Neuroimaging of emotional brain circuitry in bipolar disorder

2006 ◽  
Vol 4 (4) ◽  
pp. 159-166
Author(s):  
Natalie Weder ◽  
Lara Chepenik ◽  
Jessica H. Kalmar ◽  
Hilary P. Blumberg
Keyword(s):  
Bipolar Disorder ◽  
Brain Circuitry

scholarly journals Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents

2016 ◽  
Vol 95 (1-2) ◽  
pp. 777-791 ◽  
Author(s):  
Elizabeth T.C. Lippard ◽  
Carolyn M. Mazure ◽  
Jennifer A.Y. Johnston ◽  
Linda Spencer ◽  
Judah Weathers ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Substance Use ◽  
Sexual Dimorphism ◽  
Preliminary Evidence ◽  
Brain Circuitry

scholarly journals Mitochondrial Alterations in Fibroblasts of Early Stage Bipolar Disorder Patients

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 522
Author(s):  
Ana P. Marques ◽  
Rosa Resende ◽  
Diana F. Silva ◽  
Mariana Batista ◽  
Daniela Pereira ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Early Stage ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Respiratory Chain ◽  
Atp Depletion ◽  
Early Event ◽  
Mitochondrial Morphology ◽  
Mitochondrial Alterations ◽  
Transport Chain ◽  
Brain Circuitry

This study aims to evaluate whether mitochondrial changes occur in the early stages of bipolar disorder (BD). Using fibroblasts derived from BD patients and matched controls, the levels of proteins involved in mitochondrial biogenesis and dynamics (fission and fusion) were evaluated by Western Blot analysis. Mitochondrial membrane potential (MMP) was studied using the fluorescent probe TMRE. Mitochondrial morphology was analyzed with the probe Mitotracker Green and mitophagy was evaluated by quantifying the co-localization of HSP60 (mitochondria marker) and LC3B (autophagosome marker) by immunofluorescence. Furthermore, the activity of the mitochondrial respiratory chain and the glycolytic capacity of controls and BD patients-derived cells were also studied using the Seahorse technology. BD patient-derived fibroblasts exhibit fragmented mitochondria concomitantly with changes in mitochondrial dynamics and biogenesis in comparison with controls. Moreover, a decrease in the MMP and increased mitophagy was observed in fibroblasts obtained from BD patients when compared with control cells. Impaired energetic metabolism due to inhibition of the mitochondrial electron transport chain (ETC) and subsequent ATP depletion, associated with glycolysis stimulation, was also a feature of BD fibroblasts. Overall, these results support the fact that mitochondrial disturbance is an early event implicated in BD pathophysiology that might trigger neuronal changes and modification of brain circuitry.

Navigating Tx of Bipolar Disorder in Pregnancy

Ob Gyn News ◽  
2005 ◽  
Vol 40 (3) ◽  
pp. 11
Author(s):  
DIANA MAHONEY
Keyword(s):  
Bipolar Disorder ◽  
In Pregnancy

Valproate May Help Child With Bipolar Disorder

2005 ◽  
Vol 39 (5) ◽  
pp. 26
Author(s):  
Jeff Evans
Keyword(s):  
Bipolar Disorder

Diagnosis of Bipolar Disorder Usually Takes Several Years

2005 ◽  
Vol 38 (2) ◽  
pp. 19
Author(s):  
SHARON WORCESTER
Keyword(s):  
Bipolar Disorder

Bipolar Disorder

2017 ◽  
Author(s):  
Robert P. Reiser ◽  
Larry W. Thompson ◽  
Sheri L. Johnson ◽  
Trisha Suppes
Keyword(s):  
Bipolar Disorder

Childhood Bipolar Disorder: Documenting a Psychiatric/Cultural Orthodoxy

PsycCRITIQUES ◽  
2006 ◽  
Vol 51 (9) ◽  
Author(s):  
Tracy A. Knight
Keyword(s):  
Bipolar Disorder
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