Reduced pancreatic insulin release and reduced peripheral insulin sensitivity contribute to hyperglycaemia in cystic fibrosis

1995 ◽  
Vol 154 (5) ◽  
pp. 356-361 ◽  
Author(s):  
R. W. Holl ◽  
E. Heinze ◽  
A. Wolf ◽  
M. Rank ◽  
W. M. Teller
Keyword(s):  
Cystic Fibrosis ◽  
Insulin Sensitivity ◽  
Insulin Release ◽  
Peripheral Insulin Sensitivity ◽  
Pancreatic Insulin

Reduced pancreatic insulin release and reduced peripheral insulin sensitivity contribute to hyperglycaemia in cystic fibrosis

1995 ◽  
Vol 154 (5) ◽  
pp. 356-361 ◽  
Author(s):  
R. W. Holl ◽  
E. Heinze ◽  
A. Wolf ◽  
M. Rank ◽  
W. M. Teller
Keyword(s):  
Cystic Fibrosis ◽  
Insulin Sensitivity ◽  
Insulin Release ◽  
Peripheral Insulin Sensitivity ◽  
Pancreatic Insulin

Insulin release and pancreatic insulin is reduced in young prediabetic BB rats

1986 ◽  
Vol 112 (3) ◽  
pp. 367-371 ◽  
Author(s):  
Annette Svenningsen ◽  
Thomas Dyrberg ◽  
Helle Markholst ◽  
Christian Binder ◽  
Åke Lernmark
Keyword(s):  
Insulin Release ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Content ◽  
Dependent Diabetes Mellitus ◽  
Clinical Onset ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content ◽  
Bb Rats ◽  
Insulin Dependent ◽  
The Mean

Abstract. The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82–84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P <0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20–40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.

scholarly journals Natural history of glucose tolerance, beta-cell function and peripheral insulin sensitivity in cystic fibrosis patients with fasting euglycemia

2003 ◽  
Vol 149 (1) ◽  
pp. 53-59 ◽  
Author(s):  
F Lombardo ◽  
F De Luca ◽  
M Rosano ◽  
C Sferlazzas ◽  
C Lucanto ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Insulin Sensitivity ◽  
Natural History ◽  
Glucose Tolerance ◽  
Pancreatic Beta Cells ◽  
Cell Function ◽  
Glucose Levels ◽  
Peripheral Insulin Resistance ◽  
History Of ◽  
Over Time

OBJECTIVE: The loss of pancreatic beta-cells is thought to be one of the principal causes of diabetes mellitus (DM) in cystic fibrosis (CF), but the role of peripheral insulin resistance (IR) in the pathogenesis of DM in CF remains unclear. The aim of this study was to evaluate whether eventual changes of glucose tolerance (GT) over time were associated with modifications of insulin secretion or sensitivity. METHODS: Plasma glucose and insulin responses to an oral GT test (OGTT) were investigated and reinvestigated 13 Years later in 14 CF patients with initial and persistent fasting euglycemia and no history of insulin treatment. Insulin sensitivity (IS) at both tests was assessed on the basis of insulin and glucose levels both in the fasting state and during OGTTs. RESULTS: From the 1st to the 2nd OGTT: (a) the prevalence of DM responses significantly increased; (b) the areas beneath the respective glucose and insulin curves significantly increased and decreased respectively; (c) IR and IS indices decreased and increased respectively, even in the patients who developed DM; (d) pulmonary function significantly worsened in the entire series, especially in the patients who developed DM. CONCLUSIONS: (i) the natural history of glyco-metabolic status in CF is characterized by deteriorating GT over time; (ii) insulinopenia plays a prominent role in the pathogenesis of GT worsening; (iii) IR does not play any significant part in the pathogenesis of DM development; (iv) deterioration of lung function tests is more severe in the subjects who develop DM over time.

scholarly journals Overfeeding Dairy Cattle during Late-Pregnancy Alters Hepatic PPARα-Regulated Pathways Including Hepatokines: Impact on Metabolism and Peripheral Insulin Sensitivity

2014 ◽  
Vol 8 ◽  
pp. GRSB.S14116 ◽  
Author(s):  
M. Jawad Khan ◽  
Carolina B. Jacometo ◽  
Daniel E. Graugnard ◽  
Marcio N. Corrêa ◽  
Eduardo Schmitt ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Dairy Cattle ◽  
Late Pregnancy ◽  
Peripheral Insulin Sensitivity

scholarly journals Early Enhancements of Hepatic and Later of Peripheral Insulin Sensitivity Combined With Increased Postprandial Insulin Secretion Contribute to Improved Glycemic Control After Roux-en-Y Gastric Bypass

Diabetes ◽  
2013 ◽  
Vol 63 (5) ◽  
pp. 1725-1737 ◽  
Author(s):  
Kirstine N. Bojsen-Møller ◽  
Carsten Dirksen ◽  
Nils B. Jørgensen ◽  
Siv H. Jacobsen ◽  
Annette K. Serup ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Glycemic Control ◽  
Peripheral Insulin Sensitivity ◽  
Postprandial Insulin

Pubertal changes in HOMA and QUICKI: relationship to hepatic and peripheral insulin sensitivity

2004 ◽  
Vol 5 (3) ◽  
pp. 122-125 ◽  
Author(s):  
Robert P. Hoffman ◽  
Paolo Vicini ◽  
Claudio Cobelli
Keyword(s):  
Insulin Sensitivity ◽  
Peripheral Insulin Sensitivity

scholarly journals Impaired peripheral insulin sensitivity in non-obese Japanese patients with type 2 diabetes mellitus and fatty liver

2017 ◽  
Vol 9 (3) ◽  
pp. 529-535 ◽  
Author(s):  
Yasuhiko Furukawa ◽  
Yoshifumi Tamura ◽  
Kageumi Takeno ◽  
Takashi Funayama ◽  
Hideyoshi Kaga ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Japanese Patients ◽  
Peripheral Insulin Sensitivity

The Decline in Pancreatic Insulin Release During Hemorragic Shock in the Baboon

1973 ◽  
pp. 199-207
Author(s):  
G. S. Moss ◽  
G. Cerchio ◽  
D. C. Siegel ◽  
P. C. Reed ◽  
A. Cochin ◽  
...  
Keyword(s):  
Insulin Release ◽  
Pancreatic Insulin
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