Pharmacokinetics of pantoprazole following single intravenous and oral administration to healthy male subjects

1993 ◽  
Vol 44 (6) ◽  
pp. 575-578 ◽  
Author(s):  
M. A. Pue ◽  
J. Laroche ◽  
I. Meineke ◽  
C. de Mey
Keyword(s):  
Oral Administration ◽  
Healthy Male ◽  
Intravenous And Oral Administration ◽  
Male Subjects

scholarly journals Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects

2017 ◽  
Vol 73 (1) ◽  
pp. 183-190 ◽  
Author(s):  
Yewon Choi ◽  
Sang Won Lee ◽  
Anhye Kim ◽  
Kyungho Jang ◽  
Heesook Nam ◽  
...  
Keyword(s):  
Oral Administration ◽  
Healthy Male ◽  
Male Subjects

Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects

2006 ◽  
Vol 62 (5) ◽  
pp. 335-341 ◽  
Author(s):  
Daniel Röshammar ◽  
Trinh Ngoc Hai ◽  
Sofia Friberg Hietala ◽  
Nguyen Van Huong ◽  
Michael Ashton
Keyword(s):  
Oral Administration ◽  
Healthy Male ◽  
Male Subjects

Simultaneous Measurement of Cortisol in Serum and Saliva After Different Forms of Cortisol Administration

1992 ◽  
Vol 38 (8) ◽  
pp. 1491-1494 ◽  
Author(s):  
S Tunn ◽  
H Möllmann ◽  
J Barth ◽  
H Derendorf ◽  
M Krieg
Keyword(s):  
Oral Administration ◽  
Binding Capacity ◽  
Serum Cortisol ◽  
Rectal Administration ◽  
Biologically Active ◽  
Healthy Male ◽  
Hormone Substitution ◽  
Corticosteroid Binding Globulin ◽  
Intravenous And Oral Administration ◽  
Acetate Form

Abstract To prove the clinical usefulness of cortisol measurements in saliva for the exact assessment of a patient's corticoid status under therapeutic hormone substitution, we measured simultaneously total cortisol in serum and non-protein-bound cortisol in saliva after administration of different forms of hydrocortisone (cortisol) in eight cortisol-suppressed, healthy male volunteers. The intravenous and oral administration of 20 mg of cortisol exceeds the binding capacity of the corticosteroid-binding globulin (CBG), leading to an increase of the ratio between salivary and serum cortisol at the higher cortisol concentrations in blood. After rectal administration of 100 mg of cortisol acetate, the serum cortisol concentration does not exceed the binding capacity of CBG, so the ratio between salivary and serum cortisol remains nearly constant. However, this ratio was higher after rectal administration than after intravenous and oral administration, probably because of weaker binding of the acetate form of cortisol to CBG. Thus, the salivary measurement of the non-protein-bound (i.e., biologically active) cortisol offers a convenient way to monitor the effectiveness of various forms of systemic corticoid substitution.

scholarly journals Pharmacokinetics, metabolism and excretion of [14C]-lenalidomide following oral administration in healthy male subjects

2011 ◽  
Vol 69 (3) ◽  
pp. 789-797 ◽  
Author(s):  
Nianhang Chen ◽  
Lian Wen ◽  
Henry Lau ◽  
Sekhar Surapaneni ◽  
Gondi Kumar
Keyword(s):  
Oral Administration ◽  
Healthy Male ◽  
Male Subjects

Comparison of the Appearance of Radiolabelled Vitamin D3 and 25-Hydroxy-Vitamin D3 in the Chylomicron Fraction of Plasma after Oral Administration in Man

1981 ◽  
Vol 60 (2) ◽  
pp. 241-243 ◽  
Author(s):  
Juliet E. Compston ◽  
Anne L. Merrett ◽  
F. G. Hammett ◽  
P. Magill
Keyword(s):  
Vitamin D ◽  
Oral Administration ◽  
Intestinal Absorption ◽  
Bile Acids ◽  
Vitamin D3 ◽  
Total Plasma ◽  
Healthy Male ◽  
25 Hydroxy Vitamin D ◽  
Male Subjects

1. The uptake of either orally administered [3H]vitamin D3 or 25-[3H]hydroxy-vitamin D3 into the chylomicron fraction of plasma was studied in 12 healthy male subjects. 2. The amount of [3H]vitamin D3 in the chylomicron fraction expressed as a percentage of the total plasma radioactivity was higher than that of 25-[3H]hydroxy-vitamin D3. 3. It is suggested that the mechanism of intestinal absorption of vitamin D and 25-hydroxy-vitamin D may differ in man, the absorption of 25-hydroxy-vitamin D possibly being less dependent on bile acids.

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