve 9 available related compounds from the drug with quantitation limits of 0.1 % or less. Eight raw materials and 16 formulations were examined for related compounds. Total impurities in raw materials ranged up to 0.6% and up to 1% in formulations, not including a compound in some tablets that is believed to be excipient related. Assay values were between 99.9 and 101.3% for raw materials and between 89.4 and 105.5% for tablets. A gas chromatographic method was developed for organic volatile Impurities in drug raw materials. The major solvents found were methyl ethyl ketone (100-750 ppm), ethyl acetate (510 ppm), and n-propanol (80-300 ppm), with a trace of benzene (<30 ppm) in several samples.

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