Differences in the neuronal activity of dorsal horn neurons between rats developing and not developing a pain syndrome after sciatic nerve transection

1995 ◽  
Vol 119 (5) ◽  
pp. 452-455
Author(s):  
G. N. Kryzhanovskii ◽  
V. K. Reshetnyak ◽  
M. L. Kukushkin ◽  
V. A. Zinkevich ◽  
V. S. Smirnova
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Neuronal Activity ◽  
Pain Syndrome ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Dorsal Horn Neurons

Electrical activity in the dorsal spinal cord horns and the somatosensory cortex of rats with and without a pain syndrome following sciatic nerve transection

1993 ◽  
Vol 115 (5) ◽  
pp. 495-497
Author(s):  
G. N. Kryzhanovskii ◽  
V. K. Reshetnyak ◽  
M. L. Kukushkin ◽  
V. S. Smirnova ◽  
V. A. Zinkevich
Keyword(s):  
Spinal Cord ◽  
Sciatic Nerve ◽  
Electrical Activity ◽  
Somatosensory Cortex ◽  
Pain Syndrome ◽  
Nerve Transection ◽  
Dorsal Spinal Cord ◽  
Sciatic Nerve Transection ◽  
Dorsal Spinal

Number of synapses increased in the rat spinal dorsal horn after sciatic nerve transection: A stereological study

2011 ◽  
Vol 84 (6) ◽  
pp. 430-433 ◽  
Author(s):  
Jing-Yan Lin ◽  
Bin Peng ◽  
Zheng-Wei Yang ◽  
Su Min
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Nerve Transection ◽  
Sciatic Nerve Transection ◽  
Spinal Dorsal

scholarly journals Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Shih-Tien Hsu ◽  
Chun-Hsu Yao ◽  
Yuan-Man Hsu ◽  
Jia-Horng Lin ◽  
Yung-Hsiang Chen ◽  
...  
Keyword(s):  
Growth Factors ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Nerve Transection ◽  
Cremophor El ◽  
Neuronal Connectivity ◽  
Sciatic Nerve Transection ◽  
Expression Levels ◽  
Nerve Growth Factors

Abstract Recent studies describe taxol as a candidate treatment for promoting central nerve regeneration. However, taxol has serious side effects including peripheral neurotoxicity, and little information is known about the effect of taxol on peripheral nerve regeneration. We investigated the effects of taxol on regeneration in a rat sciatic nerve transection model. Rats were divided into four groups (n = 10): normal saline (i.p.) as the control, Cremophor EL vehicle, and 2 or 6 mg/kg of taxol in the Cremophor EL solution (four times in day-2, 4, 6, and 8), respectively. We evaluated neuronal electrophysiology, animal behaviour, neuronal connectivity, macrophage infiltration, location and expression levels of calcitonin gene-related peptide (CGRP), and expression levels of both nerve growth factors and immunoregulatory factors. In the high-dose taxol group (6 mg/kg), neuronal electrophysiological function was significantly impaired. Licking latencies were significantly changed while motor coordination was unaffected. Neuronal connectivity, macrophage density, and expression levels of CGRP was dramatically reduced. Expression levels of nerve growth factors and immunoregulatory factors was also reduced, while it was increased in the low-dose taxol group (2 mg/kg). These results indicate that taxol can modulate local inflammatory conditions, impair nerve regeneration, and impede recovery of a severe peripheral nerve injury.

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